SrasV1, Main, Exploration, bibRecordById, PMC:1693394

The aetiology of SARS: Koch's postulates fulfilled.

Identifieur interne : 005028 ( Main/Exploration ); précédent : 005027; suivant : 005029

The aetiology of SARS: Koch's postulates fulfilled.

Auteurs : A D M E. Osterhaus ; R A M. Fouchier ; T. Kuiken

Source :

Philosophical Transactions of the Royal Society B: Biological Sciences [ 0962-8436 ] ; 2004.

RBID : PMC:1693394

Descripteurs français

KwdFr :
- Animaux, Chats, Furets, Humains, Macaca fascicularis, Modèles animaux de maladie humaine, Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (étiologie), Virus du SRAS, Zoonoses (transmission).
MESH :
- physiopathologie : Syndrome respiratoire aigu sévère.
- étiologie : Syndrome respiratoire aigu sévère, Zoonoses.
- Animaux, Chats, Furets, Humains, Macaca fascicularis, Modèles animaux de maladie humaine, Virus du SRAS.

English descriptors

KwdEn :
- Animals, Cats, Disease Models, Animal, Ferrets, Humans, Macaca fascicularis, SARS Virus, Severe Acute Respiratory Syndrome (etiology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (transmission), Zoonoses (transmission).
MESH :
- etiology : Severe Acute Respiratory Syndrome.
- physiopathology : Severe Acute Respiratory Syndrome.
- transmission : Severe Acute Respiratory Syndrome, Zoonoses.
- Animals, Cats, Disease Models, Animal, Ferrets, Humans, Macaca fascicularis, SARS Virus.

Abstract

Proof that a newly identified coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV) is the primary cause of severe acute respiratory syndrome (SARS) came from a series of studies on experimentally infected cynomolgus macaques (Macaca fascicularis). SARS-CoV-infected macaques developed a disease comparable to SARS in humans; the virus was re-isolated from these animals and they developed SARS-CoV-specific antibodies. This completed the fulfilment of Koch's postulates, as modified by Rivers for viral diseases, for SARS-CoV as the aetiological agent of SARS. Besides the macaque model, a ferret and a cat model for SARS-CoV were also developed. These animal models allow comparative pathogenesis studies for SARS-CoV infections and testing of different intervention strategies. The first of these studies has shown that pegylated interferon-alpha, a drug approved for human use, limits SARS-CoV replication and lung damage in experimentally infected macaques. Finally, we argue that, given the worldwide nature of the socio-economic changes that have predisposed for the emergence of SARS and avian influenza in Southeast Asia, such changes herald the beginning of a global trend for which we are ill prepared.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693394

DOI: 10.1098/rstb.2004.1489
PubMed: 15306393
PubMed Central: 1693394

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Proof that a newly identified coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV) is the primary cause of severe acute respiratory syndrome (SARS) came from a series of studies on experimentally infected cynomolgus macaques (Macaca fascicularis). SARS-CoV-infected macaques developed a disease comparable to SARS in humans; the virus was re-isolated from these animals and they developed SARS-CoV-specific antibodies. This completed the fulfilment of Koch's postulates, as modified by Rivers for viral diseases, for SARS-CoV as the aetiological agent of SARS. Besides the macaque model, a ferret and a cat model for SARS-CoV were also developed. These animal models allow comparative pathogenesis studies for SARS-CoV infections and testing of different intervention strategies. The first of these studies has shown that pegylated interferon-alpha, a drug approved for human use, limits SARS-CoV replication and lung damage in experimentally infected macaques. Finally, we argue that, given the worldwide nature of the socio-economic changes that have predisposed for the emergence of SARS and avian influenza in Southeast Asia, such changes herald the beginning of a global trend for which we are ill prepared.</p>
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The aetiology of SARS: Koch's postulates fulfilled.

The aetiology of SARS: Koch's postulates fulfilled.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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