The secret life of ACE2 as a receptor for the SARS virus.
Identifieur interne : 000505 ( Ncbi/Checkpoint ); précédent : 000504; suivant : 000506The secret life of ACE2 as a receptor for the SARS virus.
Auteurs : Dimiter S. Dimitrov [États-Unis]Source :
- Cell [ 0092-8674 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Carboxypeptidases, Protéines de fusion virale, Récepteurs de surface cellulaire, Virus du SRAS.
- physiologie : Fusion membranaire, Sites de fixation.
- Conformation des protéines, Peptidyl-Dipeptidase A.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Carboxypeptidases, Receptors, Cell Surface, Viral Fusion Proteins.
- metabolism : SARS Virus.
- physiology : Binding Sites, Membrane Fusion.
- chemical : Peptidyl-Dipeptidase A, Protein Conformation.
Abstract
The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.
DOI: 10.1016/s0092-8674(03)00976-0
PubMed: 14675530
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003044
- to stream PubMed, to step Curation: 003044
- to stream PubMed, to step Checkpoint: 003019
- to stream Ncbi, to step Merge: 000505
- to stream Ncbi, to step Curation: 000505
Links to Exploration step
pubmed:14675530Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The secret life of ACE2 as a receptor for the SARS virus.</title>
<author><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S" last="Dimitrov">Dimiter S. Dimitrov</name>
<affiliation wicri:level="2"><nlm:affiliation>Human Immunovirology and Computational Biology Group, LECB, CCR, NCI-Frederick, NIH, Frederick, MD 21702, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Human Immunovirology and Computational Biology Group, LECB, CCR, NCI-Frederick, NIH, Frederick, MD 21702</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2003">2003</date>
<idno type="RBID">pubmed:14675530</idno>
<idno type="pmid">14675530</idno>
<idno type="doi">10.1016/s0092-8674(03)00976-0</idno>
<idno type="wicri:Area/PubMed/Corpus">003044</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003044</idno>
<idno type="wicri:Area/PubMed/Curation">003044</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003044</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003019</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003019</idno>
<idno type="wicri:Area/Ncbi/Merge">000505</idno>
<idno type="wicri:Area/Ncbi/Curation">000505</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000505</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The secret life of ACE2 as a receptor for the SARS virus.</title>
<author><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S" last="Dimitrov">Dimiter S. Dimitrov</name>
<affiliation wicri:level="2"><nlm:affiliation>Human Immunovirology and Computational Biology Group, LECB, CCR, NCI-Frederick, NIH, Frederick, MD 21702, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Human Immunovirology and Computational Biology Group, LECB, CCR, NCI-Frederick, NIH, Frederick, MD 21702</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell</title>
<idno type="ISSN">0092-8674</idno>
<imprint><date when="2003" type="published">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Binding Sites (physiology)</term>
<term>Carboxypeptidases (metabolism)</term>
<term>Membrane Fusion (physiology)</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Protein Conformation</term>
<term>Receptors, Cell Surface (metabolism)</term>
<term>SARS Virus (metabolism)</term>
<term>Viral Fusion Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Carboxypeptidases (métabolisme)</term>
<term>Conformation des protéines</term>
<term>Fusion membranaire (physiologie)</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Protéines de fusion virale (métabolisme)</term>
<term>Récepteurs de surface cellulaire (métabolisme)</term>
<term>Sites de fixation (physiologie)</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carboxypeptidases</term>
<term>Receptors, Cell Surface</term>
<term>Viral Fusion Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carboxypeptidases</term>
<term>Protéines de fusion virale</term>
<term>Récepteurs de surface cellulaire</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Fusion membranaire</term>
<term>Sites de fixation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Binding Sites</term>
<term>Membrane Fusion</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Peptidyl-Dipeptidase A</term>
<term>Protein Conformation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Conformation des protéines</term>
<term>Peptidyl-Dipeptidase A</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S" last="Dimitrov">Dimiter S. Dimitrov</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000505 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000505 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= pubmed:14675530 |texte= The secret life of ACE2 as a receptor for the SARS virus. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:14675530" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |