Mucosal immunisation of african green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS. Commentary
Identifieur interne : 005B03 ( Main/Exploration ); précédent : 005B02; suivant : 005B04Mucosal immunisation of african green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS. Commentary
Auteurs : Alexander Bukreyev [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Ursula J. Buchholz [États-Unis] ; Leatrice N. Vogel [États-Unis] ; William R. Elkins [États-Unis] ; Marisa St Claire [États-Unis] ; Brian R. Murphy [États-Unis] ; Kanta Subbarao [États-Unis] ; Peter L. Collins [États-Unis] ; A. R. Foxwell [Australie] ; A. W. Cripps [Australie]Source :
- Lancet : (British edition) [ 0140-6736 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccination, Singe, Médecine, Homme.
English descriptors
- KwdEn :
Abstract
Background The outbreak of severe acute respiratory syndrome (SARS) in 2002 was caused by a previously unknown coronavirus-SARS coronavirus (SARS-CoV). We have developed an experimental SARS vaccine for direct immunisation of the respiratory tract, the major site of SARS-coronavirus transmission and disease. Methods We expressed the complete SARS coronavirus envelope spike (S) protein from a recombinant attenuated parainfluenza virus (BHPIV3) that is being developed as a live attenuated, intranasal paediatric vaccine against human parainfluenza virus type 3 (HPIV3). We immunised eight African green monkeys, four with a single dose of BHPIV3/ SARS-S and four with a control, BHPIV3/Ctrl, administered via the respiratory tract. A SARS-coronavirus challenge was given to all monkeys 28 days after immunisation. Findings Immunisation of animals with BHPIV3/SARS-S induced the production of SARS-coronavirus-neutralising serum antibodies, indicating that a systemic immune response resulted from mucosal immunisation. After challenge with SARS coronavirus, all monkeys in the control group shed SARS coronavirus, with shedding lasting 5-8 days. No viral shedding occurred in the group immunised with BHPIV3/SARS-S. Interpretation A vectored mucosal vaccine expressing the SARS-coronavirus S protein alone may be highly effective in a single-dose format for the prevention of SARS.
Affiliations:
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African</term>
<term>Animal</term>
<term>Attenuated strain</term>
<term>Cercopithecus aethiops</term>
<term>Evaluation</term>
<term>Human</term>
<term>Immunization</term>
<term>Medicine</term>
<term>Monkey</term>
<term>Mucosa</term>
<term>Preclinical trial</term>
<term>Prevention</term>
<term>Severe acute respiratory syndrome</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Muqueuse</term>
<term>Prévention</term>
<term>Vaccination</term>
<term>Africain</term>
<term>Souche atténuée</term>
<term>Animal</term>
<term>Singe</term>
<term>Cercopithecus aethiops</term>
<term>Essai préclinique</term>
<term>Médecine</term>
<term>Homme</term>
<term>Immunisation</term>
<term>Evaluation</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccination</term>
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<front><div type="abstract" xml:lang="en">Background The outbreak of severe acute respiratory syndrome (SARS) in 2002 was caused by a previously unknown coronavirus-SARS coronavirus (SARS-CoV). We have developed an experimental SARS vaccine for direct immunisation of the respiratory tract, the major site of SARS-coronavirus transmission and disease. Methods We expressed the complete SARS coronavirus envelope spike (S) protein from a recombinant attenuated parainfluenza virus (BHPIV3) that is being developed as a live attenuated, intranasal paediatric vaccine against human parainfluenza virus type 3 (HPIV3). We immunised eight African green monkeys, four with a single dose of BHPIV3/ SARS-S and four with a control, BHPIV3/Ctrl, administered via the respiratory tract. A SARS-coronavirus challenge was given to all monkeys 28 days after immunisation. Findings Immunisation of animals with BHPIV3/SARS-S induced the production of SARS-coronavirus-neutralising serum antibodies, indicating that a systemic immune response resulted from mucosal immunisation. After challenge with SARS coronavirus, all monkeys in the control group shed SARS coronavirus, with shedding lasting 5-8 days. No viral shedding occurred in the group immunised with BHPIV3/SARS-S. Interpretation A vectored mucosal vaccine expressing the SARS-coronavirus S protein alone may be highly effective in a single-dose format for the prevention of SARS.</div>
</front>
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<tree><country name="États-Unis"><noRegion><name sortKey="Bukreyev, Alexander" sort="Bukreyev, Alexander" uniqKey="Bukreyev A" first="Alexander" last="Bukreyev">Alexander Bukreyev</name>
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<name sortKey="Buchholz, Ursula J" sort="Buchholz, Ursula J" uniqKey="Buchholz U" first="Ursula J." last="Buchholz">Ursula J. Buchholz</name>
<name sortKey="Collins, Peter L" sort="Collins, Peter L" uniqKey="Collins P" first="Peter L." last="Collins">Peter L. Collins</name>
<name sortKey="Elkins, William R" sort="Elkins, William R" uniqKey="Elkins W" first="William R." last="Elkins">William R. Elkins</name>
<name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name>
<name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name>
<name sortKey="St Claire, Marisa" sort="St Claire, Marisa" uniqKey="St Claire M" first="Marisa" last="St Claire">Marisa St Claire</name>
<name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<name sortKey="Vogel, Leatrice N" sort="Vogel, Leatrice N" uniqKey="Vogel L" first="Leatrice N." last="Vogel">Leatrice N. Vogel</name>
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<country name="Australie"><noRegion><name sortKey="Foxwell, A R" sort="Foxwell, A R" uniqKey="Foxwell A" first="A. R." last="Foxwell">A. R. Foxwell</name>
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<name sortKey="Cripps, A W" sort="Cripps, A W" uniqKey="Cripps A" first="A. W." last="Cripps">A. W. Cripps</name>
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