Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study.
Identifieur interne : 002337 ( Ncbi/Merge ); précédent : 002336; suivant : 002338Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study.
Auteurs : Fang Tang [République populaire de Chine] ; Yan Quan ; Zhong-Tao Xin ; Jens Wrammert ; Mai-Juan Ma ; Hui Lv ; Tian-Bao Wang ; Hong Yang ; Jan H. Richardus ; Wei Liu ; Wu-Chun CaoSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antigènes viraux (analyse), Femelle, Flambées de maladies, Humains, Immunité cellulaire, Immunité humorale, Lymphocytes B (immunologie), Lymphocytes T (immunologie), Mâle, Mémoire immunologique (immunologie), Syndrome respiratoire aigu sévère (immunologie), Test ELISpot, Virus du SRAS (immunologie), Études cas-témoins, Études de suivi.
- MESH :
- analyse : Antigènes viraux.
- immunologie : Lymphocytes B, Lymphocytes T, Mémoire immunologique, Syndrome respiratoire aigu sévère, Virus du SRAS.
- Adulte, Adulte d'âge moyen, Femelle, Flambées de maladies, Humains, Immunité cellulaire, Immunité humorale, Mâle, Test ELISpot, Études cas-témoins, Études de suivi.
English descriptors
- KwdEn :
- Adult, Antigens, Viral (analysis), B-Lymphocytes (immunology), Case-Control Studies, Disease Outbreaks, Enzyme-Linked Immunospot Assay, Female, Follow-Up Studies, Humans, Immunity, Cellular, Immunity, Humoral, Immunologic Memory (immunology), Male, Middle Aged, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), T-Lymphocytes (immunology).
- MESH :
- chemical , analysis : Antigens, Viral.
- immunology : B-Lymphocytes, Immunologic Memory, SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes.
- Adult, Case-Control Studies, Disease Outbreaks, Enzyme-Linked Immunospot Assay, Female, Follow-Up Studies, Humans, Immunity, Cellular, Immunity, Humoral, Male, Middle Aged.
Abstract
Six years have passed since the outbreak of severe acute respiratory syndrome (SARS). Previous studies indicated that specific Abs to SARS-related coronavirus (SARS-CoV) waned over time in recovered SARS patients. It is critical to find out whether a potential anamnestic response, as seen with other viral infections, exists to protect a person from reinfection in case of another SARS outbreak. Recovered SARS patients were followed up to 6 y to estimate the longevity of specific Ab. The specific memory B cell and T cell responses to SARS-CoV Ags were measured by means of ELISPOT assay. Factors in relation to humoral and cellular immunity were investigated. Six years postinfection, specific IgG Ab to SARS-CoV became undetectable in 21 of the 23 former patients. No SARS-CoV Ag-specific memory B cell response was detected in either 23 former SARS patients or 22 close contacts of SARS patients. Memory T cell responses to a pool of SARS-CoV S peptides were identified in 14 of 23 (60.9%) recovered SARS patients, whereas there was no such specific response in either close contacts or healthy controls. Patients with more severe clinical manifestations seemed to present a higher level of Ag-specific memory T cell response. SARS-specific IgG Ab may eventually vanish and peripheral memory B cell responses are undetectable in recovered SARS patients. In contrast, specific T cell anamnestic responses can be maintained for at least 6 y. These findings have applications in preparation for the possible reemergence of SARS.
DOI: 10.4049/jimmunol.0903490
PubMed: 21576510
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Richardus</name></author><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name></author><author><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="eISSN">1550-6606</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Viral (analysis)</term><term>B-Lymphocytes (immunology)</term><term>Case-Control Studies</term><term>Disease Outbreaks</term><term>Enzyme-Linked Immunospot Assay</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Immunologic Memory (immunology)</term><term>Male</term><term>Middle Aged</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes viraux (analyse)</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes T (immunologie)</term><term>Mâle</term><term>Mémoire immunologique (immunologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Test ELISpot</term><term>Virus du SRAS (immunologie)</term><term>Études cas-témoins</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes B</term><term>Lymphocytes T</term><term>Mémoire immunologique</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>Immunologic Memory</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Disease Outbreaks</term><term>Enzyme-Linked Immunospot Assay</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Mâle</term><term>Test ELISpot</term><term>Études cas-témoins</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Six years have passed since the outbreak of severe acute respiratory syndrome (SARS). Previous studies indicated that specific Abs to SARS-related coronavirus (SARS-CoV) waned over time in recovered SARS patients. It is critical to find out whether a potential anamnestic response, as seen with other viral infections, exists to protect a person from reinfection in case of another SARS outbreak. Recovered SARS patients were followed up to 6 y to estimate the longevity of specific Ab. The specific memory B cell and T cell responses to SARS-CoV Ags were measured by means of ELISPOT assay. Factors in relation to humoral and cellular immunity were investigated. Six years postinfection, specific IgG Ab to SARS-CoV became undetectable in 21 of the 23 former patients. No SARS-CoV Ag-specific memory B cell response was detected in either 23 former SARS patients or 22 close contacts of SARS patients. Memory T cell responses to a pool of SARS-CoV S peptides were identified in 14 of 23 (60.9%) recovered SARS patients, whereas there was no such specific response in either close contacts or healthy controls. Patients with more severe clinical manifestations seemed to present a higher level of Ag-specific memory T cell response. SARS-specific IgG Ab may eventually vanish and peripheral memory B cell responses are undetectable in recovered SARS patients. In contrast, specific T cell anamnestic responses can be maintained for at least 6 y. These findings have applications in preparation for the possible reemergence of SARS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21576510</PMID><DateCompleted><Year>2011</Year><Month>10</Month><Day>07</Day></DateCompleted><DateRevised><Year>2011</Year><Month>06</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1550-6606</ISSN><JournalIssue CitedMedium="Internet"><Volume>186</Volume><Issue>12</Issue><PubDate><Year>2011</Year><Month>Jun</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of immunology (Baltimore, Md. : 1950)</Title><ISOAbbreviation>J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study.</ArticleTitle><Pagination><MedlinePgn>7264-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4049/jimmunol.0903490</ELocationID><Abstract><AbstractText>Six years have passed since the outbreak of severe acute respiratory syndrome (SARS). Previous studies indicated that specific Abs to SARS-related coronavirus (SARS-CoV) waned over time in recovered SARS patients. It is critical to find out whether a potential anamnestic response, as seen with other viral infections, exists to protect a person from reinfection in case of another SARS outbreak. Recovered SARS patients were followed up to 6 y to estimate the longevity of specific Ab. The specific memory B cell and T cell responses to SARS-CoV Ags were measured by means of ELISPOT assay. Factors in relation to humoral and cellular immunity were investigated. Six years postinfection, specific IgG Ab to SARS-CoV became undetectable in 21 of the 23 former patients. No SARS-CoV Ag-specific memory B cell response was detected in either 23 former SARS patients or 22 close contacts of SARS patients. Memory T cell responses to a pool of SARS-CoV S peptides were identified in 14 of 23 (60.9%) recovered SARS patients, whereas there was no such specific response in either close contacts or healthy controls. Patients with more severe clinical manifestations seemed to present a higher level of Ag-specific memory T cell response. SARS-specific IgG Ab may eventually vanish and peripheral memory B cell responses are undetectable in recovered SARS patients. In contrast, specific T cell anamnestic responses can be maintained for at least 6 y. These findings have applications in preparation for the possible reemergence of SARS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Fang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quan</LastName><ForeName>Yan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Xin</LastName><ForeName>Zhong-Tao</ForeName><Initials>ZT</Initials></Author><Author ValidYN="Y"><LastName>Wrammert</LastName><ForeName>Jens</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Mai-Juan</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Lv</LastName><ForeName>Hui</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Tian-Bao</ForeName><Initials>TB</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Hong</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Richardus</LastName><ForeName>Jan H</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Wu-Chun</ForeName><Initials>WC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>05</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Immunol</MedlineTA><NlmUniqueID>2985117R</NlmUniqueID><ISSNLinking>0022-1767</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001402" MajorTopicYN="N">B-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058501" MajorTopicYN="N">Enzyme-Linked Immunospot Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007111" MajorTopicYN="N">Immunity, Cellular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056724" MajorTopicYN="N">Immunity, Humoral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007156" MajorTopicYN="N">Immunologic Memory</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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last="Quan">Yan Quan</name><name sortKey="Richardus, Jan H" sort="Richardus, Jan H" uniqKey="Richardus J" first="Jan H" last="Richardus">Jan H. Richardus</name><name sortKey="Wang, Tian Bao" sort="Wang, Tian Bao" uniqKey="Wang T" first="Tian-Bao" last="Wang">Tian-Bao Wang</name><name sortKey="Wrammert, Jens" sort="Wrammert, Jens" uniqKey="Wrammert J" first="Jens" last="Wrammert">Jens Wrammert</name><name sortKey="Xin, Zhong Tao" sort="Xin, Zhong Tao" uniqKey="Xin Z" first="Zhong-Tao" last="Xin">Zhong-Tao Xin</name><name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Tang, Fang" sort="Tang, Fang" uniqKey="Tang F" first="Fang" last="Tang">Fang Tang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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