SrasV1, Main, Merge, bibRecord, 003052

The role of programmed-1 ribosomal frameshifting in coronavirus propagation

Identifieur interne : 003052 ( Main/Merge ); précédent : 003051; suivant : 003053

The role of programmed-1 ribosomal frameshifting in coronavirus propagation

Auteurs : Ewan P. Plant [États-Unis] ; Jonathan D. Dinman [États-Unis]

Source :

Frontiers in bioscience : a journal and virtual library [ 1093-9946 ] ; 2008.

RBID : PMC:2435135

Descripteurs français

KwdFr :
- Cadres ouverts de lecture, Coronavirus (croissance et développement), Coronavirus (génétique), Coronavirus (physiologie), Décalage ribosomique du cadre de lecture, Humains, Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (génétique), Virus du SRAS (physiologie).
MESH :
- croissance et développement : Coronavirus.
- génétique : Coronavirus, Virus du SRAS.
- physiologie : Coronavirus, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Cadres ouverts de lecture, Décalage ribosomique du cadre de lecture, Humains.

English descriptors

KwdEn :
- Coronavirus (genetics), Coronavirus (growth & development), Coronavirus (physiology), Frameshifting, Ribosomal, Humans, Open Reading Frames, SARS Virus (genetics), SARS Virus (physiology), Severe Acute Respiratory Syndrome (virology).
MESH :
- genetics : Coronavirus, SARS Virus.
- growth & development : Coronavirus.
- physiology : Coronavirus, SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Frameshifting, Ribosomal, Humans, Open Reading Frames.

Abstract

Coronaviruses have the potential to cause significant economic, agricultural and health problems. The severe acute respiratory syndrome (SARS) associated coronavirus outbreak in late 2002, early 2003 called attention to the potential damage that coronaviruses could cause in the human population. The ensuing research has enlightened many to the molecular biology of coronaviruses. A programmed -1 ribosomal frameshift is required by coronaviruses for the production of the RNA dependent RNA polymerase which in turn is essential for viral replication. The frameshifting signal encoded in the viral genome has additional features that are not essential for frameshifting. Elucidation of the differences between coronavirus frameshift signals and signals from other viruses may help our understanding of these features. Here we summarize current knowledge and add additional insight regarding the function of the programmed -1 ribosomal frameshift signal in the coronavirus lifecycle.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435135

PubMed: 18508552
PubMed Central: 2435135

Links to Exploration step

PMC:2435135

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of programmed-1 ribosomal frameshifting in coronavirus propagation</title>
<author><name sortKey="Plant, Ewan P" sort="Plant, Ewan P" uniqKey="Plant E" first="Ewan P." last="Plant">Ewan P. Plant</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dinman, Jonathan D" sort="Dinman, Jonathan D" uniqKey="Dinman J" first="Jonathan D." last="Dinman">Jonathan D. Dinman</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18508552</idno>
<idno type="pmc">2435135</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435135</idno>
<idno type="RBID">PMC:2435135</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000C16</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C16</idno>
<idno type="wicri:Area/Pmc/Curation">000C16</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C16</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D62</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D62</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18508552</idno>
<idno type="wicri:Area/PubMed/Corpus">001B30</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B30</idno>
<idno type="wicri:Area/PubMed/Curation">001B30</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B30</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001987</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001987</idno>
<idno type="wicri:Area/Ncbi/Merge">001C70</idno>
<idno type="wicri:Area/Ncbi/Curation">001C70</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C70</idno>
<idno type="wicri:doubleKey">1093-9946:2008:Plant E:the:role:of</idno>
<idno type="wicri:Area/Main/Merge">003052</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The role of programmed-1 ribosomal frameshifting in coronavirus propagation</title>
<author><name sortKey="Plant, Ewan P" sort="Plant, Ewan P" uniqKey="Plant E" first="Ewan P." last="Plant">Ewan P. Plant</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dinman, Jonathan D" sort="Dinman, Jonathan D" uniqKey="Dinman J" first="Jonathan D." last="Dinman">Jonathan D. Dinman</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in bioscience : a journal and virtual library</title>
<idno type="ISSN">1093-9946</idno>
<idno type="eISSN">1093-4715</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus (genetics)</term>
<term>Coronavirus (growth & development)</term>
<term>Coronavirus (physiology)</term>
<term>Frameshifting, Ribosomal</term>
<term>Humans</term>
<term>Open Reading Frames</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (physiology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cadres ouverts de lecture</term>
<term>Coronavirus (croissance et développement)</term>
<term>Coronavirus (génétique)</term>
<term>Coronavirus (physiologie)</term>
<term>Décalage ribosomique du cadre de lecture</term>
<term>Humains</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Frameshifting, Ribosomal</term>
<term>Humans</term>
<term>Open Reading Frames</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cadres ouverts de lecture</term>
<term>Décalage ribosomique du cadre de lecture</term>
<term>Humains</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Coronaviruses have the potential to cause significant economic, agricultural and health problems. The severe acute respiratory syndrome (SARS) associated coronavirus outbreak in late 2002, early 2003 called attention to the potential damage that coronaviruses could cause in the human population. The ensuing research has enlightened many to the molecular biology of coronaviruses. A programmed -1 ribosomal frameshift is required by coronaviruses for the production of the RNA dependent RNA polymerase which in turn is essential for viral replication. The frameshifting signal encoded in the viral genome has additional features that are not essential for frameshifting. Elucidation of the differences between coronavirus frameshift signals and signals from other viruses may help our understanding of these features. Here we summarize current knowledge and add additional insight regarding the function of the programmed -1 ribosomal frameshift signal in the coronavirus lifecycle.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003052 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003052 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:2435135
   |texte=   The role of programmed-1 ribosomal frameshifting in coronavirus propagation
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:18508552" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

The role of programmed-1 ribosomal frameshifting in coronavirus propagation

The role of programmed-1 ribosomal frameshifting in coronavirus propagation

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.