Antivirals and antiviral strategies
Identifieur interne : 001728 ( Pmc/Checkpoint ); précédent : 001727; suivant : 001729Antivirals and antiviral strategies
Auteurs : Erik De ClercqSource :
- Nature Reviews. Microbiology [ 1740-1526 ] ; 2004.
Abstract
In this article, the usefulness, or potential usefulness, of the currently licensed antiviral drugs and those in clinical or preclinical development is evaluated. The main conclusions are: For the treatment of polyomavirus, papillomavirus, adenovirus and poxvirus infections, the acyclic nucleoside phosphonates such as cidofovir have the greatest potential. For the treatment of HSV and VZV infections, (val)acyclovir, famciclovir and brivudin are important. For the treatment of CMV infections, (val)ganciclovir, cidofovir and foscarnet are the most promising. Ribavirin is proposed for the treatment of (−)RNA virus (such as arenavirus and bunyavirus) infections, whereas IFN and IFN inducers are envisaged for the treatment of (+)RNA virus infections, particularly picornavirus (for example, coxsackie B) and togavirus (for example, Western, Eastern and Venezuelan equine encephalitis virus) infections. For the treatment of HCV infections, pegylated IFN, in combination with ribavirin, is currently recommended, although compounds targeted at the HCV protease and RNA-dependent RNA polymerase have also been developed. For the therapy and prophylaxis of influenza virus infections, the neuraminidase inhibitors zanamivir and oseltamivir are the current drugs of choice. Among the paramyxoviruses, human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the viruses for which antiviral therapy is most required. Although ribavirin is available for the treatment of RSV infections, it is not ideal, and therefore, new compounds are required for the treatment of hMPV and RSV infections. A plethora of 'old' and 'new' compounds are available or are being developed for the treatment of HIV infections. Multiple drug regimens might be beneficial for HIV treatment. For other virus infections —rotavirus, and Ebola, Marburg and other haemorrhagic virus infections — the choice of potential antiviral agents is rather limited, however, SAH hydrolase inhibitors such as 3-deazaneplanocin A are currently the most promising.
The online version of this article (doi:10.1038/nrmicro975) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nrmicro975
PubMed: 15372081
PubMed Central: 7097272
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antivirals and antiviral strategies</title><author><name sortKey="Clercq, Erik De" sort="Clercq, Erik De" uniqKey="Clercq E" first="Erik De" last="Clercq">Erik De Clercq</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15372081</idno><idno type="pmc">7097272</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097272</idno><idno type="RBID">PMC:7097272</idno><idno type="doi">10.1038/nrmicro975</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000563</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000563</idno><idno type="wicri:Area/Pmc/Curation">000563</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000563</idno><idno type="wicri:Area/Pmc/Checkpoint">001728</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001728</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antivirals and antiviral strategies</title><author><name sortKey="Clercq, Erik De" sort="Clercq, Erik De" uniqKey="Clercq E" first="Erik De" last="Clercq">Erik De Clercq</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Nature Reviews. Microbiology</title><idno type="ISSN">1740-1526</idno><idno type="eISSN">1740-1534</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p id="Par2"><list list-type="bullet"><list-item><p id="Par3">In this article, the usefulness, or potential usefulness, of the currently licensed antiviral drugs and those in clinical or preclinical development is evaluated. The main conclusions are:</p></list-item><list-item><p id="Par4">For the treatment of polyomavirus, papillomavirus, adenovirus and poxvirus infections, the acyclic nucleoside phosphonates such as cidofovir have the greatest potential.</p></list-item><list-item><p id="Par5">For the treatment of HSV and VZV infections, (val)acyclovir, famciclovir and brivudin are important.</p></list-item><list-item><p id="Par6">For the treatment of CMV infections, (val)ganciclovir, cidofovir and foscarnet are the most promising.</p></list-item><list-item><p id="Par7">Ribavirin is proposed for the treatment of (−)RNA virus (such as arenavirus and bunyavirus) infections, whereas IFN and IFN inducers are envisaged for the treatment of (+)RNA virus infections, particularly picornavirus (for example, coxsackie B) and togavirus (for example, Western, Eastern and Venezuelan equine encephalitis virus) infections.</p></list-item><list-item><p id="Par8">For the treatment of HCV infections, pegylated IFN, in combination with ribavirin, is currently recommended, although compounds targeted at the HCV protease and RNA-dependent RNA polymerase have also been developed.</p></list-item><list-item><p id="Par9">For the therapy and prophylaxis of influenza virus infections, the neuraminidase inhibitors zanamivir and oseltamivir are the current drugs of choice.</p></list-item><list-item><p id="Par10">Among the paramyxoviruses, human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the viruses for which antiviral therapy is most required. Although ribavirin is available for the treatment of RSV infections, it is not ideal, and therefore, new compounds are required for the treatment of hMPV and RSV infections.</p></list-item><list-item><p id="Par11">A plethora of 'old' and 'new' compounds are available or are being developed for the treatment of HIV infections. Multiple drug regimens might be beneficial for HIV treatment.</p></list-item><list-item><p id="Par12">For other virus infections —rotavirus, and Ebola, Marburg and other haemorrhagic virus infections — the choice of potential antiviral agents is rather limited, however, SAH hydrolase inhibitors such as 3-deazaneplanocin A are currently the most promising.</p></list-item></list></p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nrmicro975) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrei, G" uniqKey="Andrei G">G 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Nat Rev Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Rev. Microbiol</journal-id><journal-title-group><journal-title>Nature Reviews. Microbiology</journal-title></journal-title-group><issn pub-type="ppub">1740-1526</issn><issn pub-type="epub">1740-1534</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15372081</article-id><article-id pub-id-type="pmc">7097272</article-id><article-id pub-id-type="publisher-id">BFnrmicro975</article-id><article-id pub-id-type="doi">10.1038/nrmicro975</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Antivirals and antiviral strategies</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Clercq</surname><given-names>Erik De</given-names></name><address><email>erik.declercq@rega.kuleuven.ac.be</email></address><xref ref-type="aff" rid="Aff1"></xref><bio><p id="Par1">Erik De Clercq holds the Professor P. De Somer Chair of Microbiology at the School of Medicine, Katholieke Universiteit Leuven, Belgium, where he teaches courses in cell biology, biochemistry, virology and microbiology to undergraduate medical students. He obtained his M.D. in 1966 from Leuven University Medical School and, after research fellowships at Stanford, he returned to Leuven University to obtain his Ph.D. He is now Chairman of the Department of Microbiology and Immunology at Leuven University, and Chairman of the Directory Board of the Rega Institute. His research covers many aspects of antiviral chemotherapy. He was one of the founders of the International Society for Antiviral Research in 1988.</p></bio></contrib><aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.5596.f</institution-id><institution-id institution-id-type="ISNI">0000 0001 0668 7884</institution-id><institution>Rega Institute for Medical Research, Katholieke Universiteit Leuven,</institution></institution-wrap>Leuven, B-3000 Belgium</aff></contrib-group><pub-date pub-type="ppub"><year>2004</year></pub-date><volume>2</volume><issue>9</issue><fpage>704</fpage><lpage>720</lpage><permissions><copyright-statement>© Nature Publishing Group 2004</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1" abstract-type="KeyPoints"><title>Key Points</title><p id="Par2"><list list-type="bullet"><list-item><p id="Par3">In this article, the usefulness, or potential usefulness, of the currently licensed antiviral drugs and those in clinical or preclinical development is evaluated. The main conclusions are:</p></list-item><list-item><p id="Par4">For the treatment of polyomavirus, papillomavirus, adenovirus and poxvirus infections, the acyclic nucleoside phosphonates such as cidofovir have the greatest potential.</p></list-item><list-item><p id="Par5">For the treatment of HSV and VZV infections, (val)acyclovir, famciclovir and brivudin are important.</p></list-item><list-item><p id="Par6">For the treatment of CMV infections, (val)ganciclovir, cidofovir and foscarnet are the most promising.</p></list-item><list-item><p id="Par7">Ribavirin is proposed for the treatment of (−)RNA virus (such as arenavirus and bunyavirus) infections, whereas IFN and IFN inducers are envisaged for the treatment of (+)RNA virus infections, particularly picornavirus (for example, coxsackie B) and togavirus (for example, Western, Eastern and Venezuelan equine encephalitis virus) infections.</p></list-item><list-item><p id="Par8">For the treatment of HCV infections, pegylated IFN, in combination with ribavirin, is currently recommended, although compounds targeted at the HCV protease and RNA-dependent RNA polymerase have also been developed.</p></list-item><list-item><p id="Par9">For the therapy and prophylaxis of influenza virus infections, the neuraminidase inhibitors zanamivir and oseltamivir are the current drugs of choice.</p></list-item><list-item><p id="Par10">Among the paramyxoviruses, human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the viruses for which antiviral therapy is most required. Although ribavirin is available for the treatment of RSV infections, it is not ideal, and therefore, new compounds are required for the treatment of hMPV and RSV infections.</p></list-item><list-item><p id="Par11">A plethora of 'old' and 'new' compounds are available or are being developed for the treatment of HIV infections. Multiple drug regimens might be beneficial for HIV treatment.</p></list-item><list-item><p id="Par12">For other virus infections —rotavirus, and Ebola, Marburg and other haemorrhagic virus infections — the choice of potential antiviral agents is rather limited, however, SAH hydrolase inhibitors such as 3-deazaneplanocin A are currently the most promising.</p></list-item></list></p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nrmicro975) contains supplementary material, which is available to authorized users.</p></sec></abstract><abstract id="Abs2"><p id="Par13">In recent years, the demand for new antiviral strategies has increased markedly. There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral infections such as HIV and hepatitis B and C, and the emergence of new viruses such as the SARS coronavirus. The potential danger of haemorrhagic fever viruses and eradicated viruses such as variola virus being used as bioterrorist weapons has also increased the profile of antiviral drug discovery. Here, the virus infections for which antiviral therapy is needed and the compounds that are available, or are being developed, for the treatment of these infections are described.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nrmicro975) contains supplementary material, which is available to authorized users.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Nature Limited 2004</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Clercq, Erik De" sort="Clercq, Erik De" uniqKey="Clercq E" first="Erik De" last="Clercq">Erik De Clercq</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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