The secret life of ACE2 as a receptor for the SARS virus.
Identifieur interne : 003019 ( PubMed/Checkpoint ); précédent : 003018; suivant : 003020The secret life of ACE2 as a receptor for the SARS virus.
Auteurs : Dimiter S. Dimitrov [États-Unis]Source :
- Cell [ 0092-8674 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Carboxypeptidases, Protéines de fusion virale, Récepteurs de surface cellulaire, Virus du SRAS.
- physiologie : Fusion membranaire, Sites de fixation.
- Conformation des protéines, Peptidyl-Dipeptidase A.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Carboxypeptidases, Receptors, Cell Surface, Viral Fusion Proteins.
- metabolism : SARS Virus.
- physiology : Binding Sites, Membrane Fusion.
- chemical : Peptidyl-Dipeptidase A, Protein Conformation.
Abstract
The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.
DOI: 10.1016/s0092-8674(03)00976-0
PubMed: 14675530
Affiliations:
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pubmed:14675530Le document en format XML
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<term>Carboxypeptidases (metabolism)</term>
<term>Membrane Fusion (physiology)</term>
<term>Peptidyl-Dipeptidase A</term>
<term>Protein Conformation</term>
<term>Receptors, Cell Surface (metabolism)</term>
<term>SARS Virus (metabolism)</term>
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<term>Conformation des protéines</term>
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<term>Peptidyl-Dipeptidase A</term>
<term>Protéines de fusion virale (métabolisme)</term>
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<term>Protéines de fusion virale</term>
<term>Récepteurs de surface cellulaire</term>
<term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Fusion membranaire</term>
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<term>Protein Conformation</term>
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<front><div type="abstract" xml:lang="en">The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.</div>
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