SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.
Identifieur interne : 001506 ( PubMed/Corpus ); précédent : 001505; suivant : 001507SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.
Auteurs : Kulbhushan Sharma ; Sara Kerström ; Anuj Kumar Sharma ; Vincent T K. Chow ; Shumein Teow ; Bernard Abrenica ; Stephanie A. Booth ; Timothy F. Booth ; Ali Mirazimi ; Sunil K. LalSource :
- PloS one [ 1932-6203 ] ; 2011.
English descriptors
- KwdEn :
- Active Transport, Cell Nucleus, Animals, Apoptosis, Cell Cycle, Cell Nucleus (metabolism), Chlorocebus aethiops, Diffusion, Intracellular Space (metabolism), Karyopherins (metabolism), Models, Biological, Nuclear Export Signals, Nuclear Localization Signals (metabolism), Protein Processing, Post-Translational, Protein Transport, Receptors, Cytoplasmic and Nuclear (metabolism), SARS Virus (metabolism), Transfection, Vero Cells, Viral Proteins (metabolism).
- MESH :
- chemical , metabolism : Karyopherins, Nuclear Localization Signals, Receptors, Cytoplasmic and Nuclear, Viral Proteins.
- metabolism : Cell Nucleus, Intracellular Space, SARS Virus.
- Active Transport, Cell Nucleus, Animals, Apoptosis, Cell Cycle, Chlorocebus aethiops, Diffusion, Models, Biological, Nuclear Export Signals, Protein Processing, Post-Translational, Protein Transport, Transfection, Vero Cells.
Abstract
9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning is not well understood.
DOI: 10.1371/journal.pone.0019436
PubMed: 21637748
Links to Exploration step
pubmed:21637748Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.</title><author><name sortKey="Sharma, Kulbhushan" sort="Sharma, Kulbhushan" uniqKey="Sharma K" first="Kulbhushan" last="Sharma">Kulbhushan Sharma</name><affiliation><nlm:affiliation>Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey=" Kerstrom, Sara" sort=" Kerstrom, Sara" uniqKey=" Kerstrom S" first="Sara" last=" Kerström">Sara Kerström</name></author><author><name sortKey="Sharma, Anuj Kumar" sort="Sharma, Anuj Kumar" uniqKey="Sharma A" first="Anuj Kumar" last="Sharma">Anuj Kumar Sharma</name></author><author><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name></author><author><name sortKey="Teow, Shumein" sort="Teow, Shumein" uniqKey="Teow S" first="Shumein" last="Teow">Shumein Teow</name></author><author><name sortKey="Abrenica, Bernard" sort="Abrenica, Bernard" uniqKey="Abrenica B" first="Bernard" last="Abrenica">Bernard Abrenica</name></author><author><name sortKey="Booth, Stephanie A" sort="Booth, Stephanie A" uniqKey="Booth S" first="Stephanie A" last="Booth">Stephanie A. Booth</name></author><author><name sortKey="Booth, Timothy F" sort="Booth, Timothy F" uniqKey="Booth T" first="Timothy F" last="Booth">Timothy F. Booth</name></author><author><name sortKey="Mirazimi, Ali" sort="Mirazimi, Ali" uniqKey="Mirazimi A" first="Ali" last="Mirazimi">Ali Mirazimi</name></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21637748</idno><idno type="pmid">21637748</idno><idno type="doi">10.1371/journal.pone.0019436</idno><idno type="wicri:Area/PubMed/Corpus">001506</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001506</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.</title><author><name sortKey="Sharma, Kulbhushan" sort="Sharma, Kulbhushan" uniqKey="Sharma K" first="Kulbhushan" last="Sharma">Kulbhushan Sharma</name><affiliation><nlm:affiliation>Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey=" Kerstrom, Sara" sort=" Kerstrom, Sara" uniqKey=" Kerstrom S" first="Sara" last=" Kerström">Sara Kerström</name></author><author><name sortKey="Sharma, Anuj Kumar" sort="Sharma, Anuj Kumar" uniqKey="Sharma A" first="Anuj Kumar" last="Sharma">Anuj Kumar Sharma</name></author><author><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name></author><author><name sortKey="Teow, Shumein" sort="Teow, Shumein" uniqKey="Teow S" first="Shumein" last="Teow">Shumein Teow</name></author><author><name sortKey="Abrenica, Bernard" sort="Abrenica, Bernard" uniqKey="Abrenica B" first="Bernard" last="Abrenica">Bernard Abrenica</name></author><author><name sortKey="Booth, Stephanie A" sort="Booth, Stephanie A" uniqKey="Booth S" first="Stephanie A" last="Booth">Stephanie A. Booth</name></author><author><name sortKey="Booth, Timothy F" sort="Booth, Timothy F" uniqKey="Booth T" first="Timothy F" last="Booth">Timothy F. Booth</name></author><author><name sortKey="Mirazimi, Ali" sort="Mirazimi, Ali" uniqKey="Mirazimi A" first="Ali" last="Mirazimi">Ali Mirazimi</name></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active Transport, Cell Nucleus</term><term>Animals</term><term>Apoptosis</term><term>Cell Cycle</term><term>Cell Nucleus (metabolism)</term><term>Chlorocebus aethiops</term><term>Diffusion</term><term>Intracellular Space (metabolism)</term><term>Karyopherins (metabolism)</term><term>Models, Biological</term><term>Nuclear Export Signals</term><term>Nuclear Localization Signals (metabolism)</term><term>Protein Processing, Post-Translational</term><term>Protein Transport</term><term>Receptors, Cytoplasmic and Nuclear (metabolism)</term><term>SARS Virus (metabolism)</term><term>Transfection</term><term>Vero Cells</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Karyopherins</term><term>Nuclear Localization Signals</term><term>Receptors, Cytoplasmic and Nuclear</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>Intracellular Space</term><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Active Transport, Cell Nucleus</term><term>Animals</term><term>Apoptosis</term><term>Cell Cycle</term><term>Chlorocebus aethiops</term><term>Diffusion</term><term>Models, Biological</term><term>Nuclear Export Signals</term><term>Protein Processing, Post-Translational</term><term>Protein Transport</term><term>Transfection</term><term>Vero Cells</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning is not well understood.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21637748</PMID><DateCompleted><Year>2011</Year><Month>09</Month><Day>29</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>5</Issue><PubDate><Year>2011</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.</ArticleTitle><Pagination><MedlinePgn>e19436</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0019436</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning is not well understood.</AbstractText><AbstractText Label="PRINCIPAL FINDINGS/METHODOLOGY" NlmCategory="RESULTS">In this report, we demonstrate that 9b in the absence of any nuclear localization signal (NLS) enters the nucleus by passive transport. Using various cell cycle inhibitors, we have shown that the nuclear entry of 9b is independent of the cell cycle. Further, we found that 9b interacts with the cellular protein Crm1 and gets exported out of the nucleus using an active NES. We have also revealed that this NES activity influences the half-life of 9b and affects host cell death. We found that an export signal deficient SARS-CoV 9b protein induces apoptosis in transiently transfected cells and showed elevated caspase-3 activity.</AbstractText><AbstractText Label="CONCLUSION/SIGNIFICANCE" NlmCategory="CONCLUSIONS">Here, we showed that nuclear shuttling of 9b and its interaction with Crm1 are essential for the proper degradation of 9b and blocking the nuclear export of this protein induces apoptosis. This phenomenon may be critical in providing a novel role to the 9b accessory protein of SARS-CoV.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Kulbhushan</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Åkerström</LastName><ForeName>Sara</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Anuj Kumar</ForeName><Initials>AK</Initials></Author><Author ValidYN="Y"><LastName>Chow</LastName><ForeName>Vincent T K</ForeName><Initials>VT</Initials></Author><Author ValidYN="Y"><LastName>Teow</LastName><ForeName>Shumein</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Abrenica</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Booth</LastName><ForeName>Stephanie A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Booth</LastName><ForeName>Timothy F</ForeName><Initials>TF</Initials></Author><Author ValidYN="Y"><LastName>Mirazimi</LastName><ForeName>Ali</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lal</LastName><ForeName>Sunil K</ForeName><Initials>SK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>05</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D028884">Karyopherins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D049790">Nuclear Export Signals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019913">Nuclear Localization Signals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018160">Receptors, Cytoplasmic and Nuclear</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C078342">exportin 1 protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D021581" MajorTopicYN="N">Active Transport, Cell Nucleus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="Y">Apoptosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002453" MajorTopicYN="N">Cell Cycle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002467" MajorTopicYN="N">Cell Nucleus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004058" MajorTopicYN="N">Diffusion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042541" MajorTopicYN="N">Intracellular Space</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D028884" MajorTopicYN="N">Karyopherins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049790" MajorTopicYN="N">Nuclear Export Signals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019913" MajorTopicYN="N">Nuclear Localization Signals</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011499" MajorTopicYN="N">Protein Processing, Post-Translational</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018160" MajorTopicYN="N">Receptors, Cytoplasmic and Nuclear</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014162" 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