Antivirals and antiviral strategies
Identifieur interne : 000A76 ( Ncbi/Curation ); précédent : 000A75; suivant : 000A77Antivirals and antiviral strategies
Auteurs : Erik De ClercqSource :
- Nature Reviews. Microbiology [ 1740-1526 ] ; 2004.
Descripteurs français
- KwdFr :
- Adenosylhomocysteinase (antagonistes et inhibiteurs), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Helicase (antagonistes et inhibiteurs), Humains, IMP dehydrogenase (antagonistes et inhibiteurs), Inhibiteurs de la synthèse d'acide nucléique, Interférons (usage thérapeutique), Maladies virales (), Maladies virales (traitement médicamenteux), Nucleoside-triphosphatase (antagonistes et inhibiteurs), Protéines virales (antagonistes et inhibiteurs), RNA replicase (antagonistes et inhibiteurs), Virus ().
- MESH :
- antagonistes et inhibiteurs : Adenosylhomocysteinase, Helicase, IMP dehydrogenase, Nucleoside-triphosphatase, Protéines virales, RNA replicase.
- pharmacologie : Antiviraux.
- traitement médicamenteux : Maladies virales.
- usage thérapeutique : Antiviraux, Interférons.
- Humains, Inhibiteurs de la synthèse d'acide nucléique, Maladies virales, Virus.
English descriptors
- KwdEn :
- Adenosylhomocysteinase (antagonists & inhibitors), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), DNA Helicases (antagonists & inhibitors), Humans, IMP Dehydrogenase (antagonists & inhibitors), Interferons (therapeutic use), Nucleic Acid Synthesis Inhibitors, Nucleoside-Triphosphatase (antagonists & inhibitors), RNA Replicase (antagonists & inhibitors), Viral Proteins (antagonists & inhibitors), Virus Diseases (drug therapy), Virus Diseases (prevention & control), Viruses (drug effects).
- MESH :
- chemical , antagonists & inhibitors : Adenosylhomocysteinase, DNA Helicases, IMP Dehydrogenase, Nucleoside-Triphosphatase, RNA Replicase, Viral Proteins.
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents, Interferons.
- drug effects : Viruses.
- drug therapy : Virus Diseases.
- prevention & control : Virus Diseases.
- Humans, Nucleic Acid Synthesis Inhibitors.
Abstract
In this article, the usefulness, or potential usefulness, of the currently licensed antiviral drugs and those in clinical or preclinical development is evaluated. The main conclusions are: For the treatment of polyomavirus, papillomavirus, adenovirus and poxvirus infections, the acyclic nucleoside phosphonates such as cidofovir have the greatest potential. For the treatment of HSV and VZV infections, (val)acyclovir, famciclovir and brivudin are important. For the treatment of CMV infections, (val)ganciclovir, cidofovir and foscarnet are the most promising. Ribavirin is proposed for the treatment of (−)RNA virus (such as arenavirus and bunyavirus) infections, whereas IFN and IFN inducers are envisaged for the treatment of (+)RNA virus infections, particularly picornavirus (for example, coxsackie B) and togavirus (for example, Western, Eastern and Venezuelan equine encephalitis virus) infections. For the treatment of HCV infections, pegylated IFN, in combination with ribavirin, is currently recommended, although compounds targeted at the HCV protease and RNA-dependent RNA polymerase have also been developed. For the therapy and prophylaxis of influenza virus infections, the neuraminidase inhibitors zanamivir and oseltamivir are the current drugs of choice. Among the paramyxoviruses, human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the viruses for which antiviral therapy is most required. Although ribavirin is available for the treatment of RSV infections, it is not ideal, and therefore, new compounds are required for the treatment of hMPV and RSV infections. A plethora of 'old' and 'new' compounds are available or are being developed for the treatment of HIV infections. Multiple drug regimens might be beneficial for HIV treatment. For other virus infections —rotavirus, and Ebola, Marburg and other haemorrhagic virus infections — the choice of potential antiviral agents is rather limited, however, SAH hydrolase inhibitors such as 3-deazaneplanocin A are currently the most promising.
The online version of this article (doi:10.1038/nrmicro975) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nrmicro975
PubMed: 15372081
PubMed Central: 7097272
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000563
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000563
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001728
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002B51
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002B51
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002E20
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000A76
Links to Exploration step
PMC:7097272Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antivirals and antiviral strategies</title><author><name sortKey="Clercq, Erik De" sort="Clercq, Erik De" uniqKey="Clercq E" first="Erik De" last="Clercq">Erik De Clercq</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15372081</idno><idno type="pmc">7097272</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097272</idno><idno type="RBID">PMC:7097272</idno><idno type="doi">10.1038/nrmicro975</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000563</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000563</idno><idno type="wicri:Area/Pmc/Curation">000563</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000563</idno><idno type="wicri:Area/Pmc/Checkpoint">001728</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001728</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:15372081</idno><idno type="wicri:Area/PubMed/Corpus">002B51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B51</idno><idno type="wicri:Area/PubMed/Curation">002B51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B51</idno><idno type="wicri:Area/PubMed/Checkpoint">002E20</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002E20</idno><idno type="wicri:Area/Ncbi/Merge">000A76</idno><idno type="wicri:Area/Ncbi/Curation">000A76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antivirals and antiviral strategies</title><author><name sortKey="Clercq, Erik De" sort="Clercq, Erik De" uniqKey="Clercq E" first="Erik De" last="Clercq">Erik De Clercq</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Nature Reviews. Microbiology</title><idno type="ISSN">1740-1526</idno><idno type="eISSN">1740-1534</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosylhomocysteinase (antagonists & inhibitors)</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>DNA Helicases (antagonists & inhibitors)</term><term>Humans</term><term>IMP Dehydrogenase (antagonists & inhibitors)</term><term>Interferons (therapeutic use)</term><term>Nucleic Acid Synthesis Inhibitors</term><term>Nucleoside-Triphosphatase (antagonists & inhibitors)</term><term>RNA Replicase (antagonists & inhibitors)</term><term>Viral Proteins (antagonists & inhibitors)</term><term>Virus Diseases (drug therapy)</term><term>Virus Diseases (prevention & control)</term><term>Viruses (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenosylhomocysteinase (antagonistes et inhibiteurs)</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Helicase (antagonistes et inhibiteurs)</term><term>Humains</term><term>IMP dehydrogenase (antagonistes et inhibiteurs)</term><term>Inhibiteurs de la synthèse d'acide nucléique</term><term>Interférons (usage thérapeutique)</term><term>Maladies virales ()</term><term>Maladies virales (traitement médicamenteux)</term><term>Nucleoside-triphosphatase (antagonistes et inhibiteurs)</term><term>Protéines virales (antagonistes et inhibiteurs)</term><term>RNA replicase (antagonistes et inhibiteurs)</term><term>Virus ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Adenosylhomocysteinase</term><term>DNA Helicases</term><term>IMP Dehydrogenase</term><term>Nucleoside-Triphosphatase</term><term>RNA Replicase</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Interferons</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Adenosylhomocysteinase</term><term>Helicase</term><term>IMP dehydrogenase</term><term>Nucleoside-triphosphatase</term><term>Protéines virales</term><term>RNA replicase</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Interférons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Nucleic Acid Synthesis Inhibitors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Inhibiteurs de la synthèse d'acide nucléique</term><term>Maladies virales</term><term>Virus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p id="Par2"><list list-type="bullet"><list-item><p id="Par3">In this article, the usefulness, or potential usefulness, of the currently licensed antiviral drugs and those in clinical or preclinical development is evaluated. The main conclusions are:</p></list-item><list-item><p id="Par4">For the treatment of polyomavirus, papillomavirus, adenovirus and poxvirus infections, the acyclic nucleoside phosphonates such as cidofovir have the greatest potential.</p></list-item><list-item><p id="Par5">For the treatment of HSV and VZV infections, (val)acyclovir, famciclovir and brivudin are important.</p></list-item><list-item><p id="Par6">For the treatment of CMV infections, (val)ganciclovir, cidofovir and foscarnet are the most promising.</p></list-item><list-item><p id="Par7">Ribavirin is proposed for the treatment of (−)RNA virus (such as arenavirus and bunyavirus) infections, whereas IFN and IFN inducers are envisaged for the treatment of (+)RNA virus infections, particularly picornavirus (for example, coxsackie B) and togavirus (for example, Western, Eastern and Venezuelan equine encephalitis virus) infections.</p></list-item><list-item><p id="Par8">For the treatment of HCV infections, pegylated IFN, in combination with ribavirin, is currently recommended, although compounds targeted at the HCV protease and RNA-dependent RNA polymerase have also been developed.</p></list-item><list-item><p id="Par9">For the therapy and prophylaxis of influenza virus infections, the neuraminidase inhibitors zanamivir and oseltamivir are the current drugs of choice.</p></list-item><list-item><p id="Par10">Among the paramyxoviruses, human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the viruses for which antiviral therapy is most required. Although ribavirin is available for the treatment of RSV infections, it is not ideal, and therefore, new compounds are required for the treatment of hMPV and RSV infections.</p></list-item><list-item><p id="Par11">A plethora of 'old' and 'new' compounds are available or are being developed for the treatment of HIV infections. Multiple drug regimens might be beneficial for HIV treatment.</p></list-item><list-item><p id="Par12">For other virus infections —rotavirus, and Ebola, Marburg and other haemorrhagic virus infections — the choice of potential antiviral agents is rather limited, however, SAH hydrolase inhibitors such as 3-deazaneplanocin A are currently the most promising.</p></list-item></list></p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nrmicro975) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrei, G" uniqKey="Andrei G">G Andrei</name></author><author><name sortKey="Snoeck, R" uniqKey="Snoeck R">R Snoeck</name></author><author><name sortKey="Vandeputte, M" uniqKey="Vandeputte M">M Vandeputte</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrei, G" uniqKey="Andrei G">G Andrei</name></author><author><name sortKey="Snoeck, R" uniqKey="Snoeck R">R Snoeck</name></author><author><name sortKey="Schols, D" uniqKey="Schols D">D Schols</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdulkarin, B" uniqKey="Abdulkarin B">B Abdulkarin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrei, G" uniqKey="Andrei G">G Andrei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bordigoni, P" uniqKey="Bordigoni P">P Bordigoni</name></author><author><name sortKey="Carret, A" uniqKey="Carret A">A–S Carret</name></author><author><name sortKey="Venard, V" uniqKey="Venard V">V Venard</name></author><author><name sortKey="Witz, F" uniqKey="Witz F">F Witz</name></author><author><name sortKey="Le Faou, A" uniqKey="Le Faou A">A Le Faou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, S" uniqKey="Zhou S">S Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcguigan, C" uniqKey="Mcguigan C">C McGuigan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcguigan, C" uniqKey="Mcguigan C">C McGuigan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crumpacker, Cs" uniqKey="Crumpacker C">CS Crumpacker</name></author><author><name sortKey="Schaffer, Pa" uniqKey="Schaffer P">PA Schaffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crute, Jj" uniqKey="Crute J">JJ Crute</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kleymann, G" uniqKey="Kleymann G">G Kleymann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Betz, Uak" uniqKey="Betz U">UAK Betz</name></author><author><name sortKey="Fischer, R" uniqKey="Fischer R">R Fischer</name></author><author><name sortKey="Kleymann, G" uniqKey="Kleymann G">G Kleymann</name></author><author><name sortKey="Hendrix, M" uniqKey="Hendrix M">M Hendrix</name></author><author><name sortKey="Rubsamen Waigmann, H" uniqKey="Rubsamen Waigmann H">H Rübsamen-Waigmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snoeck, R" uniqKey="Snoeck R">R Snoeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oien, Nl" uniqKey="Oien N">NL Oien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomsen, Dr" uniqKey="Thomsen D">DR Thomsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buerger, I" uniqKey="Buerger I">I Buerger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krosky, Pm" uniqKey="Krosky P">PM Krosky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biron, Kk" uniqKey="Biron K">KK Biron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krosky, Pm" uniqKey="Krosky P">PM Krosky</name></author><author><name sortKey="Beak, M C" uniqKey="Beak M">M-C Beak</name></author><author><name sortKey="Coen, Dm" uniqKey="Coen D">DM Coen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koszalka, Gw" uniqKey="Koszalka G">GW Koszalka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lalezari, Jp" uniqKey="Lalezari J">JP Lalezari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Sl" uniqKey="Williams S">SL Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahy, Bwj" uniqKey="Mahy B">BWJ Mahy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bauer, Dj" uniqKey="Bauer D">DJ Bauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Safrin, S" uniqKey="Safrin S">S Safrin</name></author><author><name sortKey="Cherrington, J" uniqKey="Cherrington J">J Cherrington</name></author><author><name sortKey="Jaffe, Hs" uniqKey="Jaffe H">HS Jaffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, Ro" uniqKey="Baker R">RO Baker</name></author><author><name sortKey="Bray, M" uniqKey="Bray M">M Bray</name></author><author><name sortKey="Huggins, Jw" uniqKey="Huggins J">JW Huggins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author><author><name sortKey="Sidwell, Rw" uniqKey="Sidwell R">RW Sidwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neyts, J" uniqKey="Neyts J">J Neyts</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author><author><name sortKey="Neyts, J" uniqKey="Neyts J">J Neyts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kern, Er" uniqKey="Kern E">ER Kern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aldern, Ka" uniqKey="Aldern K">KA Aldern</name></author><author><name sortKey="Ciesla, Sl" uniqKey="Ciesla S">SL Ciesla</name></author><author><name sortKey="Winegarden, Kl" uniqKey="Winegarden K">KL Winegarden</name></author><author><name sortKey="Hostetler, Ky" uniqKey="Hostetler K">KY Hostetler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neyts, J" uniqKey="Neyts J">J Neyts</name></author><author><name sortKey="Leyssen, P" uniqKey="Leyssen P">P Leyssen</name></author><author><name sortKey="Verbeken, E" uniqKey="Verbeken E">E Verbeken</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marcellin, P" uniqKey="Marcellin P">P Marcellin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hadziyannis, Sj" uniqKey="Hadziyannis S">SJ Hadziyannis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buti, M" uniqKey="Buti M">M Buti</name></author><author><name sortKey="Esteban, R" uniqKey="Esteban R">R Esteban</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, C L" uniqKey="Lai C">C-L Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marion, Pl" uniqKey="Marion P">PL Marion</name></author><author><name sortKey="Salazar, Fh" uniqKey="Salazar F">FH Salazar</name></author><author><name sortKey="Winters, Ma" uniqKey="Winters M">MA Winters</name></author><author><name sortKey="Colonno, Rj" uniqKey="Colonno R">RJ Colonno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levine, S" uniqKey="Levine S">S Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peek, Sf" uniqKey="Peek S">SF Peek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menne, S" uniqKey="Menne S">S Menne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernandez Santiago, B" uniqKey="Hernandez Santiago B">B Hernandez-Santiago</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krishnan, P" uniqKey="Krishnan P">P Krishnan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Y" uniqKey="Shen Y">Y Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ledford, Rm" uniqKey="Ledford R">RM Ledford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romero, Jr" uniqKey="Romero J">JR Romero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schiff, Gm" uniqKey="Schiff G">GM Schiff</name></author><author><name sortKey="Sherwood, Jr" uniqKey="Sherwood J">JR Sherwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rotbart, Ha" uniqKey="Rotbart H">HA Rotbart</name></author><author><name sortKey="Webster, Ad" uniqKey="Webster A">AD Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padalko, E" uniqKey="Padalko E">E Padalko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padalko, E" uniqKey="Padalko E">E Padalko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gritsun, Ts" uniqKey="Gritsun T">TS Gritsun</name></author><author><name sortKey="Lashkevich, Va" uniqKey="Lashkevich V">VA Lashkevich</name></author><author><name sortKey="Gould, Ea" uniqKey="Gould E">EA Gould</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leyssen, P" uniqKey="Leyssen P">P Leyssen</name></author><author><name sortKey="Charlier, N" uniqKey="Charlier N">N Charlier</name></author><author><name sortKey="Paeshuyse" uniqKey="Paeshuyse">Paeshuyse</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author><author><name sortKey="Neyts, J" uniqKey="Neyts J">J Neyts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrey, Jd" uniqKey="Morrey J">JD Morrey</name></author><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author><author><name sortKey="Sidwell, Rw" uniqKey="Sidwell R">RW Sidwell</name></author><author><name sortKey="Tseng, C" uniqKey="Tseng C">C Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leyssen, P" uniqKey="Leyssen P">P Leyssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leyssen, P" uniqKey="Leyssen P">P Leyssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charrel, Rn" uniqKey="Charrel R">RN Charrel</name></author><author><name sortKey="De Lamballerie, X" uniqKey="De Lamballerie X">X de Lamballerie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrei, G" uniqKey="Andrei G">G Andrei</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccormick, Jb" uniqKey="Mccormick J">JB McCormick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidwell, Rw" uniqKey="Sidwell R">RW Sidwell</name></author><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clement, Jp" uniqKey="Clement J">JP Clement</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bray, M" uniqKey="Bray M">M Bray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jahrling, Pb" uniqKey="Jahrling P">PB Jahrling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bray, M" uniqKey="Bray M">M Bray</name></author><author><name sortKey="Driscoll, J" uniqKey="Driscoll J">J Driscoll</name></author><author><name sortKey="Huggins, Jw" uniqKey="Huggins J">JW Huggins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bray, M" uniqKey="Bray M">M Bray</name></author><author><name sortKey="Raymond, Jl" uniqKey="Raymond J">JL Raymond</name></author><author><name sortKey="Geisbert, T" uniqKey="Geisbert T">T Geisbert</name></author><author><name sortKey="Baker, Ro" uniqKey="Baker R">RO Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carter, Wa" uniqKey="Carter W">WA Carter</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, S" uniqKey="Tan S">S–L Tan</name></author><author><name sortKey="Pause, A" uniqKey="Pause A">A Pause</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Sonenberg, N" uniqKey="Sonenberg N">N Sonenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hadziyannis, Sj" uniqKey="Hadziyannis S">SJ Hadziyannis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drusano, Gl" uniqKey="Drusano G">GL Drusano</name></author><author><name sortKey="Preston, Sl" uniqKey="Preston S">SL Preston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borowski, P" uniqKey="Borowski P">P Borowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamarre, D" uniqKey="Lamarre D">D Lamarre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baginski, Sg" uniqKey="Baginski S">SG Baginski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, J" uniqKey="Sun J">J–H Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paeshuyse, J" uniqKey="Paeshuyse J">J Paeshuyse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stuyver, Lj" uniqKey="Stuyver L">LJ Stuyver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koopmans, M" uniqKey="Koopmans M">M Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Cu" uniqKey="Kim C">CU Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lam, S" uniqKey="Lam S">S–K Lam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Hoogen, Bg" uniqKey="Van Den Hoogen B">BG van den Hoogen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Hoogen, Bg" uniqKey="Van Den Hoogen B">BG van den Hoogen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zambon, Mc" uniqKey="Zambon M">MC Zambon</name></author><author><name sortKey="Stockton, Jd" uniqKey="Stockton J">JD Stockton</name></author><author><name sortKey="Clewley, Jp" uniqKey="Clewley J">JP Clewley</name></author><author><name sortKey="Fleming, Dm" uniqKey="Fleming D">DM Fleming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huntley, Cc" uniqKey="Huntley C">CC Huntley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stadler, K" uniqKey="Stadler K">K Stadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Towler, P" uniqKey="Towler P">P Towler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P Wadhwani</name></author><author><name sortKey="Mesters, Jr" uniqKey="Mesters J">JR Mesters</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, K C" uniqKey="Chou K">K-C Chou</name></author><author><name sortKey="Wei, Dq" uniqKey="Wei D">DQ Wei</name></author><author><name sortKey="Zhong, W Z" uniqKey="Zhong W">W-Z Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanner, Ja" uniqKey="Tanner J">JA Tanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnard, Dl" uniqKey="Barnard D">DL Barnard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balzarini, J" uniqKey="Balzarini J">J Balzarini</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Vijgen, L" uniqKey="Vijgen L">L Vijgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000A76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:7097272
|texte= Antivirals and antiviral strategies
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:15372081" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |