An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins : Structures, functions and drug development : SARS-CoV: A scénario of modern drug design
Identifieur interne : 004716 ( Main/Merge ); précédent : 004715; suivant : 004717An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins : Structures, functions and drug development : SARS-CoV: A scénario of modern drug design
Auteurs : SHUAI CHEN [République populaire de Chine] ; HAIBIN LUO [République populaire de Chine] ; LILI CHEN [République populaire de Chine] ; JING CHEN [République populaire de Chine] ; JIANHUA SHEN [République populaire de Chine] ; WEILIANG ZHU [République populaire de Chine] ; KAIXIAN CHEN [République populaire de Chine] ; XU SHEN [République populaire de Chine] ; HUALIANG JIANG [République populaire de Chine]Source :
- Current pharmaceutical design [ 1381-6128 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Médicament.
English descriptors
- KwdEn :
Abstract
A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-CoV) has been recently identified as the etiological agent responsible for the infectious SARS disease. Based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of SARS-CoV, as well as the detailed characters of the major proteins involved in SARS-CoV life cycle. In this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of SARS-CoV associated key proteins. The progress focused on the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
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Pascal:07-0053590Le document en format XML
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<front><div type="abstract" xml:lang="en">A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-CoV) has been recently identified as the etiological agent responsible for the infectious SARS disease. Based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of SARS-CoV, as well as the detailed characters of the major proteins involved in SARS-CoV life cycle. In this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of SARS-CoV associated key proteins. The progress focused on the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.</div>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Shuai Chen" sort="Shuai Chen" uniqKey="Shuai Chen" last="Shuai Chen">SHUAI CHEN</name>
</noRegion>
<name sortKey="Haibin Luo" sort="Haibin Luo" uniqKey="Haibin Luo" last="Haibin Luo">HAIBIN LUO</name>
<name sortKey="Hualiang Jiang" sort="Hualiang Jiang" uniqKey="Hualiang Jiang" last="Hualiang Jiang">HUALIANG JIANG</name>
<name sortKey="Hualiang Jiang" sort="Hualiang Jiang" uniqKey="Hualiang Jiang" last="Hualiang Jiang">HUALIANG JIANG</name>
<name sortKey="Jianhua Shen" sort="Jianhua Shen" uniqKey="Jianhua Shen" last="Jianhua Shen">JIANHUA SHEN</name>
<name sortKey="Jing Chen" sort="Jing Chen" uniqKey="Jing Chen" last="Jing Chen">JING CHEN</name>
<name sortKey="Kaixian Chen" sort="Kaixian Chen" uniqKey="Kaixian Chen" last="Kaixian Chen">KAIXIAN CHEN</name>
<name sortKey="Lili Chen" sort="Lili Chen" uniqKey="Lili Chen" last="Lili Chen">LILI CHEN</name>
<name sortKey="Weiliang Zhu" sort="Weiliang Zhu" uniqKey="Weiliang Zhu" last="Weiliang Zhu">WEILIANG ZHU</name>
<name sortKey="Xu Shen" sort="Xu Shen" uniqKey="Xu Shen" last="Xu Shen">XU SHEN</name>
<name sortKey="Xu Shen" sort="Xu Shen" uniqKey="Xu Shen" last="Xu Shen">XU SHEN</name>
</country>
</tree>
</affiliations>
</record>
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