SrasV1, Main, Exploration, bibRecord, 004C79

An interferon‐γ‐related cytokine storm in SARS patients

Identifieur interne : 004C79 ( Main/Exploration ); précédent : 004C78; suivant : 004C80

An interferon‐γ‐related cytokine storm in SARS patients

Auteurs : Kao-Jean Huang [Taïwan] ; Ih-Jen Su [Taïwan] ; Michel Theron [Taïwan] ; Yi-Chun Wu [Taïwan] ; Shu-Kuan Lai [Taïwan] ; Ching-Chuan Liu [Taïwan] ; Huan-Yao Lei [Taïwan]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2005-02.

RBID : ISTEX:7E668DE065E11CC43E91DAB2D3B9C67B607090C0

Descripteurs français

Pascal (Inist)
- Cytokine, Dengue hémorragique, Enterovirus, Fièvre hémorragique, Homme, Hémorragie, Interféron gamma, Oedème, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cytokine, Dengue hemorrhagic fever, Edema, Enterovirus, Gamma interferon, Hemorrhage, Hemorrhagic fever, Human, Severe acute respiratory syndrome.
Teeft :
- Apoptosis, Chan, Chemokine, Chemokine production, Chemokines, Coronavirus, Cytokine, Cytokine levels, Cytokine storm, Days post fever onset, Death group, Dengue, Dengue dengue hemorrhagic fever, Dengue hemorrhagic fever, Early stage, Edema, Epithelial, Hemorrhagic, Huang, Intravenous immunoglobulin, Kinetic changes, Laboratory data, Lymphocyte, Monocyte, Neutrophil, Neutrophils count, Positive association, Pulmonary edema, Reciprocal relationship, Respiratory syndrome, Sars, Sars patients, Serum level, Survival group, Syndrome, Wang.

Abstract

Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/ark:/67375/WNG-G7Z3D7ZD-8/fulltext.pdf

DOI: 10.1002/jmv.20255

Affiliations:

Taïwan

Le document en format XML

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<front><div type="abstract" xml:lang="en">Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.</div>
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An interferon‐γ‐related cytokine storm in SARS patients

An interferon‐γ‐related cytokine storm in SARS patients

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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