SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.
Identifieur interne : 001436 ( PubMed/Checkpoint ); précédent : 001435; suivant : 001437SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.
Auteurs : Kulbhushan Sharma [Inde] ; Sara Kerström ; Anuj Kumar Sharma ; Vincent T K. Chow ; Shumein Teow ; Bernard Abrenica ; Stephanie A. Booth ; Timothy F. Booth ; Ali Mirazimi ; Sunil K. LalSource :
- PloS one [ 1932-6203 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Caryophérines (métabolisme), Cellules Vero, Cycle cellulaire, Diffusion, Espace intracellulaire (métabolisme), Maturation post-traductionnelle des protéines, Modèles biologiques, Noyau de la cellule (métabolisme), Protéines virales (métabolisme), Récepteurs cytoplasmiques et nucléaires (métabolisme), Signaux d'export nucléaire, Signaux de localisation nucléaire (métabolisme), Transfection, Transport de protéines, Transport nucléaire actif, Virus du SRAS (métabolisme).
- MESH :
- métabolisme : Caryophérines, Espace intracellulaire, Noyau de la cellule, Protéines virales, Récepteurs cytoplasmiques et nucléaires, Signaux de localisation nucléaire, Virus du SRAS.
- Animaux, Apoptose, Cellules Vero, Cycle cellulaire, Diffusion, Maturation post-traductionnelle des protéines, Modèles biologiques, Signaux d'export nucléaire, Transfection, Transport de protéines, Transport nucléaire actif.
English descriptors
- KwdEn :
- Active Transport, Cell Nucleus, Animals, Apoptosis, Cell Cycle, Cell Nucleus (metabolism), Chlorocebus aethiops, Diffusion, Intracellular Space (metabolism), Karyopherins (metabolism), Models, Biological, Nuclear Export Signals, Nuclear Localization Signals (metabolism), Protein Processing, Post-Translational, Protein Transport, Receptors, Cytoplasmic and Nuclear (metabolism), SARS Virus (metabolism), Transfection, Vero Cells, Viral Proteins (metabolism).
- MESH :
- chemical , metabolism : Karyopherins, Nuclear Localization Signals, Receptors, Cytoplasmic and Nuclear, Viral Proteins.
- metabolism : Cell Nucleus, Intracellular Space, SARS Virus.
- Active Transport, Cell Nucleus, Animals, Apoptosis, Cell Cycle, Chlorocebus aethiops, Diffusion, Models, Biological, Nuclear Export Signals, Protein Processing, Post-Translational, Protein Transport, Transfection, Vero Cells.
Abstract
9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning is not well understood.
DOI: 10.1371/journal.pone.0019436
PubMed: 21637748
Affiliations:
Links toward previous steps (curation, corpus...)
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pubmed:21637748Le document en format XML
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<term>Apoptosis</term>
<term>Cell Cycle</term>
<term>Cell Nucleus (metabolism)</term>
<term>Chlorocebus aethiops</term>
<term>Diffusion</term>
<term>Intracellular Space (metabolism)</term>
<term>Karyopherins (metabolism)</term>
<term>Models, Biological</term>
<term>Nuclear Export Signals</term>
<term>Nuclear Localization Signals (metabolism)</term>
<term>Protein Processing, Post-Translational</term>
<term>Protein Transport</term>
<term>Receptors, Cytoplasmic and Nuclear (metabolism)</term>
<term>SARS Virus (metabolism)</term>
<term>Transfection</term>
<term>Vero Cells</term>
<term>Viral Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Caryophérines (métabolisme)</term>
<term>Cellules Vero</term>
<term>Cycle cellulaire</term>
<term>Diffusion</term>
<term>Espace intracellulaire (métabolisme)</term>
<term>Maturation post-traductionnelle des protéines</term>
<term>Modèles biologiques</term>
<term>Noyau de la cellule (métabolisme)</term>
<term>Protéines virales (métabolisme)</term>
<term>Récepteurs cytoplasmiques et nucléaires (métabolisme)</term>
<term>Signaux d'export nucléaire</term>
<term>Signaux de localisation nucléaire (métabolisme)</term>
<term>Transfection</term>
<term>Transport de protéines</term>
<term>Transport nucléaire actif</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Karyopherins</term>
<term>Nuclear Localization Signals</term>
<term>Receptors, Cytoplasmic and Nuclear</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term>
<term>Intracellular Space</term>
<term>SARS Virus</term>
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<term>Espace intracellulaire</term>
<term>Noyau de la cellule</term>
<term>Protéines virales</term>
<term>Récepteurs cytoplasmiques et nucléaires</term>
<term>Signaux de localisation nucléaire</term>
<term>Virus du SRAS</term>
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<keywords scheme="MESH" xml:lang="en"><term>Active Transport, Cell Nucleus</term>
<term>Animals</term>
<term>Apoptosis</term>
<term>Cell Cycle</term>
<term>Chlorocebus aethiops</term>
<term>Diffusion</term>
<term>Models, Biological</term>
<term>Nuclear Export Signals</term>
<term>Protein Processing, Post-Translational</term>
<term>Protein Transport</term>
<term>Transfection</term>
<term>Vero Cells</term>
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<term>Apoptose</term>
<term>Cellules Vero</term>
<term>Cycle cellulaire</term>
<term>Diffusion</term>
<term>Maturation post-traductionnelle des protéines</term>
<term>Modèles biologiques</term>
<term>Signaux d'export nucléaire</term>
<term>Transfection</term>
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<front><div type="abstract" xml:lang="en">9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning is not well understood.</div>
</front>
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<Month>09</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
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<Issue>5</Issue>
<PubDate><Year>2011</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
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<ArticleTitle>SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.</ArticleTitle>
<Pagination><MedlinePgn>e19436</MedlinePgn>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning is not well understood.</AbstractText>
<AbstractText Label="PRINCIPAL FINDINGS/METHODOLOGY" NlmCategory="RESULTS">In this report, we demonstrate that 9b in the absence of any nuclear localization signal (NLS) enters the nucleus by passive transport. Using various cell cycle inhibitors, we have shown that the nuclear entry of 9b is independent of the cell cycle. Further, we found that 9b interacts with the cellular protein Crm1 and gets exported out of the nucleus using an active NES. We have also revealed that this NES activity influences the half-life of 9b and affects host cell death. We found that an export signal deficient SARS-CoV 9b protein induces apoptosis in transiently transfected cells and showed elevated caspase-3 activity.</AbstractText>
<AbstractText Label="CONCLUSION/SIGNIFICANCE" NlmCategory="CONCLUSIONS">Here, we showed that nuclear shuttling of 9b and its interaction with Crm1 are essential for the proper degradation of 9b and blocking the nuclear export of this protein induces apoptosis. This phenomenon may be critical in providing a novel role to the 9b accessory protein of SARS-CoV.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sharma</LastName>
<ForeName>Kulbhushan</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Åkerström</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sharma</LastName>
<ForeName>Anuj Kumar</ForeName>
<Initials>AK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chow</LastName>
<ForeName>Vincent T K</ForeName>
<Initials>VT</Initials>
</Author>
<Author ValidYN="Y"><LastName>Teow</LastName>
<ForeName>Shumein</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Abrenica</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Booth</LastName>
<ForeName>Stephanie A</ForeName>
<Initials>SA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Booth</LastName>
<ForeName>Timothy F</ForeName>
<Initials>TF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mirazimi</LastName>
<ForeName>Ali</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lal</LastName>
<ForeName>Sunil K</ForeName>
<Initials>SK</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D028884">Karyopherins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D049790">Nuclear Export Signals</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019913">Nuclear Localization Signals</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D021581" MajorTopicYN="N">Active Transport, Cell Nucleus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017209" MajorTopicYN="Y">Apoptosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002453" MajorTopicYN="N">Cell Cycle</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002467" MajorTopicYN="N">Cell Nucleus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049790" MajorTopicYN="N">Nuclear Export Signals</DescriptorName>
</MeshHeading>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018160" MajorTopicYN="N">Receptors, Cytoplasmic and Nuclear</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D014162" MajorTopicYN="N">Transfection</DescriptorName>
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<MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName>
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