A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses
Identifieur interne : 004955 ( Main/Exploration ); précédent : 004954; suivant : 004956A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses
Auteurs : Ali Azizi ; Susan Aucoin ; Helina Tadesse ; Rita Frost ; Masoud Ghorbani ; Catalina Soare ; Turaya Naas ; Francisco Diaz-MitomaSource :
- Genetic Vaccines and Therapy [ 1479-0556 ] ; 2005.
Abstract
Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses. Several groups of mice were immunized alone or in combination with SARS-nucleocapsid immunogen. A high level of specific SARS-CD8+ T-cell response was demonstrated in mice that received DNA encoding the SARS-nucleocapsid, protein and XIAP as an adjuvant. We also observed that co-administration of a plasmid expressing nucleocapsid, recombinant protein and montanide/CpG induces high antibody titers in immunized mice. Moreover, this vaccine approach merits further investigation as a potential candidate vaccine against SARS.
The online version of this article (doi:10.1186/1479-0556-3-7) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1479-0556-3-7
PubMed: 16115319
PubMed Central: 1249587
Affiliations:
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- to stream Main, to step Curation: 004955
Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses. Several groups of mice were immunized alone or in combination with SARS-nucleocapsid immunogen. A high level of specific SARS-CD8+ T-cell response was demonstrated in mice that received DNA encoding the SARS-nucleocapsid, protein and XIAP as an adjuvant. We also observed that co-administration of a plasmid expressing nucleocapsid, recombinant protein and montanide/CpG induces high antibody titers in immunized mice. Moreover, this vaccine approach merits further investigation as a potential candidate vaccine against SARS.</p>
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<p>The online version of this article (doi:10.1186/1479-0556-3-7) contains supplementary material, which is available to authorized users.</p>
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