Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study.
Identifieur interne : 002337 ( Ncbi/Curation ); précédent : 002336; suivant : 002338Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study.
Auteurs : Fang Tang [République populaire de Chine] ; Yan Quan ; Zhong-Tao Xin ; Jens Wrammert ; Mai-Juan Ma ; Hui Lv ; Tian-Bao Wang ; Hong Yang ; Jan H. Richardus ; Wei Liu ; Wu-Chun CaoSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antigènes viraux (analyse), Femelle, Flambées de maladies, Humains, Immunité cellulaire, Immunité humorale, Lymphocytes B (immunologie), Lymphocytes T (immunologie), Mâle, Mémoire immunologique (immunologie), Syndrome respiratoire aigu sévère (immunologie), Test ELISpot, Virus du SRAS (immunologie), Études cas-témoins, Études de suivi.
- MESH :
- analyse : Antigènes viraux.
- immunologie : Lymphocytes B, Lymphocytes T, Mémoire immunologique, Syndrome respiratoire aigu sévère, Virus du SRAS.
- Adulte, Adulte d'âge moyen, Femelle, Flambées de maladies, Humains, Immunité cellulaire, Immunité humorale, Mâle, Test ELISpot, Études cas-témoins, Études de suivi.
English descriptors
- KwdEn :
- Adult, Antigens, Viral (analysis), B-Lymphocytes (immunology), Case-Control Studies, Disease Outbreaks, Enzyme-Linked Immunospot Assay, Female, Follow-Up Studies, Humans, Immunity, Cellular, Immunity, Humoral, Immunologic Memory (immunology), Male, Middle Aged, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), T-Lymphocytes (immunology).
- MESH :
- chemical , analysis : Antigens, Viral.
- immunology : B-Lymphocytes, Immunologic Memory, SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes.
- Adult, Case-Control Studies, Disease Outbreaks, Enzyme-Linked Immunospot Assay, Female, Follow-Up Studies, Humans, Immunity, Cellular, Immunity, Humoral, Male, Middle Aged.
Abstract
Six years have passed since the outbreak of severe acute respiratory syndrome (SARS). Previous studies indicated that specific Abs to SARS-related coronavirus (SARS-CoV) waned over time in recovered SARS patients. It is critical to find out whether a potential anamnestic response, as seen with other viral infections, exists to protect a person from reinfection in case of another SARS outbreak. Recovered SARS patients were followed up to 6 y to estimate the longevity of specific Ab. The specific memory B cell and T cell responses to SARS-CoV Ags were measured by means of ELISPOT assay. Factors in relation to humoral and cellular immunity were investigated. Six years postinfection, specific IgG Ab to SARS-CoV became undetectable in 21 of the 23 former patients. No SARS-CoV Ag-specific memory B cell response was detected in either 23 former SARS patients or 22 close contacts of SARS patients. Memory T cell responses to a pool of SARS-CoV S peptides were identified in 14 of 23 (60.9%) recovered SARS patients, whereas there was no such specific response in either close contacts or healthy controls. Patients with more severe clinical manifestations seemed to present a higher level of Ag-specific memory T cell response. SARS-specific IgG Ab may eventually vanish and peripheral memory B cell responses are undetectable in recovered SARS patients. In contrast, specific T cell anamnestic responses can be maintained for at least 6 y. These findings have applications in preparation for the possible reemergence of SARS.
DOI: 10.4049/jimmunol.0903490
PubMed: 21576510
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Richardus</name></author><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name></author><author><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="eISSN">1550-6606</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Viral (analysis)</term><term>B-Lymphocytes (immunology)</term><term>Case-Control Studies</term><term>Disease Outbreaks</term><term>Enzyme-Linked Immunospot Assay</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Immunologic Memory (immunology)</term><term>Male</term><term>Middle Aged</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes viraux (analyse)</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes T (immunologie)</term><term>Mâle</term><term>Mémoire immunologique (immunologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Test ELISpot</term><term>Virus du SRAS (immunologie)</term><term>Études cas-témoins</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes B</term><term>Lymphocytes T</term><term>Mémoire immunologique</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>Immunologic Memory</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Disease Outbreaks</term><term>Enzyme-Linked Immunospot Assay</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Mâle</term><term>Test ELISpot</term><term>Études cas-témoins</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Six years have passed since the outbreak of severe acute respiratory syndrome (SARS). Previous studies indicated that specific Abs to SARS-related coronavirus (SARS-CoV) waned over time in recovered SARS patients. It is critical to find out whether a potential anamnestic response, as seen with other viral infections, exists to protect a person from reinfection in case of another SARS outbreak. Recovered SARS patients were followed up to 6 y to estimate the longevity of specific Ab. The specific memory B cell and T cell responses to SARS-CoV Ags were measured by means of ELISPOT assay. Factors in relation to humoral and cellular immunity were investigated. Six years postinfection, specific IgG Ab to SARS-CoV became undetectable in 21 of the 23 former patients. No SARS-CoV Ag-specific memory B cell response was detected in either 23 former SARS patients or 22 close contacts of SARS patients. Memory T cell responses to a pool of SARS-CoV S peptides were identified in 14 of 23 (60.9%) recovered SARS patients, whereas there was no such specific response in either close contacts or healthy controls. Patients with more severe clinical manifestations seemed to present a higher level of Ag-specific memory T cell response. SARS-specific IgG Ab may eventually vanish and peripheral memory B cell responses are undetectable in recovered SARS patients. In contrast, specific T cell anamnestic responses can be maintained for at least 6 y. These findings have applications in preparation for the possible reemergence of SARS.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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