Antivirals and antiviral strategies.
Identifieur interne : 002B51 ( PubMed/Corpus ); précédent : 002B50; suivant : 002B52Antivirals and antiviral strategies.
Auteurs : Erik De ClercqSource :
- Nature reviews. Microbiology [ 1740-1526 ] ; 2004.
English descriptors
- KwdEn :
- Adenosylhomocysteinase (antagonists & inhibitors), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), DNA Helicases (antagonists & inhibitors), Humans, IMP Dehydrogenase (antagonists & inhibitors), Interferons (therapeutic use), Nucleic Acid Synthesis Inhibitors, Nucleoside-Triphosphatase (antagonists & inhibitors), RNA Replicase (antagonists & inhibitors), Viral Proteins (antagonists & inhibitors), Virus Diseases (drug therapy), Virus Diseases (prevention & control), Viruses (drug effects).
- MESH :
- chemical , antagonists & inhibitors : Adenosylhomocysteinase, DNA Helicases, IMP Dehydrogenase, Nucleoside-Triphosphatase, RNA Replicase, Viral Proteins.
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents, Interferons.
- drug effects : Viruses.
- drug therapy : Virus Diseases.
- prevention & control : Virus Diseases.
- Humans, Nucleic Acid Synthesis Inhibitors.
Abstract
In recent years, the demand for new antiviral strategies has increased markedly. There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral infections such as HIV and hepatitis B and C, and the emergence of new viruses such as the SARS coronavirus. The potential danger of haemorrhagic fever viruses and eradicated viruses such as variola virus being used as bioterrorist weapons has also increased the profile of antiviral drug discovery. Here, the virus infections for which antiviral therapy is needed and the compounds that are available, or are being developed, for the treatment of these infections are described.
DOI: 10.1038/nrmicro975
PubMed: 15372081
Links to Exploration step
pubmed:15372081Le document en format XML
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There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral infections such as HIV and hepatitis B and C, and the emergence of new viruses such as the SARS coronavirus. The potential danger of haemorrhagic fever viruses and eradicated viruses such as variola virus being used as bioterrorist weapons has also increased the profile of antiviral drug discovery. Here, the virus infections for which antiviral therapy is needed and the compounds that are available, or are being developed, for the treatment of these infections are described.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15372081</PMID><DateCompleted><Year>2004</Year><Month>10</Month><Day>06</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1740-1526</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><Issue>9</Issue><PubDate><Year>2004</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Nature reviews. Microbiology</Title><ISOAbbreviation>Nat. Rev. Microbiol.</ISOAbbreviation></Journal><ArticleTitle>Antivirals and antiviral strategies.</ArticleTitle><Pagination><MedlinePgn>704-20</MedlinePgn></Pagination><Abstract><AbstractText>In recent years, the demand for new antiviral strategies has increased markedly. 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