Identification of Novel Subgenomic RNAs and Noncanonical Transcription Initiation Signals of Severe Acute Respiratory Syndrome Coronavirus
Identifieur interne : 004A98 ( Main/Merge ); précédent : 004A97; suivant : 004A99Identification of Novel Subgenomic RNAs and Noncanonical Transcription Initiation Signals of Severe Acute Respiratory Syndrome Coronavirus
Auteurs : Snawar Hussain [République populaire de Chine] ; Ji'An Pan [République populaire de Chine] ; Yu Chen ; Yalin Yang [République populaire de Chine] ; Jing Xu [République populaire de Chine] ; Yu Peng ; Ying Wu [République populaire de Chine] ; Zhaoyang Li [République populaire de Chine] ; Ying Zhu [République populaire de Chine] ; Po Tien [République populaire de Chine] ; Deyin Guo [République populaire de Chine]Source :
- Journal of Virology [ 0022-538X ] ; 2005.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN viral (biosynthèse), ARN viral (génétique), Animaux, Cadres ouverts de lecture, Cellules Vero, Cricetinae, Données de séquences moléculaires, Génome viral, Matrices (génétique), Site d'initiation de la transcription, Séquence nucléotidique, Transcription génétique, Virus du SRAS (génétique).
- MESH :
English descriptors
- KwdEn :
- Animals, Base Sequence, Chlorocebus aethiops, Cricetinae, Genome, Viral, Molecular Sequence Data, Open Reading Frames, RNA, Messenger (genetics), RNA, Viral (biosynthesis), RNA, Viral (genetics), SARS Virus (genetics), Templates, Genetic, Transcription Initiation Site, Transcription, Genetic, Vero Cells.
- MESH :
- chemical , biosynthesis : RNA, Viral.
- chemical , genetics : RNA, Messenger, RNA, Viral.
- genetics : SARS Virus.
- Animals, Base Sequence, Chlorocebus aethiops, Cricetinae, Genome, Viral, Molecular Sequence Data, Open Reading Frames, Templates, Genetic, Transcription Initiation Site, Transcription, Genetic, Vero Cells.
Abstract
The expression of the genomic information of severe acute respiratory syndrome coronavirus (SARS CoV) involves synthesis of a nested set of subgenomic RNAs (sgRNAs) by discontinuous transcription. In SARS CoV-infected cells, 10 sgRNAs, including 2 novel ones, were identified, which were predicted to be functional in the expression of 12 open reading frames located in the 3′ one-third of the genome. Surprisingly, one new sgRNA could lead to production of a truncated spike protein. Sequence analysis of the leader-body fusion sites of each sgRNA showed that the junction sequences and the corresponding transcription-regulatory sequence (TRS) are unique for each species of sgRNA and are consistent after virus passages. For the two novel sgRNAs, each used a variant of the TRS that has one nucleotide mismatch in the conserved hexanucleotide core (ACGAAC) in the TRS. Coexistence of both plus and minus strands of SARS CoV sgRNAs and evidence for derivation of the sgRNA core sequence from the body core sequence favor the model of discontinuous transcription during minus-strand synthesis. Moreover, one rare species of sgRNA has the junction sequence AAA, indicating that its transcription could result from a noncanonical transcription signal. Taken together, these results provide more insight into the molecular mechanisms of genome expression and subgenomic transcription of SARS CoV.
Url:
DOI: 10.1128/JVI.79.9.5288-5295.2005
PubMed: 15827143
PubMed Central: 1082772
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sort="Pan, Ji An" uniqKey="Pan J" first="Ji'An" last="Pan">Ji'An Pan</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name></author><author><name sortKey="Yang, Yalin" sort="Yang, Yalin" uniqKey="Yang Y" first="Yalin" last="Yang">Yalin Yang</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of 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type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Li, Zhaoyang" sort="Li, Zhaoyang" uniqKey="Li Z" first="Zhaoyang" last="Li">Zhaoyang Li</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Zhu, Ying" sort="Zhu, Ying" uniqKey="Zhu Y" first="Ying" last="Zhu">Ying Zhu</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Tien, Po" sort="Tien, Po" uniqKey="Tien P" first="Po" last="Tien">Po Tien</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life 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Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Pan, Ji An" sort="Pan, Ji An" uniqKey="Pan J" first="Ji'An" last="Pan">Ji'An Pan</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name></author><author><name sortKey="Yang, Yalin" sort="Yang, Yalin" uniqKey="Yang Y" first="Yalin" last="Yang">Yalin Yang</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Peng, Yu" sort="Peng, Yu" uniqKey="Peng Y" first="Yu" last="Peng">Yu Peng</name></author><author><name sortKey="Wu, Ying" sort="Wu, Ying" uniqKey="Wu Y" first="Ying" last="Wu">Ying Wu</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Li, Zhaoyang" sort="Li, Zhaoyang" uniqKey="Li Z" first="Zhaoyang" last="Li">Zhaoyang Li</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Zhu, Ying" sort="Zhu, Ying" uniqKey="Zhu Y" first="Ying" last="Zhu">Ying Zhu</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Tien, Po" sort="Tien, Po" uniqKey="Tien P" first="Po" last="Tien">Po Tien</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Guo, Deyin" sort="Guo, Deyin" uniqKey="Guo D" first="Deyin" last="Guo">Deyin Guo</name><affiliation wicri:level="4"><nlm:aff id="aff0"> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Modern Virology Research Centre and National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Chlorocebus aethiops</term><term>Cricetinae</term><term>Genome, Viral</term><term>Molecular Sequence Data</term><term>Open Reading Frames</term><term>RNA, Messenger (genetics)</term><term>RNA, Viral (biosynthesis)</term><term>RNA, Viral (genetics)</term><term>SARS Virus (genetics)</term><term>Templates, Genetic</term><term>Transcription Initiation Site</term><term>Transcription, Genetic</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN viral (biosynthèse)</term><term>ARN viral (génétique)</term><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Cellules Vero</term><term>Cricetinae</term><term>Données de séquences moléculaires</term><term>Génome viral</term><term>Matrices (génétique)</term><term>Site d'initiation de la transcription</term><term>Séquence nucléotidique</term><term>Transcription génétique</term><term>Virus du SRAS (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>ARN viral</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Chlorocebus aethiops</term><term>Cricetinae</term><term>Genome, Viral</term><term>Molecular Sequence Data</term><term>Open Reading Frames</term><term>Templates, Genetic</term><term>Transcription Initiation Site</term><term>Transcription, Genetic</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Cellules Vero</term><term>Cricetinae</term><term>Données de séquences moléculaires</term><term>Génome viral</term><term>Matrices (génétique)</term><term>Site d'initiation de la transcription</term><term>Séquence nucléotidique</term><term>Transcription génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The expression of the genomic information of severe acute respiratory syndrome coronavirus (SARS CoV) involves synthesis of a nested set of subgenomic RNAs (sgRNAs) by discontinuous transcription. In SARS CoV-infected cells, 10 sgRNAs, including 2 novel ones, were identified, which were predicted to be functional in the expression of 12 open reading frames located in the 3′ one-third of the genome. Surprisingly, one new sgRNA could lead to production of a truncated spike protein. Sequence analysis of the leader-body fusion sites of each sgRNA showed that the junction sequences and the corresponding transcription-regulatory sequence (TRS) are unique for each species of sgRNA and are consistent after virus passages. For the two novel sgRNAs, each used a variant of the TRS that has one nucleotide mismatch in the conserved hexanucleotide core (ACGAAC) in the TRS. Coexistence of both plus and minus strands of SARS CoV sgRNAs and evidence for derivation of the sgRNA core sequence from the body core sequence favor the model of discontinuous transcription during minus-strand synthesis. Moreover, one rare species of sgRNA has the junction sequence AAA, indicating that its transcription could result from a noncanonical transcription signal. Taken together, these results provide more insight into the molecular mechanisms of genome expression and subgenomic transcription of SARS CoV.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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