The role of programmed-1 ribosomal frameshifting in coronavirus propagation
Identifieur interne : 001C70 ( Ncbi/Checkpoint ); précédent : 001C69; suivant : 001C71The role of programmed-1 ribosomal frameshifting in coronavirus propagation
Auteurs : Ewan P. Plant [États-Unis] ; Jonathan D. Dinman [États-Unis]Source :
- Frontiers in bioscience : a journal and virtual library [ 1093-9946 ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
- croissance et développement : Coronavirus.
- génétique : Coronavirus, Virus du SRAS.
- physiologie : Coronavirus, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Cadres ouverts de lecture, Décalage ribosomique du cadre de lecture, Humains.
English descriptors
- KwdEn :
- MESH :
- genetics : Coronavirus, SARS Virus.
- growth & development : Coronavirus.
- physiology : Coronavirus, SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Frameshifting, Ribosomal, Humans, Open Reading Frames.
Abstract
Coronaviruses have the potential to cause significant economic, agricultural and health problems. The severe acute respiratory syndrome (SARS) associated coronavirus outbreak in late 2002, early 2003 called attention to the potential damage that coronaviruses could cause in the human population. The ensuing research has enlightened many to the molecular biology of coronaviruses. A programmed -1 ribosomal frameshift is required by coronaviruses for the production of the RNA dependent RNA polymerase which in turn is essential for viral replication. The frameshifting signal encoded in the viral genome has additional features that are not essential for frameshifting. Elucidation of the differences between coronavirus frameshift signals and signals from other viruses may help our understanding of these features. Here we summarize current knowledge and add additional insight regarding the function of the programmed -1 ribosomal frameshift signal in the coronavirus lifecycle.
Url:
PubMed: 18508552
PubMed Central: 2435135
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000C16
- to stream Pmc, to step Curation: 000C16
- to stream Pmc, to step Checkpoint: 000D62
- to stream PubMed, to step Corpus: 001B30
- to stream PubMed, to step Curation: 001B30
- to stream PubMed, to step Checkpoint: 001987
- to stream Ncbi, to step Merge: 001C70
- to stream Ncbi, to step Curation: 001C70
Links to Exploration step
PMC:2435135Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of programmed-1 ribosomal frameshifting in coronavirus propagation</title>
<author><name sortKey="Plant, Ewan P" sort="Plant, Ewan P" uniqKey="Plant E" first="Ewan P." last="Plant">Ewan P. Plant</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dinman, Jonathan D" sort="Dinman, Jonathan D" uniqKey="Dinman J" first="Jonathan D." last="Dinman">Jonathan D. Dinman</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18508552</idno>
<idno type="pmc">2435135</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435135</idno>
<idno type="RBID">PMC:2435135</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000C16</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C16</idno>
<idno type="wicri:Area/Pmc/Curation">000C16</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C16</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D62</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D62</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18508552</idno>
<idno type="wicri:Area/PubMed/Corpus">001B30</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B30</idno>
<idno type="wicri:Area/PubMed/Curation">001B30</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B30</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001987</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001987</idno>
<idno type="wicri:Area/Ncbi/Merge">001C70</idno>
<idno type="wicri:Area/Ncbi/Curation">001C70</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C70</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The role of programmed-1 ribosomal frameshifting in coronavirus propagation</title>
<author><name sortKey="Plant, Ewan P" sort="Plant, Ewan P" uniqKey="Plant E" first="Ewan P." last="Plant">Ewan P. Plant</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dinman, Jonathan D" sort="Dinman, Jonathan D" uniqKey="Dinman J" first="Jonathan D." last="Dinman">Jonathan D. Dinman</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea> Department of Cell Biology and Molecular Genetics, University of Maryland, College Park</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in bioscience : a journal and virtual library</title>
<idno type="ISSN">1093-9946</idno>
<idno type="eISSN">1093-4715</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus (genetics)</term>
<term>Coronavirus (growth & development)</term>
<term>Coronavirus (physiology)</term>
<term>Frameshifting, Ribosomal</term>
<term>Humans</term>
<term>Open Reading Frames</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (physiology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cadres ouverts de lecture</term>
<term>Coronavirus (croissance et développement)</term>
<term>Coronavirus (génétique)</term>
<term>Coronavirus (physiologie)</term>
<term>Décalage ribosomique du cadre de lecture</term>
<term>Humains</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Frameshifting, Ribosomal</term>
<term>Humans</term>
<term>Open Reading Frames</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cadres ouverts de lecture</term>
<term>Décalage ribosomique du cadre de lecture</term>
<term>Humains</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Coronaviruses have the potential to cause significant economic, agricultural and health problems. The severe acute respiratory syndrome (SARS) associated coronavirus outbreak in late 2002, early 2003 called attention to the potential damage that coronaviruses could cause in the human population. The ensuing research has enlightened many to the molecular biology of coronaviruses. A programmed -1 ribosomal frameshift is required by coronaviruses for the production of the RNA dependent RNA polymerase which in turn is essential for viral replication. The frameshifting signal encoded in the viral genome has additional features that are not essential for frameshifting. Elucidation of the differences between coronavirus frameshift signals and signals from other viruses may help our understanding of these features. Here we summarize current knowledge and add additional insight regarding the function of the programmed -1 ribosomal frameshift signal in the coronavirus lifecycle.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Plant, Ewan P" sort="Plant, Ewan P" uniqKey="Plant E" first="Ewan P." last="Plant">Ewan P. Plant</name>
</region>
<name sortKey="Dinman, Jonathan D" sort="Dinman, Jonathan D" uniqKey="Dinman J" first="Jonathan D." last="Dinman">Jonathan D. Dinman</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C70 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001C70 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:2435135 |texte= The role of programmed-1 ribosomal frameshifting in coronavirus propagation }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:18508552" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |