The aetiology of SARS: Koch's postulates fulfilled.
Identifieur interne : 002991 ( PubMed/Checkpoint ); précédent : 002990; suivant : 002992The aetiology of SARS: Koch's postulates fulfilled.
Auteurs : A D M E. Osterhaus [Pays-Bas] ; R A M. Fouchier ; T. KuikenSource :
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences [ 0962-8436 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- physiopathologie : Syndrome respiratoire aigu sévère.
- étiologie : Syndrome respiratoire aigu sévère, Zoonoses.
- Animaux, Chats, Furets, Humains, Macaca fascicularis, Modèles animaux de maladie humaine, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- etiology : Severe Acute Respiratory Syndrome.
- physiopathology : Severe Acute Respiratory Syndrome.
- transmission : Severe Acute Respiratory Syndrome, Zoonoses.
- Animals, Cats, Disease Models, Animal, Ferrets, Humans, Macaca fascicularis, SARS Virus.
Abstract
Proof that a newly identified coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV) is the primary cause of severe acute respiratory syndrome (SARS) came from a series of studies on experimentally infected cynomolgus macaques (Macaca fascicularis). SARS-CoV-infected macaques developed a disease comparable to SARS in humans; the virus was re-isolated from these animals and they developed SARS-CoV-specific antibodies. This completed the fulfilment of Koch's postulates, as modified by Rivers for viral diseases, for SARS-CoV as the aetiological agent of SARS. Besides the macaque model, a ferret and a cat model for SARS-CoV were also developed. These animal models allow comparative pathogenesis studies for SARS-CoV infections and testing of different intervention strategies. The first of these studies has shown that pegylated interferon-alpha, a drug approved for human use, limits SARS-CoV replication and lung damage in experimentally infected macaques. Finally, we argue that, given the worldwide nature of the socio-economic changes that have predisposed for the emergence of SARS and avian influenza in Southeast Asia, such changes herald the beginning of a global trend for which we are ill prepared.
DOI: 10.1098/rstb.2004.1489
PubMed: 15306393
Affiliations:
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<front><div type="abstract" xml:lang="en">Proof that a newly identified coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV) is the primary cause of severe acute respiratory syndrome (SARS) came from a series of studies on experimentally infected cynomolgus macaques (Macaca fascicularis). SARS-CoV-infected macaques developed a disease comparable to SARS in humans; the virus was re-isolated from these animals and they developed SARS-CoV-specific antibodies. This completed the fulfilment of Koch's postulates, as modified by Rivers for viral diseases, for SARS-CoV as the aetiological agent of SARS. Besides the macaque model, a ferret and a cat model for SARS-CoV were also developed. These animal models allow comparative pathogenesis studies for SARS-CoV infections and testing of different intervention strategies. The first of these studies has shown that pegylated interferon-alpha, a drug approved for human use, limits SARS-CoV replication and lung damage in experimentally infected macaques. Finally, we argue that, given the worldwide nature of the socio-economic changes that have predisposed for the emergence of SARS and avian influenza in Southeast Asia, such changes herald the beginning of a global trend for which we are ill prepared.</div>
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