SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.
Identifieur interne : 002345 ( Ncbi/Checkpoint ); précédent : 002344; suivant : 002346SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.
Auteurs : Kulbhushan Sharma [Inde] ; Sara Kerström ; Anuj Kumar Sharma ; Vincent T K. Chow ; Shumein Teow ; Bernard Abrenica ; Stephanie A. Booth ; Timothy F. Booth ; Ali Mirazimi ; Sunil K. LalSource :
- PloS one [ 1932-6203 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Caryophérines (métabolisme), Cellules Vero, Cycle cellulaire, Diffusion, Espace intracellulaire (métabolisme), Maturation post-traductionnelle des protéines, Modèles biologiques, Noyau de la cellule (métabolisme), Protéines virales (métabolisme), Récepteurs cytoplasmiques et nucléaires (métabolisme), Signaux d'export nucléaire, Signaux de localisation nucléaire (métabolisme), Transfection, Transport de protéines, Transport nucléaire actif, Virus du SRAS (métabolisme).
- MESH :
- métabolisme : Caryophérines, Espace intracellulaire, Noyau de la cellule, Protéines virales, Récepteurs cytoplasmiques et nucléaires, Signaux de localisation nucléaire, Virus du SRAS.
- Animaux, Apoptose, Cellules Vero, Cycle cellulaire, Diffusion, Maturation post-traductionnelle des protéines, Modèles biologiques, Signaux d'export nucléaire, Transfection, Transport de protéines, Transport nucléaire actif.
English descriptors
- KwdEn :
- Active Transport, Cell Nucleus, Animals, Apoptosis, Cell Cycle, Cell Nucleus (metabolism), Chlorocebus aethiops, Diffusion, Intracellular Space (metabolism), Karyopherins (metabolism), Models, Biological, Nuclear Export Signals, Nuclear Localization Signals (metabolism), Protein Processing, Post-Translational, Protein Transport, Receptors, Cytoplasmic and Nuclear (metabolism), SARS Virus (metabolism), Transfection, Vero Cells, Viral Proteins (metabolism).
- MESH :
- chemical , metabolism : Karyopherins, Nuclear Localization Signals, Receptors, Cytoplasmic and Nuclear, Viral Proteins.
- metabolism : Cell Nucleus, Intracellular Space, SARS Virus.
- Active Transport, Cell Nucleus, Animals, Apoptosis, Cell Cycle, Chlorocebus aethiops, Diffusion, Models, Biological, Nuclear Export Signals, Protein Processing, Post-Translational, Protein Transport, Transfection, Vero Cells.
Abstract
9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning is not well understood.
DOI: 10.1371/journal.pone.0019436
PubMed: 21637748
Affiliations:
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- to stream Ncbi, to step Curation: 002345
Links to Exploration step
pubmed:21637748Le document en format XML
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Chow</name></author><author><name sortKey="Teow, Shumein" sort="Teow, Shumein" uniqKey="Teow S" first="Shumein" last="Teow">Shumein Teow</name></author><author><name sortKey="Abrenica, Bernard" sort="Abrenica, Bernard" uniqKey="Abrenica B" first="Bernard" last="Abrenica">Bernard Abrenica</name></author><author><name sortKey="Booth, Stephanie A" sort="Booth, Stephanie A" uniqKey="Booth S" first="Stephanie A" last="Booth">Stephanie A. Booth</name></author><author><name sortKey="Booth, Timothy F" sort="Booth, Timothy F" uniqKey="Booth T" first="Timothy F" last="Booth">Timothy F. Booth</name></author><author><name sortKey="Mirazimi, Ali" sort="Mirazimi, Ali" uniqKey="Mirazimi A" first="Ali" last="Mirazimi">Ali Mirazimi</name></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. 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Chow</name></author><author><name sortKey="Teow, Shumein" sort="Teow, Shumein" uniqKey="Teow S" first="Shumein" last="Teow">Shumein Teow</name></author><author><name sortKey="Abrenica, Bernard" sort="Abrenica, Bernard" uniqKey="Abrenica B" first="Bernard" last="Abrenica">Bernard Abrenica</name></author><author><name sortKey="Booth, Stephanie A" sort="Booth, Stephanie A" uniqKey="Booth S" first="Stephanie A" last="Booth">Stephanie A. Booth</name></author><author><name sortKey="Booth, Timothy F" sort="Booth, Timothy F" uniqKey="Booth T" first="Timothy F" last="Booth">Timothy F. Booth</name></author><author><name sortKey="Mirazimi, Ali" sort="Mirazimi, Ali" uniqKey="Mirazimi A" first="Ali" last="Mirazimi">Ali Mirazimi</name></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active Transport, Cell Nucleus</term><term>Animals</term><term>Apoptosis</term><term>Cell Cycle</term><term>Cell Nucleus (metabolism)</term><term>Chlorocebus aethiops</term><term>Diffusion</term><term>Intracellular Space (metabolism)</term><term>Karyopherins (metabolism)</term><term>Models, Biological</term><term>Nuclear Export Signals</term><term>Nuclear Localization Signals (metabolism)</term><term>Protein Processing, Post-Translational</term><term>Protein Transport</term><term>Receptors, Cytoplasmic and Nuclear (metabolism)</term><term>SARS Virus (metabolism)</term><term>Transfection</term><term>Vero Cells</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Caryophérines (métabolisme)</term><term>Cellules Vero</term><term>Cycle cellulaire</term><term>Diffusion</term><term>Espace intracellulaire (métabolisme)</term><term>Maturation post-traductionnelle des protéines</term><term>Modèles biologiques</term><term>Noyau de la cellule (métabolisme)</term><term>Protéines virales (métabolisme)</term><term>Récepteurs cytoplasmiques et nucléaires (métabolisme)</term><term>Signaux d'export nucléaire</term><term>Signaux de localisation nucléaire (métabolisme)</term><term>Transfection</term><term>Transport de protéines</term><term>Transport nucléaire actif</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Karyopherins</term><term>Nuclear Localization Signals</term><term>Receptors, Cytoplasmic and Nuclear</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>Intracellular Space</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Caryophérines</term><term>Espace intracellulaire</term><term>Noyau de la cellule</term><term>Protéines virales</term><term>Récepteurs cytoplasmiques et nucléaires</term><term>Signaux de localisation nucléaire</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Active Transport, Cell Nucleus</term><term>Animals</term><term>Apoptosis</term><term>Cell Cycle</term><term>Chlorocebus aethiops</term><term>Diffusion</term><term>Models, Biological</term><term>Nuclear Export Signals</term><term>Protein Processing, Post-Translational</term><term>Protein Transport</term><term>Transfection</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Cellules Vero</term><term>Cycle cellulaire</term><term>Diffusion</term><term>Maturation post-traductionnelle des protéines</term><term>Modèles biologiques</term><term>Signaux d'export nucléaire</term><term>Transfection</term><term>Transport de protéines</term><term>Transport nucléaire actif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning is not well understood.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey=" Kerstrom, Sara" sort=" Kerstrom, Sara" uniqKey=" Kerstrom S" first="Sara" last=" Kerström">Sara Kerström</name><name sortKey="Abrenica, Bernard" sort="Abrenica, Bernard" uniqKey="Abrenica B" first="Bernard" last="Abrenica">Bernard Abrenica</name><name sortKey="Booth, Stephanie A" sort="Booth, Stephanie A" uniqKey="Booth S" first="Stephanie A" last="Booth">Stephanie A. Booth</name><name sortKey="Booth, Timothy F" sort="Booth, Timothy F" uniqKey="Booth T" first="Timothy F" last="Booth">Timothy F. Booth</name><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name><name sortKey="Mirazimi, Ali" sort="Mirazimi, Ali" uniqKey="Mirazimi A" first="Ali" last="Mirazimi">Ali Mirazimi</name><name sortKey="Sharma, Anuj Kumar" sort="Sharma, Anuj Kumar" uniqKey="Sharma A" first="Anuj Kumar" last="Sharma">Anuj Kumar Sharma</name><name sortKey="Teow, Shumein" sort="Teow, Shumein" uniqKey="Teow S" first="Shumein" last="Teow">Shumein Teow</name></noCountry><country name="Inde"><noRegion><name sortKey="Sharma, Kulbhushan" sort="Sharma, Kulbhushan" uniqKey="Sharma K" first="Kulbhushan" last="Sharma">Kulbhushan Sharma</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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