Oral immunization of mice with recombinant Lactococcus lactis expressing porcine transmissible gastroenteritis virus spike glycoprotein.
Identifieur interne : 002A62 ( Main/Exploration ); précédent : 002A61; suivant : 002A63Oral immunization of mice with recombinant Lactococcus lactis expressing porcine transmissible gastroenteritis virus spike glycoprotein.
Auteurs : Lijie Tang [République populaire de Chine] ; Yijing LiSource :
- Virus genes [ 1572-994X ] ; 2009.
Descripteurs français
- KwdFr :
- Administration par voie orale, Animaux, Anticorps antiviraux (immunologie), Anticorps neutralisants (immunologie), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Lactococcus lactis (génétique), Muqueuse intestinale (immunologie), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Protéines recombinantes (génétique), Protéines recombinantes (immunologie), Souris, Souris de lignée BALB C, Sérum (immunologie), Test ELISA, Tests de neutralisation, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Vecteurs de médicaments, Vecteurs génétiques, Virus de la gastroentérite transmissible (génétique), Virus de la gastroentérite transmissible (immunologie).
- MESH :
- administration et posologie : Vaccins antiviraux.
- génétique : Glycoprotéines membranaires, Lactococcus lactis, Protéines de l'enveloppe virale, Protéines recombinantes, Vaccins antiviraux, Vaccins synthétiques, Virus de la gastroentérite transmissible.
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Glycoprotéines membranaires, Muqueuse intestinale, Protéines de l'enveloppe virale, Protéines recombinantes, Sérum, Vaccins antiviraux, Vaccins synthétiques, Virus de la gastroentérite transmissible.
- Administration par voie orale, Animaux, Glycoprotéine de spicule des coronavirus, Souris, Souris de lignée BALB C, Test ELISA, Tests de neutralisation, Vecteurs de médicaments, Vecteurs génétiques.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Drug Carriers, Enzyme-Linked Immunosorbent Assay, Genetic Vectors, Intestinal Mucosa (immunology), Lactococcus lactis (genetics), Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Mice, Mice, Inbred BALB C, Neutralization Tests, Recombinant Proteins (genetics), Recombinant Proteins (immunology), Serum (immunology), Spike Glycoprotein, Coronavirus, Transmissible gastroenteritis virus (genetics), Transmissible gastroenteritis virus (immunology), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Viral Vaccines.
- chemical , genetics : Membrane Glycoproteins, Recombinant Proteins, Vaccines, Synthetic, Viral Envelope Proteins, Viral Vaccines.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Membrane Glycoproteins, Recombinant Proteins, Vaccines, Synthetic, Viral Envelope Proteins, Viral Vaccines.
- genetics : Lactococcus lactis, Transmissible gastroenteritis virus.
- immunology : Intestinal Mucosa, Serum, Transmissible gastroenteritis virus.
- Administration, Oral, Animals, Drug Carriers, Enzyme-Linked Immunosorbent Assay, Genetic Vectors, Mice, Mice, Inbred BALB C, Neutralization Tests, Spike Glycoprotein, Coronavirus.
Abstract
Lactococcus lactis NZ9000 was selected as an antigen delivery vehicle for mucosal immunization against porcine transmissible gastroenteritis virus (TGEV) infection. An approximately 70 kDa fragment of the N-terminal globular domain of the spike (S) protein (SN protein) from the coronavirus TGEV was used as the transmissible gastroenteritis virus antigen model. Recombinant L. lactis, expressing the SN protein, was constructed with the pNZ8112 plasmid. Expression and localization of the transcribed SN protein from the recombinant LNZ9000- rTGEV-SN were detected via SDS-PAGE, Western blot, and immunofluorescence. BALB/c mice, orally immunized with LNZ9000-rTGEV-SN, produced local mucosal immune responses against TGEV. The induced antibodies demonstrated neutralizing effects on TGEV infection. These data indicated that the recombinant L. lactis could be a valuable tool in the development of future vaccines against TGEV.
DOI: 10.1007/s11262-009-0390-x
PubMed: 19629668
Affiliations:
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Le document en format XML
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<series><title level="j">Virus genes</title>
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<term>Animals</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Drug Carriers</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Genetic Vectors</term>
<term>Intestinal Mucosa (immunology)</term>
<term>Lactococcus lactis (genetics)</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
<term>Recombinant Proteins (genetics)</term>
<term>Recombinant Proteins (immunology)</term>
<term>Serum (immunology)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Transmissible gastroenteritis virus (genetics)</term>
<term>Transmissible gastroenteritis virus (immunology)</term>
<term>Vaccines, Synthetic (genetics)</term>
<term>Vaccines, Synthetic (immunology)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Envelope Proteins (immunology)</term>
<term>Viral Vaccines (administration & dosage)</term>
<term>Viral Vaccines (genetics)</term>
<term>Viral Vaccines (immunology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term>
<term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Glycoprotéines membranaires (immunologie)</term>
<term>Lactococcus lactis (génétique)</term>
<term>Muqueuse intestinale (immunologie)</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Protéines recombinantes (génétique)</term>
<term>Protéines recombinantes (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sérum (immunologie)</term>
<term>Test ELISA</term>
<term>Tests de neutralisation</term>
<term>Vaccins antiviraux (administration et posologie)</term>
<term>Vaccins antiviraux (génétique)</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins synthétiques (génétique)</term>
<term>Vaccins synthétiques (immunologie)</term>
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<term>Vecteurs génétiques</term>
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<term>Virus de la gastroentérite transmissible (immunologie)</term>
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<term>Recombinant Proteins</term>
<term>Vaccines, Synthetic</term>
<term>Viral Envelope Proteins</term>
<term>Viral Vaccines</term>
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<term>Antibodies, Viral</term>
<term>Membrane Glycoproteins</term>
<term>Recombinant Proteins</term>
<term>Vaccines, Synthetic</term>
<term>Viral Envelope Proteins</term>
<term>Viral Vaccines</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lactococcus lactis</term>
<term>Transmissible gastroenteritis virus</term>
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<term>Lactococcus lactis</term>
<term>Protéines de l'enveloppe virale</term>
<term>Protéines recombinantes</term>
<term>Vaccins antiviraux</term>
<term>Vaccins synthétiques</term>
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<term>Anticorps neutralisants</term>
<term>Glycoprotéines membranaires</term>
<term>Muqueuse intestinale</term>
<term>Protéines de l'enveloppe virale</term>
<term>Protéines recombinantes</term>
<term>Sérum</term>
<term>Vaccins antiviraux</term>
<term>Vaccins synthétiques</term>
<term>Virus de la gastroentérite transmissible</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Intestinal Mucosa</term>
<term>Serum</term>
<term>Transmissible gastroenteritis virus</term>
</keywords>
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<term>Animals</term>
<term>Drug Carriers</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Genetic Vectors</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
<term>Spike Glycoprotein, Coronavirus</term>
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<term>Animaux</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Test ELISA</term>
<term>Tests de neutralisation</term>
<term>Vecteurs de médicaments</term>
<term>Vecteurs génétiques</term>
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<front><div type="abstract" xml:lang="en">Lactococcus lactis NZ9000 was selected as an antigen delivery vehicle for mucosal immunization against porcine transmissible gastroenteritis virus (TGEV) infection. An approximately 70 kDa fragment of the N-terminal globular domain of the spike (S) protein (SN protein) from the coronavirus TGEV was used as the transmissible gastroenteritis virus antigen model. Recombinant L. lactis, expressing the SN protein, was constructed with the pNZ8112 plasmid. Expression and localization of the transcribed SN protein from the recombinant LNZ9000- rTGEV-SN were detected via SDS-PAGE, Western blot, and immunofluorescence. BALB/c mice, orally immunized with LNZ9000-rTGEV-SN, produced local mucosal immune responses against TGEV. The induced antibodies demonstrated neutralizing effects on TGEV infection. These data indicated that the recombinant L. lactis could be a valuable tool in the development of future vaccines against TGEV.</div>
</front>
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<country name="République populaire de Chine"><noRegion><name sortKey="Tang, Lijie" sort="Tang, Lijie" uniqKey="Tang L" first="Lijie" last="Tang">Lijie Tang</name>
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