The role of programmed-1 ribosomal frameshifting in coronavirus propagation
Identifieur interne : 000C16 ( Pmc/Curation ); précédent : 000C15; suivant : 000C17The role of programmed-1 ribosomal frameshifting in coronavirus propagation
Auteurs : Ewan P. Plant [États-Unis] ; Jonathan D. Dinman [États-Unis]Source :
- Frontiers in bioscience : a journal and virtual library [ 1093-9946 ] ; 2008.
Abstract
Coronaviruses have the potential to cause significant economic, agricultural and health problems. The severe acute respiratory syndrome (SARS) associated coronavirus outbreak in late 2002, early 2003 called attention to the potential damage that coronaviruses could cause in the human population. The ensuing research has enlightened many to the molecular biology of coronaviruses. A programmed -1 ribosomal frameshift is required by coronaviruses for the production of the RNA dependent RNA polymerase which in turn is essential for viral replication. The frameshifting signal encoded in the viral genome has additional features that are not essential for frameshifting. Elucidation of the differences between coronavirus frameshift signals and signals from other viruses may help our understanding of these features. Here we summarize current knowledge and add additional insight regarding the function of the programmed -1 ribosomal frameshift signal in the coronavirus lifecycle.
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PubMed: 18508552
PubMed Central: 2435135
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9709506</journal-id><journal-id journal-id-type="pubmed-jr-id">29838</journal-id><journal-id journal-id-type="nlm-ta">Front Biosci</journal-id><journal-title>Frontiers in bioscience : a journal and virtual library</journal-title><issn pub-type="ppub">1093-9946</issn><issn pub-type="epub">1093-4715</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18508552</article-id><article-id pub-id-type="pmc">2435135</article-id><article-id pub-id-type="manuscript">NIHMS54449</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The role of programmed-1 ribosomal frameshifting in coronavirus propagation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Plant</surname><given-names>Ewan P.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Dinman</surname><given-names>Jonathan D.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib></contrib-group><aff id="A1"><label>1</label> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland</aff><aff id="A2"><label>2</label> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland</aff><author-notes><corresp id="FN1">Send correspondence to: Ewan Plant, CBER, FDA, HFM-310, 8800 Rockville Pike, Bethesda MD 20892, Tel: 301-827-1954, Fax: 301-480-4757, E-mail: <email>Ewan.Plant@FDA.hhs.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>6</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>1</day><month>5</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>6</month><year>2008</year></pub-date><volume>13</volume><fpage>4873</fpage><lpage>4881</lpage><abstract><p id="P1">Coronaviruses have the potential to cause significant economic, agricultural and health problems. The severe acute respiratory syndrome (SARS) associated coronavirus outbreak in late 2002, early 2003 called attention to the potential damage that coronaviruses could cause in the human population. The ensuing research has enlightened many to the molecular biology of coronaviruses. A programmed -1 ribosomal frameshift is required by coronaviruses for the production of the RNA dependent RNA polymerase which in turn is essential for viral replication. The frameshifting signal encoded in the viral genome has additional features that are not essential for frameshifting. Elucidation of the differences between coronavirus frameshift signals and signals from other viruses may help our understanding of these features. Here we summarize current knowledge and add additional insight regarding the function of the programmed -1 ribosomal frameshift signal in the coronavirus lifecycle.</p></abstract><kwd-group><kwd>Coronavirus</kwd><kwd>SARS</kwd><kwd>Frameshifting</kwd><kwd>Review</kwd></kwd-group><contract-num rid="AI1">R01 AI064307-02</contract-num><contract-num rid="AI1">R01 AI064307-01A2</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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