Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats
Identifieur interne : 002478 ( Ncbi/Checkpoint ); précédent : 002477; suivant : 002479Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats
Auteurs : Ann Demogines [États-Unis] ; Michael Farzan [États-Unis] ; Sara L. Sawyer [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Peptidyl-Dipeptidase A, Récepteurs viraux, Virus du SRAS.
- métabolisme : Peptidyl-Dipeptidase A, Récepteurs viraux.
- physiologie : Virus du SRAS.
- virologie : Chiroptera.
- Animaux, Humains, Modèles moléculaires, Pénétration virale, Sélection génétique.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Peptidyl-Dipeptidase A, Receptors, Virus.
- chemical , metabolism : Peptidyl-Dipeptidase A, Receptors, Virus.
- genetics : SARS Virus.
- physiology : SARS Virus.
- virology : Chiroptera.
- Animals, Humans, Models, Molecular, Selection, Genetic, Virus Internalization.
Abstract
In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat
Url:
DOI: 10.1128/JVI.00311-12
PubMed: 22438550
PubMed Central: 3372174
Affiliations:
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PMC:3372174Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat <italic>ACE2</italic>
gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.</p>
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