A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses
Identifieur interne : 001127 ( Ncbi/Checkpoint ); précédent : 001126; suivant : 001128A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses
Auteurs : Ali Azizi ; Susan Aucoin ; Helina Tadesse ; Rita Frost ; Masoud Ghorbani ; Catalina Soare ; Turaya Naas ; Francisco Diaz-MitomaSource :
- Genetic Vaccines and Therapy [ 1479-0556 ] ; 2005.
Abstract
Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses. Several groups of mice were immunized alone or in combination with SARS-nucleocapsid immunogen. A high level of specific SARS-CD8+ T-cell response was demonstrated in mice that received DNA encoding the SARS-nucleocapsid, protein and XIAP as an adjuvant. We also observed that co-administration of a plasmid expressing nucleocapsid, recombinant protein and montanide/CpG induces high antibody titers in immunized mice. Moreover, this vaccine approach merits further investigation as a potential candidate vaccine against SARS.
The online version of this article (doi:10.1186/1479-0556-3-7) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1479-0556-3-7
PubMed: 16115319
PubMed Central: 1249587
Affiliations:
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Canada</nlm:aff><wicri:noCountry code="subfield">ON K1H 8L1 Canada</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.28046.38</institution-id><institution-id institution-id-type="ISNI">0000000121822255</institution-id><institution>Department of Microbiology and Immunology, Faculty of Medicine,</institution><institution>University of Ottawa,</institution></institution-wrap>Ottawa, ON K1H 8M2 Canada</nlm:aff><wicri:noCountry code="subfield">ON K1H 8M2 Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">Genetic Vaccines and Therapy</title><idno type="eISSN">1479-0556</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses. Several groups of mice were immunized alone or in combination with SARS-nucleocapsid immunogen. A high level of specific SARS-CD8+ T-cell response was demonstrated in mice that received DNA encoding the SARS-nucleocapsid, protein and XIAP as an adjuvant. We also observed that co-administration of a plasmid expressing nucleocapsid, recombinant protein and montanide/CpG induces high antibody titers in immunized mice. Moreover, this vaccine approach merits further investigation as a potential candidate vaccine against SARS.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1479-0556-3-7) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Buchholz, Uj" uniqKey="Buchholz U">UJ Buchholz</name></author><author><name sortKey="Bukreyev, A" uniqKey="Bukreyev A">A Bukreyev</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spiga, O" uniqKey="Spiga O">O Spiga</name></author><author><name sortKey="Bernini, A" uniqKey="Bernini A">A Bernini</name></author><author><name sortKey="Ciutti, A" uniqKey="Ciutti A">A Ciutti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, H" uniqKey="Lu H">H 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Matsumoto</name></author><author><name sortKey="Hengge, Ur" uniqKey="Hengge U">UR Hengge</name></author><author><name sortKey="Chang, Yf" uniqKey="Chang Y">YF Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Tw" uniqKey="Kim T">TW Kim</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Hung, Cf" uniqKey="Hung C">CF Hung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Ms" uniqKey="Zhu M">MS Zhu</name></author><author><name sortKey="Pan, Y" uniqKey="Pan Y">Y Pan</name></author><author><name sortKey="Chen, Hq" uniqKey="Chen H">HQ Chen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aucoin, Susan" sort="Aucoin, Susan" uniqKey="Aucoin S" first="Susan" last="Aucoin">Susan Aucoin</name><name sortKey="Azizi, Ali" sort="Azizi, Ali" uniqKey="Azizi A" first="Ali" last="Azizi">Ali Azizi</name><name sortKey="Diaz Mitoma, Francisco" sort="Diaz Mitoma, Francisco" uniqKey="Diaz Mitoma F" first="Francisco" last="Diaz-Mitoma">Francisco Diaz-Mitoma</name><name sortKey="Frost, Rita" sort="Frost, Rita" uniqKey="Frost R" first="Rita" last="Frost">Rita Frost</name><name sortKey="Ghorbani, Masoud" sort="Ghorbani, Masoud" uniqKey="Ghorbani M" first="Masoud" last="Ghorbani">Masoud Ghorbani</name><name sortKey="Naas, Turaya" sort="Naas, Turaya" uniqKey="Naas T" first="Turaya" last="Naas">Turaya Naas</name><name sortKey="Soare, Catalina" sort="Soare, Catalina" uniqKey="Soare C" first="Catalina" last="Soare">Catalina Soare</name><name sortKey="Tadesse, Helina" sort="Tadesse, Helina" uniqKey="Tadesse H" first="Helina" last="Tadesse">Helina Tadesse</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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