SrasV1, PascalFrancis, Checkpoint, bibRecord, 000515

An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins : Structures, functions and drug development : SARS-CoV: A scénario of modern drug design

Identifieur interne : 000515 ( PascalFrancis/Checkpoint ); précédent : 000514; suivant : 000516

An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins : Structures, functions and drug development : SARS-CoV: A scénario of modern drug design

Auteurs : SHUAI CHEN [République populaire de Chine] ; HAIBIN LUO [République populaire de Chine] ; LILI CHEN [République populaire de Chine] ; JING CHEN [République populaire de Chine] ; JIANHUA SHEN [République populaire de Chine] ; WEILIANG ZHU [République populaire de Chine] ; KAIXIAN CHEN [République populaire de Chine] ; XU SHEN [République populaire de Chine] ; HUALIANG JIANG [République populaire de Chine]

Source :

Current pharmaceutical design [ 1381-6128 ] ; 2006.

RBID : Pascal:07-0053590

Descripteurs français

Pascal (Inist)
- Coronavirus, Syndrome respiratoire aigu sévère, Génome, Protéine, Fonction structure, Recherche développement, Médicament, Atypique, Pneumonie, Structure moléculaire, Inhibiteur, Criblage, Article synthèse.
Wicri :
- topic : Médicament.

English descriptors

KwdEn :
- Atypical, Coronavirus, Drug, Genome, Inhibitor, Molecular structure, Pneumonia, Protein, Research and development, Review, Screening, Severe acute respiratory syndrome, Structure function.

Abstract

A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-CoV) has been recently identified as the etiological agent responsible for the infectious SARS disease. Based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of SARS-CoV, as well as the detailed characters of the major proteins involved in SARS-CoV life cycle. In this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of SARS-CoV associated key proteins. The progress focused on the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.

Affiliations:

République populaire de Chine

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Le document en format XML

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<front><div type="abstract" xml:lang="en">A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-CoV) has been recently identified as the etiological agent responsible for the infectious SARS disease. Based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of SARS-CoV, as well as the detailed characters of the major proteins involved in SARS-CoV life cycle. In this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of SARS-CoV associated key proteins. The progress focused on the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1381-6128</s0>
</fA01>
<fA03 i2="1"><s0>Curr. pharm. des.</s0>
</fA03>
<fA05><s2>12</s2>
</fA05>
<fA06><s2>35</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins : Structures, functions and drug development : SARS-CoV: A scénario of modern drug design</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>SHUAI CHEN</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>HAIBIN LUO</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>LILI CHEN</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>JING CHEN</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>JIANHUA SHEN</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>WEILIANG ZHU</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KAIXIAN CHEN</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>XU SHEN</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>HUALIANG JIANG</s1>
</fA11>
<fA14 i1="01"><s1>Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences</s1>
<s2>Shanghai 201 203</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>School of Pharmacy, East China University of Science and Technology</s1>
<s2>Shanghai 200237</s2>
<s3>CHN</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA20><s1>4539-4553</s1>
</fA20>
<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>26320</s2>
<s5>354000145201350010</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>106 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0053590</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Current pharmaceutical design</s0>
</fA64>
<fA66 i1="01"><s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-CoV) has been recently identified as the etiological agent responsible for the infectious SARS disease. Based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of SARS-CoV, as well as the detailed characters of the major proteins involved in SARS-CoV life cycle. In this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of SARS-CoV associated key proteins. The progress focused on the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B02S05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Génome</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Genome</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Genoma</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Protéine</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Protein</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Proteína</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Fonction structure</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Structure function</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Función estructura</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Recherche développement</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Research and development</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Investigación desarrollo</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Médicament</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Drug</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Medicamento</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Atypique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Atypical</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Atípico</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Pneumonie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Pneumonia</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Neumonía</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Structure moléculaire</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Molecular structure</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Estructura molecular</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Inhibiteur</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Inhibitor</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Inhibidor</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Criblage</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Screening</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Cernido</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Article synthèse</s0>
<s5>16</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Review</s0>
<s5>16</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Artículo síntesis</s0>
<s5>16</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>036</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Shuai Chen" sort="Shuai Chen" uniqKey="Shuai Chen" last="Shuai Chen">SHUAI CHEN</name>
</noRegion>
<name sortKey="Haibin Luo" sort="Haibin Luo" uniqKey="Haibin Luo" last="Haibin Luo">HAIBIN LUO</name>
<name sortKey="Hualiang Jiang" sort="Hualiang Jiang" uniqKey="Hualiang Jiang" last="Hualiang Jiang">HUALIANG JIANG</name>
<name sortKey="Hualiang Jiang" sort="Hualiang Jiang" uniqKey="Hualiang Jiang" last="Hualiang Jiang">HUALIANG JIANG</name>
<name sortKey="Jianhua Shen" sort="Jianhua Shen" uniqKey="Jianhua Shen" last="Jianhua Shen">JIANHUA SHEN</name>
<name sortKey="Jing Chen" sort="Jing Chen" uniqKey="Jing Chen" last="Jing Chen">JING CHEN</name>
<name sortKey="Kaixian Chen" sort="Kaixian Chen" uniqKey="Kaixian Chen" last="Kaixian Chen">KAIXIAN CHEN</name>
<name sortKey="Lili Chen" sort="Lili Chen" uniqKey="Lili Chen" last="Lili Chen">LILI CHEN</name>
<name sortKey="Weiliang Zhu" sort="Weiliang Zhu" uniqKey="Weiliang Zhu" last="Weiliang Zhu">WEILIANG ZHU</name>
<name sortKey="Xu Shen" sort="Xu Shen" uniqKey="Xu Shen" last="Xu Shen">XU SHEN</name>
<name sortKey="Xu Shen" sort="Xu Shen" uniqKey="Xu Shen" last="Xu Shen">XU SHEN</name>
</country>
</tree>
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An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins : Structures, functions and drug development : SARS-CoV: A scénario of modern drug design

An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins : Structures, functions and drug development : SARS-CoV: A scénario of modern drug design

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