Mosaic evolution of the severe acute respiratory syndrome coronavirus
Identifieur interne : 005B04 ( Main/Exploration ); précédent : 005B03; suivant : 005B05Mosaic evolution of the severe acute respiratory syndrome coronavirus
Auteurs : John Stavrinides [Canada] ; David S. Guttman [Canada]Source :
- Journal of virology [ 0022-538X ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Biologie informatique (), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Humains, Phylogénie, Polyprotéines (génétique), Protéines de l'enveloppe virale (génétique), Protéines de la matrice virale (génétique), Protéines nucléocapside (génétique), Protéines virales (génétique), Recombinaison génétique, Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (génétique), Évolution biologique.
- MESH :
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Biological Evolution, Computational Biology (methods), Coronavirus, Evolution, Humans, Membrane Glycoproteins (genetics), Microbiology, Nucleocapsid Proteins (genetics), Phylogeny, Polyproteins (genetics), Recombination, Genetic, SARS Virus (genetics), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (genetics), Viral Matrix Proteins (genetics), Viral Proteins (genetics), Virology.
- MESH :
- chemical , genetics : Membrane Glycoproteins, Nucleocapsid Proteins, Polyproteins, Viral Envelope Proteins, Viral Matrix Proteins, Viral Proteins.
- genetics : SARS Virus.
- methods : Computational Biology.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Biological Evolution, Humans, Phylogeny, Recombination, Genetic, Spike Glycoprotein, Coronavirus.
Abstract
Severe acute respiratory syndrome (SARS) is a deadly form of pneumonia caused by a novel coronavirus, a viral family responsible for mild respiratory tract infections in a wide variety of animals including humans, pigs, cows, mice, cats, and birds. Analyses to date have been unable to identify the precise origin of the SARS coronavirus. We used Bayesian, neighbor-joining, and split decomposition phylogenetic techniques on the SARS virus replicase, surface spike, matrix, and nucleocapsid proteins to reveal the evolutionary origin of this recently emerging infectious agent. The analyses support a mammalian-like origin for the replicase protein, an avian-like origin for the matrix and nucleocapsid proteins, and a mammalian-avian mosaic origin for the host-determining spike protein. A bootscan recombination analysis of the spike gene revealed high nucleotide identity between the SARS virus and a feline infectious peritonitis virus throughout the gene, except for a 200-base-pair region of high identity to an avian sequence. These data support the phylogenetic analyses and suggest a possible past recombination event between mammalian-like and avian-like parent viruses. This event occurred near a region that has been implicated to be the human receptor binding site and may have been directly responsible for the switch of host of the SARS coronavirus from animals to humans.
Affiliations:
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Le document en format XML
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Guttman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Botany, University of Toronto</s1><s2>Toronto, Ontario M5S 3B2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biological Evolution</term><term>Computational Biology (methods)</term><term>Coronavirus</term><term>Evolution</term><term>Humans</term><term>Membrane Glycoproteins (genetics)</term><term>Microbiology</term><term>Nucleocapsid Proteins (genetics)</term><term>Phylogeny</term><term>Polyproteins (genetics)</term><term>Recombination, Genetic</term><term>SARS Virus (genetics)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severe acute respiratory syndrome</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Matrix Proteins (genetics)</term><term>Viral Proteins (genetics)</term><term>Virology</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Biologie informatique ()</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (génétique)</term><term>Humains</term><term>Phylogénie</term><term>Polyprotéines (génétique)</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines de la matrice virale (génétique)</term><term>Protéines nucléocapside (génétique)</term><term>Protéines virales (génétique)</term><term>Recombinaison génétique</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (génétique)</term><term>Évolution biologique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Nucleocapsid Proteins</term><term>Polyproteins</term><term>Viral Envelope Proteins</term><term>Viral Matrix Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Polyprotéines</term><term>Protéines de l'enveloppe virale</term><term>Protéines de la matrice virale</term><term>Protéines nucléocapside</term><term>Protéines virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Computational Biology</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Evolution</term><term>Humans</term><term>Phylogeny</term><term>Recombination, Genetic</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Biologie informatique</term><term>Coronavirus</term><term>Evolution</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Microbiologie</term><term>Phylogénie</term><term>Recombinaison génétique</term><term>Virologie</term><term>Syndrome respiratoire aigu sévère</term><term>Évolution biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a deadly form of pneumonia caused by a novel coronavirus, a viral family responsible for mild respiratory tract infections in a wide variety of animals including humans, pigs, cows, mice, cats, and birds. Analyses to date have been unable to identify the precise origin of the SARS coronavirus. We used Bayesian, neighbor-joining, and split decomposition phylogenetic techniques on the SARS virus replicase, surface spike, matrix, and nucleocapsid proteins to reveal the evolutionary origin of this recently emerging infectious agent. The analyses support a mammalian-like origin for the replicase protein, an avian-like origin for the matrix and nucleocapsid proteins, and a mammalian-avian mosaic origin for the host-determining spike protein. A bootscan recombination analysis of the spike gene revealed high nucleotide identity between the SARS virus and a feline infectious peritonitis virus throughout the gene, except for a 200-base-pair region of high identity to an avian sequence. These data support the phylogenetic analyses and suggest a possible past recombination event between mammalian-like and avian-like parent viruses. This event occurred near a region that has been implicated to be the human receptor binding site and may have been directly responsible for the switch of host of the SARS coronavirus from animals to humans.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Stavrinides, John" sort="Stavrinides, John" uniqKey="Stavrinides J" first="John" last="Stavrinides">John Stavrinides</name></region><name sortKey="Guttman, David S" sort="Guttman, David S" uniqKey="Guttman D" first="David S." last="Guttman">David S. Guttman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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