Synthetic peptide studies on the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein: perspective for SARS vaccine development.
Identifieur interne : 005406 ( Main/Merge ); précédent : 005405; suivant : 005407Synthetic peptide studies on the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein: perspective for SARS vaccine development.
Auteurs : Wai-Yan Choy [République populaire de Chine] ; Shu-Guang Lin ; Paul Kay-Sheung Chan ; John Siu-Lun Tam ; Y M Dennis Lo ; Ida Miu-Ting Chu ; Sau-Na Tsai ; Ming-Qi Zhong ; Kwok-Pui Fung ; Mary Miu-Yee Waye ; Stephen Kwok-Wing Tsui ; Kai-On Ng ; Zhi-Xin Shan ; Min Yang ; Yi-Long Wu ; Zhan-Yi Lin ; Sai-Ming NgaiSource :
- Clinical chemistry [ 0009-9147 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Données de séquences moléculaires, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (immunologie), Haplorhini, Lapins, Microscopie confocale, Microscopie de fluorescence, Peptides (), Peptides (immunologie), Peptides (synthèse chimique), Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (immunologie), Séquence d'acides aminés, Test ELISA, Vaccination, Vaccins antiviraux (immunologie), Virus du SRAS (immunologie).
- MESH :
- immunologie : Glycoprotéines membranaires, Peptides, Protéines de l'enveloppe virale, Vaccins antiviraux, Virus du SRAS.
- synthèse chimique : Peptides.
- Animaux, Données de séquences moléculaires, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Haplorhini, Lapins, Microscopie confocale, Microscopie de fluorescence, Peptides, Protéines de l'enveloppe virale, Séquence d'acides aminés, Test ELISA, Vaccination.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Enzyme-Linked Immunosorbent Assay, Haplorhini, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (immunology), Microscopy, Confocal, Microscopy, Fluorescence, Molecular Sequence Data, Peptides (chemical synthesis), Peptides (chemistry), Peptides (immunology), Rabbits, SARS Virus (immunology), Spike Glycoprotein, Coronavirus, Vaccination, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , chemical synthesis : Peptides.
- chemical , chemistry : Membrane Glycoproteins, Peptides, Viral Envelope Proteins.
- chemical , immunology : Membrane Glycoproteins, Peptides, Viral Envelope Proteins, Viral Vaccines.
- immunology : SARS Virus.
- Amino Acid Sequence, Animals, Enzyme-Linked Immunosorbent Assay, Haplorhini, Microscopy, Confocal, Microscopy, Fluorescence, Molecular Sequence Data, Rabbits, Spike Glycoprotein, Coronavirus, Vaccination.
Abstract
The S (spike) protein of the etiologic coronavirus (CoV) agent of severe acute respiratory syndrome (SARS) plays a central role in mediating viral infection via receptor binding and membrane fusion between the virion and the host cell. We focused on using synthetic peptides for developing antibodies against SARS-CoV, which aimed to block viral invasion by eliciting an immune response specific to the native SARS-CoV S protein.
DOI: 10.1373/clinchem.2003.029801
PubMed: 15044316
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pubmed:15044316Le document en format XML
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<term>Membrane Glycoproteins (chemistry)</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>Microscopy, Confocal</term>
<term>Microscopy, Fluorescence</term>
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<term>Peptides (chemistry)</term>
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<term>Viral Vaccines (immunology)</term>
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<term>Microscopie confocale</term>
<term>Microscopie de fluorescence</term>
<term>Peptides ()</term>
<term>Peptides (immunologie)</term>
<term>Peptides (synthèse chimique)</term>
<term>Protéines de l'enveloppe virale ()</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Séquence d'acides aminés</term>
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<term>Vaccination</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Virus du SRAS (immunologie)</term>
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<term>Protéines de l'enveloppe virale</term>
<term>Vaccins antiviraux</term>
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<term>Enzyme-Linked Immunosorbent Assay</term>
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<term>Microscopy, Confocal</term>
<term>Microscopy, Fluorescence</term>
<term>Molecular Sequence Data</term>
<term>Rabbits</term>
<term>Spike Glycoprotein, Coronavirus</term>
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<term>Glycoprotéines membranaires</term>
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<term>Lapins</term>
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<term>Microscopie de fluorescence</term>
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<term>Protéines de l'enveloppe virale</term>
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<front><div type="abstract" xml:lang="en">The S (spike) protein of the etiologic coronavirus (CoV) agent of severe acute respiratory syndrome (SARS) plays a central role in mediating viral infection via receptor binding and membrane fusion between the virion and the host cell. We focused on using synthetic peptides for developing antibodies against SARS-CoV, which aimed to block viral invasion by eliciting an immune response specific to the native SARS-CoV S protein.</div>
</front>
</TEI>
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