The secret life of ACE2 as a receptor for the SARS virus.
Identifieur interne : 000505 ( Ncbi/Merge ); précédent : 000504; suivant : 000506The secret life of ACE2 as a receptor for the SARS virus.
Auteurs : Dimiter S. Dimitrov [États-Unis]Source :
- Cell [ 0092-8674 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Carboxypeptidases, Protéines de fusion virale, Récepteurs de surface cellulaire, Virus du SRAS.
- physiologie : Fusion membranaire, Sites de fixation.
- Conformation des protéines, Peptidyl-Dipeptidase A.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Carboxypeptidases, Receptors, Cell Surface, Viral Fusion Proteins.
- metabolism : SARS Virus.
- physiology : Binding Sites, Membrane Fusion.
- chemical : Peptidyl-Dipeptidase A, Protein Conformation.
Abstract
The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.
DOI: 10.1016/s0092-8674(03)00976-0
PubMed: 14675530
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pubmed:14675530Le document en format XML
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Dimitrov</name><affiliation wicri:level="2"><nlm:affiliation>Human Immunovirology and Computational Biology Group, LECB, CCR, NCI-Frederick, NIH, Frederick, MD 21702, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Immunovirology and Computational Biology Group, LECB, CCR, NCI-Frederick, NIH, Frederick, MD 21702</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">Cell</title><idno type="ISSN">0092-8674</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Binding Sites (physiology)</term><term>Carboxypeptidases (metabolism)</term><term>Membrane Fusion (physiology)</term><term>Peptidyl-Dipeptidase A</term><term>Protein Conformation</term><term>Receptors, Cell Surface (metabolism)</term><term>SARS Virus (metabolism)</term><term>Viral Fusion Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Carboxypeptidases (métabolisme)</term><term>Conformation des protéines</term><term>Fusion membranaire (physiologie)</term><term>Peptidyl-Dipeptidase A</term><term>Protéines de fusion virale (métabolisme)</term><term>Récepteurs de surface cellulaire (métabolisme)</term><term>Sites de fixation (physiologie)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carboxypeptidases</term><term>Receptors, Cell Surface</term><term>Viral Fusion Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carboxypeptidases</term><term>Protéines de fusion virale</term><term>Récepteurs de surface cellulaire</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Fusion membranaire</term><term>Sites de fixation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Binding Sites</term><term>Membrane Fusion</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Protein Conformation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Conformation des protéines</term><term>Peptidyl-Dipeptidase A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. 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