Synthetic peptide studies on the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein: perspective for SARS vaccine development.
Identifieur interne : 000719 ( Ncbi/Checkpoint ); précédent : 000718; suivant : 000720Synthetic peptide studies on the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein: perspective for SARS vaccine development.
Auteurs : Wai-Yan Choy [République populaire de Chine] ; Shu-Guang Lin ; Paul Kay-Sheung Chan ; John Siu-Lun Tam ; Y M Dennis Lo ; Ida Miu-Ting Chu ; Sau-Na Tsai ; Ming-Qi Zhong ; Kwok-Pui Fung ; Mary Miu-Yee Waye ; Stephen Kwok-Wing Tsui ; Kai-On Ng ; Zhi-Xin Shan ; Min Yang ; Yi-Long Wu ; Zhan-Yi Lin ; Sai-Ming NgaiSource :
- Clinical chemistry [ 0009-9147 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Données de séquences moléculaires, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (immunologie), Haplorhini, Lapins, Microscopie confocale, Microscopie de fluorescence, Peptides (), Peptides (immunologie), Peptides (synthèse chimique), Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (immunologie), Séquence d'acides aminés, Test ELISA, Vaccination, Vaccins antiviraux (immunologie), Virus du SRAS (immunologie).
- MESH :
- immunologie : Glycoprotéines membranaires, Peptides, Protéines de l'enveloppe virale, Vaccins antiviraux, Virus du SRAS.
- synthèse chimique : Peptides.
- Animaux, Données de séquences moléculaires, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Haplorhini, Lapins, Microscopie confocale, Microscopie de fluorescence, Peptides, Protéines de l'enveloppe virale, Séquence d'acides aminés, Test ELISA, Vaccination.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Enzyme-Linked Immunosorbent Assay, Haplorhini, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (immunology), Microscopy, Confocal, Microscopy, Fluorescence, Molecular Sequence Data, Peptides (chemical synthesis), Peptides (chemistry), Peptides (immunology), Rabbits, SARS Virus (immunology), Spike Glycoprotein, Coronavirus, Vaccination, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , chemical synthesis : Peptides.
- chemical , chemistry : Membrane Glycoproteins, Peptides, Viral Envelope Proteins.
- chemical , immunology : Membrane Glycoproteins, Peptides, Viral Envelope Proteins, Viral Vaccines.
- immunology : SARS Virus.
- Amino Acid Sequence, Animals, Enzyme-Linked Immunosorbent Assay, Haplorhini, Microscopy, Confocal, Microscopy, Fluorescence, Molecular Sequence Data, Rabbits, Spike Glycoprotein, Coronavirus, Vaccination.
Abstract
The S (spike) protein of the etiologic coronavirus (CoV) agent of severe acute respiratory syndrome (SARS) plays a central role in mediating viral infection via receptor binding and membrane fusion between the virion and the host cell. We focused on using synthetic peptides for developing antibodies against SARS-CoV, which aimed to block viral invasion by eliciting an immune response specific to the native SARS-CoV S protein.
DOI: 10.1373/clinchem.2003.029801
PubMed: 15044316
Affiliations:
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pubmed:15044316Le document en format XML
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xml:lang="en">Synthetic peptide studies on the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein: perspective for SARS vaccine development.</title><author><name sortKey="Choy, Wai Yan" sort="Choy, Wai Yan" uniqKey="Choy W" first="Wai-Yan" last="Choy">Wai-Yan Choy</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Biotechnology Program, Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Molecular Biotechnology Program, Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Lin, Shu Guang" sort="Lin, Shu Guang" uniqKey="Lin S" first="Shu-Guang" last="Lin">Shu-Guang Lin</name></author><author><name sortKey="Chan, Paul Kay Sheung" sort="Chan, Paul Kay Sheung" uniqKey="Chan P" first="Paul Kay-Sheung" last="Chan">Paul Kay-Sheung Chan</name></author><author><name sortKey="Tam, John Siu Lun" sort="Tam, John Siu Lun" uniqKey="Tam J" first="John Siu-Lun" last="Tam">John Siu-Lun Tam</name></author><author><name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y M Dennis" last="Lo">Y M Dennis Lo</name></author><author><name sortKey="Chu, Ida Miu Ting" sort="Chu, Ida Miu Ting" uniqKey="Chu I" first="Ida Miu-Ting" last="Chu">Ida Miu-Ting Chu</name></author><author><name sortKey="Tsai, Sau Na" sort="Tsai, Sau Na" uniqKey="Tsai S" first="Sau-Na" last="Tsai">Sau-Na Tsai</name></author><author><name sortKey="Zhong, Ming Qi" sort="Zhong, Ming Qi" uniqKey="Zhong M" first="Ming-Qi" last="Zhong">Ming-Qi Zhong</name></author><author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name></author><author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name></author><author><name sortKey="Tsui, Stephen Kwok Wing" sort="Tsui, Stephen Kwok Wing" uniqKey="Tsui S" first="Stephen Kwok-Wing" last="Tsui">Stephen Kwok-Wing Tsui</name></author><author><name sortKey="Ng, Kai On" sort="Ng, Kai On" uniqKey="Ng K" first="Kai-On" last="Ng">Kai-On Ng</name></author><author><name sortKey="Shan, Zhi Xin" sort="Shan, Zhi Xin" uniqKey="Shan Z" first="Zhi-Xin" last="Shan">Zhi-Xin Shan</name></author><author><name sortKey="Yang, Min" sort="Yang, Min" uniqKey="Yang M" first="Min" last="Yang">Min Yang</name></author><author><name sortKey="Wu, Yi Long" sort="Wu, Yi Long" uniqKey="Wu Y" first="Yi-Long" last="Wu">Yi-Long Wu</name></author><author><name sortKey="Lin, Zhan Yi" sort="Lin, Zhan Yi" uniqKey="Lin Z" first="Zhan-Yi" last="Lin">Zhan-Yi Lin</name></author><author><name sortKey="Ngai, Sai Ming" sort="Ngai, Sai Ming" uniqKey="Ngai S" first="Sai-Ming" last="Ngai">Sai-Ming Ngai</name></author></analytic><series><title level="j">Clinical chemistry</title><idno type="ISSN">0009-9147</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Haplorhini</term><term>Membrane Glycoproteins (chemistry)</term><term>Membrane Glycoproteins (immunology)</term><term>Microscopy, Confocal</term><term>Microscopy, Fluorescence</term><term>Molecular Sequence Data</term><term>Peptides (chemical synthesis)</term><term>Peptides (chemistry)</term><term>Peptides (immunology)</term><term>Rabbits</term><term>SARS Virus (immunology)</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccination</term><term>Viral Envelope Proteins (chemistry)</term><term>Viral Envelope Proteins (immunology)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires ()</term><term>Glycoprotéines membranaires (immunologie)</term><term>Haplorhini</term><term>Lapins</term><term>Microscopie confocale</term><term>Microscopie de fluorescence</term><term>Peptides ()</term><term>Peptides (immunologie)</term><term>Peptides (synthèse chimique)</term><term>Protéines de l'enveloppe virale ()</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Séquence d'acides aminés</term><term>Test ELISA</term><term>Vaccination</term><term>Vaccins antiviraux (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Membrane Glycoproteins</term><term>Peptides</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term><term>Peptides</term><term>Viral Envelope Proteins</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Peptides</term><term>Protéines de l'enveloppe virale</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Peptides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Haplorhini</term><term>Microscopy, Confocal</term><term>Microscopy, Fluorescence</term><term>Molecular Sequence Data</term><term>Rabbits</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires</term><term>Haplorhini</term><term>Lapins</term><term>Microscopie confocale</term><term>Microscopie de fluorescence</term><term>Peptides</term><term>Protéines de l'enveloppe virale</term><term>Séquence d'acides aminés</term><term>Test ELISA</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The S (spike) protein of the etiologic coronavirus (CoV) agent of severe acute respiratory syndrome (SARS) plays a central role in mediating viral infection via receptor binding and membrane fusion between the virion and the host cell. We focused on using synthetic peptides for developing antibodies against SARS-CoV, which aimed to block viral invasion by eliciting an immune response specific to the native SARS-CoV S protein.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Chan, Paul Kay Sheung" sort="Chan, Paul Kay Sheung" uniqKey="Chan P" first="Paul Kay-Sheung" last="Chan">Paul Kay-Sheung Chan</name><name sortKey="Chu, Ida Miu Ting" sort="Chu, Ida Miu Ting" uniqKey="Chu I" first="Ida Miu-Ting" last="Chu">Ida Miu-Ting Chu</name><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name><name sortKey="Lin, Shu Guang" sort="Lin, Shu Guang" uniqKey="Lin S" first="Shu-Guang" last="Lin">Shu-Guang Lin</name><name sortKey="Lin, Zhan Yi" sort="Lin, Zhan Yi" uniqKey="Lin Z" first="Zhan-Yi" last="Lin">Zhan-Yi Lin</name><name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y M Dennis" last="Lo">Y M Dennis Lo</name><name sortKey="Ng, Kai On" sort="Ng, Kai On" uniqKey="Ng K" first="Kai-On" last="Ng">Kai-On Ng</name><name sortKey="Ngai, Sai Ming" sort="Ngai, Sai Ming" uniqKey="Ngai S" first="Sai-Ming" last="Ngai">Sai-Ming Ngai</name><name sortKey="Shan, Zhi Xin" sort="Shan, Zhi Xin" uniqKey="Shan Z" first="Zhi-Xin" last="Shan">Zhi-Xin Shan</name><name sortKey="Tam, John Siu Lun" sort="Tam, John Siu Lun" uniqKey="Tam J" first="John Siu-Lun" last="Tam">John Siu-Lun Tam</name><name sortKey="Tsai, Sau Na" sort="Tsai, Sau Na" uniqKey="Tsai S" first="Sau-Na" last="Tsai">Sau-Na Tsai</name><name sortKey="Tsui, Stephen Kwok Wing" sort="Tsui, Stephen Kwok Wing" uniqKey="Tsui S" first="Stephen Kwok-Wing" last="Tsui">Stephen Kwok-Wing Tsui</name><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name><name sortKey="Wu, Yi Long" sort="Wu, Yi Long" uniqKey="Wu Y" first="Yi-Long" last="Wu">Yi-Long Wu</name><name sortKey="Yang, Min" sort="Yang, Min" uniqKey="Yang M" first="Min" last="Yang">Min Yang</name><name sortKey="Zhong, Ming Qi" sort="Zhong, Ming Qi" uniqKey="Zhong M" first="Ming-Qi" last="Zhong">Ming-Qi Zhong</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Choy, Wai Yan" sort="Choy, Wai Yan" uniqKey="Choy W" first="Wai-Yan" last="Choy">Wai-Yan Choy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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