Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection
Identifieur interne : 005219 ( Main/Merge ); précédent : 005218; suivant : 005220Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection
Auteurs : HONGXING ZHANG [République populaire de Chine] ; GANGQIAO ZHOU [République populaire de Chine] ; LIANTENG ZHI [République populaire de Chine] ; HAO YANG [République populaire de Chine] ; YUN ZHAI [République populaire de Chine] ; XIAOJIA DONG [République populaire de Chine] ; XIUMEI ZHANG [République populaire de Chine] ; XUE GAO [République populaire de Chine] ; YUNPING ZHU [République populaire de Chine] ; FUCHU HE [République populaire de Chine]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2005.
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- Pascal (Inist)
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Abstract
Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.
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last="Yunping Zhu">YUNPING ZHU</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Fuchu He" sort="Fuchu He" uniqKey="Fuchu He" last="Fuchu He">FUCHU HE</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement 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aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Biophysics, Chinese Academy of Science</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gangqiao Zhou" sort="Gangqiao Zhou" uniqKey="Gangqiao Zhou" last="Gangqiao Zhou">GANGQIAO ZHOU</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lianteng Zhi" sort="Lianteng Zhi" uniqKey="Lianteng Zhi" last="Lianteng Zhi">LIANTENG ZHI</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hao Yang" sort="Hao Yang" uniqKey="Hao Yang" last="Hao Yang">HAO YANG</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yun Zhai" sort="Yun Zhai" uniqKey="Yun Zhai" last="Yun Zhai">YUN ZHAI</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xiaojia Dong" sort="Xiaojia Dong" uniqKey="Xiaojia Dong" last="Xiaojia Dong">XIAOJIA DONG</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xiumei Zhang" sort="Xiumei Zhang" uniqKey="Xiumei Zhang" last="Xiumei Zhang">XIUMEI ZHANG</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xue Gao" sort="Xue Gao" uniqKey="Xue Gao" last="Xue Gao">XUE GAO</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yunping Zhu" sort="Yunping Zhu" uniqKey="Yunping Zhu" last="Yunping Zhu">YUNPING ZHU</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Fuchu He" sort="Fuchu He" uniqKey="Fuchu He" last="Fuchu He">FUCHU HE</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Biomedical Sciences, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Infection</term><term>Lectin</term><term>Mannose</term><term>Microbiology</term><term>Polymorphism</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Mannose</term><term>Lectine</term><term>Polymorphisme</term><term>Microbiologie</term><term>Infection</term><term>Syndrome respiratoire aigu sévère</term><term>Association genetique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Hongxing Zhang" sort="Hongxing Zhang" uniqKey="Hongxing Zhang" last="Hongxing Zhang">HONGXING ZHANG</name></noRegion><name sortKey="Fuchu He" sort="Fuchu He" uniqKey="Fuchu He" last="Fuchu He">FUCHU HE</name><name sortKey="Fuchu He" sort="Fuchu He" uniqKey="Fuchu He" last="Fuchu He">FUCHU HE</name><name sortKey="Fuchu He" sort="Fuchu He" uniqKey="Fuchu He" last="Fuchu He">FUCHU HE</name><name sortKey="Gangqiao Zhou" sort="Gangqiao Zhou" uniqKey="Gangqiao Zhou" last="Gangqiao Zhou">GANGQIAO ZHOU</name><name sortKey="Gangqiao Zhou" sort="Gangqiao Zhou" uniqKey="Gangqiao Zhou" last="Gangqiao Zhou">GANGQIAO ZHOU</name><name sortKey="Hao Yang" sort="Hao Yang" uniqKey="Hao Yang" last="Hao Yang">HAO YANG</name><name sortKey="Hao Yang" sort="Hao Yang" uniqKey="Hao Yang" last="Hao Yang">HAO YANG</name><name sortKey="Hongxing Zhang" sort="Hongxing Zhang" uniqKey="Hongxing Zhang" last="Hongxing Zhang">HONGXING ZHANG</name><name sortKey="Hongxing Zhang" sort="Hongxing Zhang" uniqKey="Hongxing Zhang" last="Hongxing Zhang">HONGXING ZHANG</name><name sortKey="Lianteng Zhi" sort="Lianteng Zhi" uniqKey="Lianteng Zhi" last="Lianteng Zhi">LIANTENG ZHI</name><name sortKey="Lianteng Zhi" sort="Lianteng Zhi" uniqKey="Lianteng Zhi" last="Lianteng Zhi">LIANTENG ZHI</name><name sortKey="Xiaojia Dong" sort="Xiaojia Dong" uniqKey="Xiaojia Dong" last="Xiaojia Dong">XIAOJIA DONG</name><name sortKey="Xiumei Zhang" sort="Xiumei Zhang" uniqKey="Xiumei Zhang" last="Xiumei Zhang">XIUMEI ZHANG</name><name sortKey="Xue Gao" sort="Xue Gao" uniqKey="Xue Gao" last="Xue Gao">XUE GAO</name><name sortKey="Yun Zhai" sort="Yun Zhai" uniqKey="Yun Zhai" last="Yun Zhai">YUN ZHAI</name><name sortKey="Yun Zhai" sort="Yun Zhai" uniqKey="Yun Zhai" last="Yun Zhai">YUN ZHAI</name><name sortKey="Yunping Zhu" sort="Yunping Zhu" uniqKey="Yunping Zhu" last="Yunping Zhu">YUNPING ZHU</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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