Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats
Identifieur interne : 001F86 ( Main/Exploration ); précédent : 001F85; suivant : 001F87Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats
Auteurs : Ann Demogines [États-Unis] ; Michael Farzan [États-Unis] ; Sara L. Sawyer [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Peptidyl-Dipeptidase A, Récepteurs viraux, Virus du SRAS.
- métabolisme : Peptidyl-Dipeptidase A, Récepteurs viraux.
- physiologie : Virus du SRAS.
- virologie : Chiroptera.
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Chiroptera (virology), Humans, Models, Molecular, Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), Receptors, Virus (genetics), Receptors, Virus (metabolism), SARS Virus (genetics), SARS Virus (physiology), Selection, Genetic, Severe acute respiratory syndrome, Virus Internalization.
- MESH :
- chemical , genetics : Peptidyl-Dipeptidase A, Receptors, Virus.
- chemical , metabolism : Peptidyl-Dipeptidase A, Receptors, Virus.
- genetics : SARS Virus.
- physiology : SARS Virus.
- virology : Chiroptera.
- Animals, Humans, Models, Molecular, Selection, Genetic, Virus Internalization.
Abstract
In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat ACE2 gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.
Url:
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000062
- to stream PascalFrancis, to step Curation: 000925
- to stream PascalFrancis, to step Checkpoint: 000060
- to stream Main, to step Merge: 002011
- to stream Pmc, to step Corpus: 000C69
- to stream Pmc, to step Curation: 000C69
- to stream Pmc, to step Checkpoint: 000A69
- to stream PubMed, to step Corpus: 001382
- to stream PubMed, to step Curation: 001382
- to stream PubMed, to step Checkpoint: 001357
- to stream Ncbi, to step Merge: 002478
- to stream Ncbi, to step Curation: 002478
- to stream Ncbi, to step Checkpoint: 002478
- to stream Main, to step Merge: 001D49
- to stream Main, to step Curation: 001F86
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats</title>
<author><name sortKey="Demogines, Ann" sort="Demogines, Ann" uniqKey="Demogines A" first="Ann" last="Demogines">Ann Demogines</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin</s1>
<s2>Austin, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
<settlement type="city">Austin (Texas)</settlement>
</placeName>
<orgName type="university">Université du Texas à Austin</orgName>
</affiliation>
</author>
<author><name sortKey="Farzan, Michael" sort="Farzan, Michael" uniqKey="Farzan M" first="Michael" last="Farzan">Michael Farzan</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center</s1>
<s2>Southborough, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sawyer, Sara L" sort="Sawyer, Sara L" uniqKey="Sawyer S" first="Sara L." last="Sawyer">Sara L. Sawyer</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin</s1>
<s2>Austin, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
<settlement type="city">Austin (Texas)</settlement>
</placeName>
<orgName type="university">Université du Texas à Austin</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0227829</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0227829 INIST</idno>
<idno type="RBID">Pascal:12-0227829</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000062</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000925</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000060</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000060</idno>
<idno type="wicri:doubleKey">0022-538X:2012:Demogines A:evidence:for:ace</idno>
<idno type="wicri:Area/Main/Merge">002011</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372174</idno>
<idno type="RBID">PMC:3372174</idno>
<idno type="wicri:Area/Pmc/Corpus">000C69</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C69</idno>
<idno type="wicri:Area/Pmc/Curation">000C69</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C69</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000A69</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A69</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:22438550</idno>
<idno type="wicri:Area/PubMed/Corpus">001382</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001382</idno>
<idno type="wicri:Area/PubMed/Curation">001382</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001382</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001357</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001357</idno>
<idno type="wicri:Area/Ncbi/Merge">002478</idno>
<idno type="wicri:Area/Ncbi/Curation">002478</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002478</idno>
<idno type="wicri:doubleKey">0022-538X:2012:Demogines A:evidence:for:ace</idno>
<idno type="wicri:Area/Main/Merge">001D49</idno>
<idno type="wicri:Area/Main/Curation">001F86</idno>
<idno type="wicri:Area/Main/Exploration">001F86</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats</title>
<author><name sortKey="Demogines, Ann" sort="Demogines, Ann" uniqKey="Demogines A" first="Ann" last="Demogines">Ann Demogines</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin</s1>
<s2>Austin, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
<settlement type="city">Austin (Texas)</settlement>
</placeName>
<orgName type="university">Université du Texas à Austin</orgName>
</affiliation>
</author>
<author><name sortKey="Farzan, Michael" sort="Farzan, Michael" uniqKey="Farzan M" first="Michael" last="Farzan">Michael Farzan</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center</s1>
<s2>Southborough, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sawyer, Sara L" sort="Sawyer, Sara L" uniqKey="Sawyer S" first="Sara L." last="Sawyer">Sara L. Sawyer</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin</s1>
<s2>Austin, Texas</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
<settlement type="city">Austin (Texas)</settlement>
</placeName>
<orgName type="university">Université du Texas à Austin</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Chiroptera (virology)</term>
<term>Humans</term>
<term>Models, Molecular</term>
<term>Peptidyl-Dipeptidase A (genetics)</term>
<term>Peptidyl-Dipeptidase A (metabolism)</term>
<term>Receptors, Virus (genetics)</term>
<term>Receptors, Virus (metabolism)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (physiology)</term>
<term>Selection, Genetic</term>
<term>Severe acute respiratory syndrome</term>
<term>Virus Internalization</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chiroptera (virologie)</term>
<term>Humains</term>
<term>Modèles moléculaires</term>
<term>Peptidyl-Dipeptidase A (génétique)</term>
<term>Peptidyl-Dipeptidase A (métabolisme)</term>
<term>Pénétration virale</term>
<term>Récepteurs viraux (génétique)</term>
<term>Récepteurs viraux (métabolisme)</term>
<term>Sélection génétique</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term>
<term>Receptors, Virus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term>
<term>Receptors, Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term>
<term>Récepteurs viraux</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term>
<term>Récepteurs viraux</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Models, Molecular</term>
<term>Selection, Genetic</term>
<term>Virus Internalization</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Modèles moléculaires</term>
<term>Pénétration virale</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Sélection génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat ACE2 gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Texas</li>
</region>
<settlement><li>Austin (Texas)</li>
</settlement>
<orgName><li>Université du Texas à Austin</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Demogines, Ann" sort="Demogines, Ann" uniqKey="Demogines A" first="Ann" last="Demogines">Ann Demogines</name>
</region>
<name sortKey="Farzan, Michael" sort="Farzan, Michael" uniqKey="Farzan M" first="Michael" last="Farzan">Michael Farzan</name>
<name sortKey="Sawyer, Sara L" sort="Sawyer, Sara L" uniqKey="Sawyer S" first="Sara L." last="Sawyer">Sara L. Sawyer</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F86 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F86 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:12-0227829 |texte= Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats }}
This area was generated with Dilib version V0.6.33. |