Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection
Identifieur interne : 000415 ( PascalFrancis/Curation ); précédent : 000414; suivant : 000416Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection
Auteurs : HONGXING ZHANG [République populaire de Chine] ; GANGQIAO ZHOU [République populaire de Chine] ; LIANTENG ZHI [République populaire de Chine] ; HAO YANG [République populaire de Chine] ; YUN ZHAI [République populaire de Chine] ; XIAOJIA DONG [République populaire de Chine] ; XIUMEI ZHANG [République populaire de Chine] ; XUE GAO [République populaire de Chine] ; YUNPING ZHU [République populaire de Chine] ; FUCHU HE [République populaire de Chine]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2005.
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- Pascal (Inist)
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Abstract
Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection</title><author><name sortKey="Hongxing Zhang" sort="Hongxing Zhang" uniqKey="Hongxing Zhang" last="Hongxing Zhang">HONGXING ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biophysics, Chinese Academy of Science</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Gangqiao Zhou" sort="Gangqiao Zhou" uniqKey="Gangqiao Zhou" last="Gangqiao Zhou">GANGQIAO ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Lianteng Zhi" sort="Lianteng Zhi" uniqKey="Lianteng Zhi" last="Lianteng Zhi">LIANTENG ZHI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Hao Yang" sort="Hao Yang" uniqKey="Hao Yang" last="Hao Yang">HAO YANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yun Zhai" sort="Yun Zhai" uniqKey="Yun Zhai" last="Yun Zhai">YUN ZHAI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xiaojia Dong" sort="Xiaojia Dong" uniqKey="Xiaojia Dong" last="Xiaojia Dong">XIAOJIA DONG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xiumei Zhang" sort="Xiumei Zhang" uniqKey="Xiumei Zhang" last="Xiumei Zhang">XIUMEI ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xue Gao" sort="Xue Gao" uniqKey="Xue Gao" last="Xue Gao">XUE GAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yunping Zhu" sort="Yunping Zhu" uniqKey="Yunping Zhu" last="Yunping Zhu">YUNPING ZHU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Fuchu He" sort="Fuchu He" uniqKey="Fuchu He" last="Fuchu He">FUCHU HE</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Biomedical Sciences, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0492671</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0492671 INIST</idno><idno type="RBID">Pascal:05-0492671</idno><idno type="wicri:Area/PascalFrancis/Corpus">000575</idno><idno type="wicri:Area/PascalFrancis/Curation">000415</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection</title><author><name sortKey="Hongxing Zhang" sort="Hongxing Zhang" uniqKey="Hongxing Zhang" last="Hongxing Zhang">HONGXING ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Biophysics, Chinese Academy of Science</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Gangqiao Zhou" sort="Gangqiao Zhou" uniqKey="Gangqiao Zhou" last="Gangqiao Zhou">GANGQIAO ZHOU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Lianteng Zhi" sort="Lianteng Zhi" uniqKey="Lianteng Zhi" last="Lianteng Zhi">LIANTENG ZHI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Hao Yang" sort="Hao Yang" uniqKey="Hao Yang" last="Hao Yang">HAO YANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yun Zhai" sort="Yun Zhai" uniqKey="Yun Zhai" last="Yun Zhai">YUN ZHAI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xiaojia Dong" sort="Xiaojia Dong" uniqKey="Xiaojia Dong" last="Xiaojia Dong">XIAOJIA DONG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xiumei Zhang" sort="Xiumei Zhang" uniqKey="Xiumei Zhang" last="Xiumei Zhang">XIUMEI ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Xue Gao" sort="Xue Gao" uniqKey="Xue Gao" last="Xue Gao">XUE GAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Yunping Zhu" sort="Yunping Zhu" uniqKey="Yunping Zhu" last="Yunping Zhu">YUNPING ZHU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Fuchu He" sort="Fuchu He" uniqKey="Fuchu He" last="Fuchu He">FUCHU HE</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Biomedical Sciences, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Infection</term><term>Lectin</term><term>Mannose</term><term>Microbiology</term><term>Polymorphism</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Mannose</term><term>Lectine</term><term>Polymorphisme</term><term>Microbiologie</term><term>Infection</term><term>Syndrome respiratoire aigu sévère</term><term>Association genetique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1899</s0></fA01><fA02 i1="01"><s0>JIDIAQ</s0></fA02><fA03 i2="1"><s0>J. infect. dis.</s0></fA03><fA05><s2>192</s2></fA05><fA06><s2>8</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection</s1></fA08><fA11 i1="01" i2="1"><s1>HONGXING ZHANG</s1></fA11><fA11 i1="02" i2="1"><s1>GANGQIAO ZHOU</s1></fA11><fA11 i1="03" i2="1"><s1>LIANTENG ZHI</s1></fA11><fA11 i1="04" i2="1"><s1>HAO YANG</s1></fA11><fA11 i1="05" i2="1"><s1>YUN ZHAI</s1></fA11><fA11 i1="06" i2="1"><s1>XIAOJIA DONG</s1></fA11><fA11 i1="07" i2="1"><s1>XIUMEI ZHANG</s1></fA11><fA11 i1="08" i2="1"><s1>XUE GAO</s1></fA11><fA11 i1="09" i2="1"><s1>YUNPING ZHU</s1></fA11><fA11 i1="10" i2="1"><s1>FUCHU HE</s1></fA11><fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="03"><s1>Institute of Biophysics, Chinese Academy of Science</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ></fA14><fA14 i1="04"><s1>Institute of Biomedical Sciences, Fudan University</s1><s2>Shanghai</s2><s3>CHN</s3><sZ>10 aut.</sZ></fA14><fA20><s1>1355-1361</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>2052</s2><s5>354000131975050060</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>39 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0492671</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>The Journal of infectious diseases</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05C10</s0></fC02><fC02 i1="02" i2="X"><s0>002B05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Mannose</s0><s2>NK</s2><s5>05</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Mannose</s0><s2>NK</s2><s5>05</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Manosa</s0><s2>NK</s2><s5>05</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Lectine</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Lectin</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Lectina</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Polymorphisme</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Polymorphism</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Polimorfismo</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Microbiologie</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Microbiology</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Microbiología</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Infection</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Infection</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Infección</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0><s2>NM</s2><s5>14</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Association genetique</s0><s4>INC</s4><s5>79</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0><s5>13</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>13</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>13</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Poumon pathologie</s0><s5>16</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Lung disease</s0><s5>16</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Pulmón patología</s0><s5>16</s5></fC07><fN21><s1>346</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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