An interferon‐γ‐related cytokine storm in SARS patients
Identifieur interne : 000313 ( Istex/Corpus ); précédent : 000312; suivant : 000314An interferon‐γ‐related cytokine storm in SARS patients
Auteurs : Kao-Jean Huang ; Ih-Jen Su ; Michel Theron ; Yi-Chun Wu ; Shu-Kuan Lai ; Ching-Chuan Liu ; Huan-Yao LeiSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2005-02.
English descriptors
- Teeft :
- Apoptosis, Chan, Chemokine, Chemokine production, Chemokines, Coronavirus, Cytokine, Cytokine levels, Cytokine storm, Days post fever onset, Death group, Dengue, Dengue dengue hemorrhagic fever, Dengue hemorrhagic fever, Early stage, Edema, Epithelial, Hemorrhagic, Huang, Intravenous immunoglobulin, Kinetic changes, Laboratory data, Lymphocyte, Monocyte, Neutrophil, Neutrophils count, Positive association, Pulmonary edema, Reciprocal relationship, Respiratory syndrome, Sars, Sars patients, Serum level, Survival group, Syndrome, Wang.
Abstract
Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20255
Links to Exploration step
ISTEX:7E668DE065E11CC43E91DAB2D3B9C67B607090C0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">An interferon‐γ‐related cytokine storm in SARS patients</title><author><name sortKey="Huang, Kao Ean" sort="Huang, Kao Ean" uniqKey="Huang K" first="Kao-Jean" last="Huang">Kao-Jean Huang</name><affiliation><mods:affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Su, Ih En" sort="Su, Ih En" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><affiliation><mods:affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Clinical Research, National Health of Research Institute, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Theron, Michel" sort="Theron, Michel" uniqKey="Theron M" first="Michel" last="Theron">Michel Theron</name><affiliation><mods:affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Wu, Yi Hun" sort="Wu, Yi Hun" uniqKey="Wu Y" first="Yi-Chun" last="Wu">Yi-Chun Wu</name><affiliation><mods:affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lai, Shu Uan" sort="Lai, Shu Uan" uniqKey="Lai S" first="Shu-Kuan" last="Lai">Shu-Kuan Lai</name><affiliation><mods:affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Liu, Ching Huan" sort="Liu, Ching Huan" uniqKey="Liu C" first="Ching-Chuan" last="Liu">Ching-Chuan Liu</name><affiliation><mods:affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lei, Huan Ao" sort="Lei, Huan Ao" uniqKey="Lei H" first="Huan-Yao" last="Lei">Huan-Yao Lei</name><affiliation><mods:affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hylei@mail.ncku.edu.tw.</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.===</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7E668DE065E11CC43E91DAB2D3B9C67B607090C0</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/jmv.20255</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-G7Z3D7ZD-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000313</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000313</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">An interferon‐γ‐related cytokine storm in SARS patients</title><author><name sortKey="Huang, Kao Ean" sort="Huang, Kao Ean" uniqKey="Huang K" first="Kao-Jean" last="Huang">Kao-Jean Huang</name><affiliation><mods:affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Su, Ih En" sort="Su, Ih En" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><affiliation><mods:affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Clinical Research, National Health of Research Institute, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Theron, Michel" sort="Theron, Michel" uniqKey="Theron M" first="Michel" last="Theron">Michel Theron</name><affiliation><mods:affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Wu, Yi Hun" sort="Wu, Yi Hun" uniqKey="Wu Y" first="Yi-Chun" last="Wu">Yi-Chun Wu</name><affiliation><mods:affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lai, Shu Uan" sort="Lai, Shu Uan" uniqKey="Lai S" first="Shu-Kuan" last="Lai">Shu-Kuan Lai</name><affiliation><mods:affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Liu, Ching Huan" sort="Liu, Ching Huan" uniqKey="Liu C" first="Ching-Chuan" last="Liu">Ching-Chuan Liu</name><affiliation><mods:affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lei, Huan Ao" sort="Lei, Huan Ao" uniqKey="Lei H" first="Huan-Yao" last="Lei">Huan-Yao Lei</name><affiliation><mods:affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hylei@mail.ncku.edu.tw.</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.===</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">75</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="185">185</biblScope><biblScope unit="page" to="194">194</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-02">2005-02</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Apoptosis</term><term>Chan</term><term>Chemokine</term><term>Chemokine production</term><term>Chemokines</term><term>Coronavirus</term><term>Cytokine</term><term>Cytokine levels</term><term>Cytokine storm</term><term>Days post fever onset</term><term>Death group</term><term>Dengue</term><term>Dengue dengue hemorrhagic fever</term><term>Dengue hemorrhagic fever</term><term>Early stage</term><term>Edema</term><term>Epithelial</term><term>Hemorrhagic</term><term>Huang</term><term>Intravenous immunoglobulin</term><term>Kinetic changes</term><term>Laboratory data</term><term>Lymphocyte</term><term>Monocyte</term><term>Neutrophil</term><term>Neutrophils count</term><term>Positive association</term><term>Pulmonary edema</term><term>Reciprocal relationship</term><term>Respiratory syndrome</term><term>Sars</term><term>Sars patients</term><term>Serum level</term><term>Survival group</term><term>Syndrome</term><term>Wang</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>cytokine</json:string><json:string>sars</json:string><json:string>sars patients</json:string><json:string>dengue</json:string><json:string>chemokine</json:string><json:string>chemokines</json:string><json:string>neutrophil</json:string><json:string>survival group</json:string><json:string>cytokine storm</json:string><json:string>hemorrhagic</json:string><json:string>lymphocyte</json:string><json:string>pulmonary edema</json:string><json:string>huang</json:string><json:string>wang</json:string><json:string>respiratory syndrome</json:string><json:string>coronavirus</json:string><json:string>chan</json:string><json:string>epithelial</json:string><json:string>monocyte</json:string><json:string>apoptosis</json:string><json:string>death group</json:string><json:string>early stage</json:string><json:string>reciprocal relationship</json:string><json:string>chemokine production</json:string><json:string>positive association</json:string><json:string>dengue hemorrhagic fever</json:string><json:string>syndrome</json:string><json:string>edema</json:string><json:string>neutrophils count</json:string><json:string>dengue dengue hemorrhagic fever</json:string><json:string>kinetic changes</json:string><json:string>cytokine levels</json:string><json:string>days post fever onset</json:string><json:string>serum level</json:string><json:string>intravenous immunoglobulin</json:string><json:string>laboratory data</json:string></teeft></keywords><author><json:item><name>Kao‐Jean Huang</name><affiliations><json:string>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Ih‐Jen Su</name><affiliations><json:string>Center for Disease Control, Department of Health, Taipei, Taiwan</json:string><json:string>Division of Clinical Research, National Health of Research Institute, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Michel Theron</name><affiliations><json:string>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Yi‐Chun Wu</name><affiliations><json:string>Center for Disease Control, Department of Health, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Shu‐Kuan Lai</name><affiliations><json:string>Center for Disease Control, Department of Health, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Ching‐Chuan Liu</name><affiliations><json:string>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Huan‐Yao Lei</name><affiliations><json:string>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>E-mail: hylei@mail.ncku.edu.tw.</json:string><json:string>Correspondence address: Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.===</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>SARS</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SARS‐CoV</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cytokine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>interferon‐gamma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>enterovirus 71</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pulmonary edema</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dengue hemorrhagic fever</value></json:item></subject><articleId><json:string>JMV20255</json:string></articleId><arkIstex>ark:/67375/WNG-G7Z3D7ZD-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>8.72</score><pdfWordCount>4860</pdfWordCount><pdfCharCount>30694</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>594 x 792 pts</pdfPageSize><pdfWordsPerPage>486</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>155</abstractWordCount><abstractCharCount>1029</abstractCharCount><keywordCount>7</keywordCount></qualityIndicators><title>An interferon‐γ‐related cytokine storm in SARS patients</title><pmid><json:string>15602737</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9071</json:string></doi><issn><json:string>0146-6615</json:string></issn><eissn><json:string>1096-9071</json:string></eissn><publisherId><json:string>JMV</json:string></publisherId><volume>75</volume><issue>2</issue><pages><first>185</first><last>194</last><total>10</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Research Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>2005</json:string></date><geogName></geogName><orgName><json:string>Taiwan SARS</json:string><json:string>Biological Laboratories Co.</json:string><json:string>National Cheng Kung University, Tainan, Taiwan</json:string><json:string>SARS Research Project</json:string><json:string>D Systems, Inc.</json:string><json:string>LISS, INC</json:string><json:string>Laboratory Investigation</json:string><json:string>Department of Health, Taipei, Taiwan</json:string><json:string>Department of Microbiology and Immunology</json:string><json:string>Division of Clinical Research</json:string><json:string>National Health Insurance Bureau-Taiwan</json:string><json:string>Wiley-Liss, Inc</json:string><json:string>-Taiwan and SARS</json:string><json:string>Division of Disease Surveillance</json:string><json:string>SPSS, Inc., Chicago</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Yao Lei</json:string><json:string>J. Med</json:string><json:string>Jen Su</json:string><json:string>Yi-Chun Wu</json:string><json:string>Huan-Yao Lei</json:string><json:string>Michel Theron</json:string><json:string>Death</json:string></persName><placeName><json:string>Minneapolis</json:string><json:string>San Diego</json:string><json:string>Nagoya</json:string><json:string>Taiwan</json:string><json:string>Japan</json:string><json:string>CA</json:string><json:string>Taipei</json:string><json:string>MN</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Liu et al., 2002</json:string><json:string>Sobek et al., 2002</json:string><json:string>Ksiazek et al., 2003</json:string><json:string>Wen et al., 1997</json:string><json:string>Bernabei et al., 2001</json:string><json:string>So et al., 2003</json:string><json:string>Ng et al., 2004</json:string><json:string>Wu et al., 2004b</json:string><json:string>Peiris et al., 2003b</json:string><json:string>Cinatl et al., 2004</json:string><json:string>Miller et al., 2004</json:string><json:string>Peiris et al., 2003a,b</json:string><json:string>Glass et al., 2004</json:string><json:string>Pang et al., 2003</json:string><json:string>Wu et al., 2004a</json:string><json:string>Nicholls et al., 2003</json:string><json:string>Dhainaut et al., 2003</json:string><json:string>Haagmans et al., 2004</json:string><json:string>Wong et al., 2004</json:string><json:string>Wang et al., 2003</json:string><json:string>Krein and Winston, 2002</json:string><json:string>Tan et al., 2004</json:string><json:string>Ishiguro et al.</json:string><json:string>Zhang et al., 2004</json:string><json:string>Hung et al., 2004</json:string><json:string>Huang et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-G7Z3D7ZD-8</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1002/jmv.20255</json:string></doi><id>7E668DE065E11CC43E91DAB2D3B9C67B607090C0</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-G7Z3D7ZD-8/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-G7Z3D7ZD-8/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-G7Z3D7ZD-8/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">An interferon‐γ‐related cytokine storm in SARS patients</title><title level="a" type="short" xml:lang="en">Cytokine Storm in SARS</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><licence>Copyright © 2004 Wiley‐Liss, Inc.</licence></availability><date type="published" when="2005-02"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">An interferon‐γ‐related cytokine storm in SARS patients</title><title level="a" type="short" xml:lang="en">Cytokine Storm in SARS</title><author xml:id="author-0000"><persName><forename type="first">Kao‐Jean</forename><surname>Huang</surname></persName><affiliation><orgName type="division">Departments of Basic Medicine</orgName><orgName type="department">Microbiology and Immunology</orgName><orgName type="institution">College of Medicine</orgName><orgName type="institution">National Cheng Kung University</orgName><address><addrLine>Tainan</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Ih‐Jen</forename><surname>Su</surname></persName><affiliation><orgName type="institution">Center for Disease Control</orgName><orgName type="division">Department of Health</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation><affiliation><orgName type="laboratory">Division of Clinical Research</orgName><orgName type="institution">National Health of Research Institute</orgName><address><addrLine>Tainan</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Michel</forename><surname>Theron</surname></persName><affiliation><orgName type="division">Departments of Basic Medicine</orgName><orgName type="department">Microbiology and Immunology</orgName><orgName type="institution">College of Medicine</orgName><orgName type="institution">National Cheng Kung University</orgName><address><addrLine>Tainan</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Yi‐Chun</forename><surname>Wu</surname></persName><affiliation><orgName type="institution">Center for Disease Control</orgName><orgName type="division">Department of Health</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Shu‐Kuan</forename><surname>Lai</surname></persName><affiliation><orgName type="institution">Center for Disease Control</orgName><orgName type="division">Department of Health</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Ching‐Chuan</forename><surname>Liu</surname></persName><affiliation><orgName type="division">Departments of Basic Medicine</orgName><orgName type="department">Microbiology and Immunology</orgName><orgName type="institution">College of Medicine</orgName><orgName type="institution">National Cheng Kung University</orgName><address><addrLine>Tainan</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0006" role="corresp"><persName><forename type="first">Huan‐Yao</forename><surname>Lei</surname></persName><email>hylei@mail.ncku.edu.tw.</email><affiliation><orgName type="division">Departments of Basic Medicine</orgName><orgName type="department">Microbiology and Immunology</orgName><orgName type="institution">College of Medicine</orgName><orgName type="institution">National Cheng Kung University</orgName><address><addrLine>Tainan</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><idno type="istex">7E668DE065E11CC43E91DAB2D3B9C67B607090C0</idno><idno type="ark">ark:/67375/WNG-G7Z3D7ZD-8</idno><idno type="DOI">10.1002/jmv.20255</idno><idno type="unit">JMV20255</idno><idno type="toTypesetVersion">file:JMV.JMV20255.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="pISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><idno type="book-DOI">10.1002/(ISSN)1096-9071</idno><idno type="book-part-DOI">10.1002/jmv.v75:2</idno><idno type="product">JMV</idno><imprint><biblScope unit="vol">75</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="185">185</biblScope><biblScope unit="page" to="194">194</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">SARS</term><term xml:id="kwd2">SARS‐CoV</term><term xml:id="kwd3">cytokine</term><term xml:id="kwd4">interferon‐gamma</term><term xml:id="kwd5">enterovirus 71</term><term xml:id="kwd6">pulmonary edema</term><term xml:id="kwd7">dengue hemorrhagic fever</term></keywords><keywords rend="articleCategory"><term>Research Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-G7Z3D7ZD-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-9071</doi><issn type="print">0146-6615</issn><issn type="electronic">1096-9071</issn><idGroup><id type="product" value="JMV"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF MEDICAL VIROLOGY">Journal of Medical Virology</title><title type="short">J. Med. Virol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley" registered="yes">10.1002/jmv.v75:2</doi><numberingGroup><numbering type="journalVolume" number="75">75</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2005-02">February 2005</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="2" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jmv.20255</doi><idGroup><id type="unit" value="JMV20255"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title></titleGroup><copyright ownership="publisher">Copyright © 2004 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptAccepted" date="2004-10-15"></event><event type="firstOnline" date="2004-12-15"></event><event type="publishedOnlineFinalForm" date="2004-12-15"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-20"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">185</numbering><numbering type="pageLast">194</numbering></numberingGroup><correspondenceTo>Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JMV.JMV20255.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="26"></count><count type="wordTotal" number="1042"></count></countGroup><titleGroup><title type="main" xml:lang="en">An interferon‐γ‐related cytokine storm in SARS patients<link href="#fn1"></link></title><title type="short" xml:lang="en">Cytokine Storm in SARS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Kao‐Jean</givenNames><familyName>Huang</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Ih‐Jen</givenNames><familyName>Su</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michel</givenNames><familyName>Theron</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Yi‐Chun</givenNames><familyName>Wu</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Shu‐Kuan</givenNames><familyName>Lai</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ching‐Chuan</givenNames><familyName>Liu</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Huan‐Yao</givenNames><familyName>Lei</familyName></personName><contactDetails><email>hylei@mail.ncku.edu.tw.</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="TW" type="organization"><unparsedAffiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="TW" type="organization"><unparsedAffiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="TW" type="organization"><unparsedAffiliation>Division of Clinical Research, National Health of Research Institute, Tainan, Taiwan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">SARS</keyword><keyword xml:id="kwd2">SARS‐CoV</keyword><keyword xml:id="kwd3">cytokine</keyword><keyword xml:id="kwd4">interferon‐gamma</keyword><keyword xml:id="kwd5">enterovirus 71</keyword><keyword xml:id="kwd6">pulmonary edema</keyword><keyword xml:id="kwd7">dengue hemorrhagic fever</keyword></keywordGroup><fundingInfo><fundingAgency>National Science Council, Taiwan (SARS Research Project)</fundingAgency><fundingNumber>NSC92‐2751‐B006‐007</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Meeting presentation: International Conference of Influenza and the Resurgence of Severe Acute Respiratory Syndrome held on 28–31 October 2003, in Taipei, Taiwan. Abstract No. Session V‐2.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>An interferon‐γ‐related cytokine storm in SARS patients</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cytokine Storm in SARS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>An interferon‐γ‐related cytokine storm in SARS patients</title></titleInfo><name type="personal"><namePart type="given">Kao‐Jean</namePart><namePart type="family">Huang</namePart><affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ih‐Jen</namePart><namePart type="family">Su</namePart><affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</affiliation><affiliation>Division of Clinical Research, National Health of Research Institute, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michel</namePart><namePart type="family">Theron</namePart><affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yi‐Chun</namePart><namePart type="family">Wu</namePart><affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shu‐Kuan</namePart><namePart type="family">Lai</namePart><affiliation>Center for Disease Control, Department of Health, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ching‐Chuan</namePart><namePart type="family">Liu</namePart><affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Huan‐Yao</namePart><namePart type="family">Lei</namePart><affiliation>Departments of Basic Medicine, Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>E-mail: hylei@mail.ncku.edu.tw.</affiliation><affiliation>Correspondence address: Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-02</dateIssued><dateValid encoding="w3cdtf">2004-10-15</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">5</extent><extent unit="tables">3</extent><extent unit="references">26</extent><extent unit="words">1042</extent></physicalDescription><abstract lang="en">Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.</abstract><note type="content">*Meeting presentation: International Conference of Influenza and the Resurgence of Severe Acute Respiratory Syndrome held on 28–31 October 2003, in Taipei, Taiwan. Abstract No. Session V‐2.</note><note type="funding">National Science Council, Taiwan (SARS Research Project) - No. NSC92‐2751‐B006‐007; </note><subject lang="en"><genre>keywords</genre><topic>SARS</topic><topic>SARS‐CoV</topic><topic>cytokine</topic><topic>interferon‐gamma</topic><topic>enterovirus 71</topic><topic>pulmonary edema</topic><topic>dengue hemorrhagic fever</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. Virol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0146-6615</identifier><identifier type="eISSN">1096-9071</identifier><identifier type="DOI">10.1002/(ISSN)1096-9071</identifier><identifier type="PublisherID">JMV</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>185</start><end>194</end><total>10</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>The interferons and cell death: Guardians of the cell or accomplices of apoptosis?</title></titleInfo><name type="personal"><namePart type="given">GN</namePart><namePart type="family">Barber</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Barber GN. 2000. The interferons and cell death: Guardians of the cell or accomplices of apoptosis? Semin Cancer Biol 10: 103–111.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>103</start><end>111</end></extent></part><relatedItem type="host"><titleInfo><title>Semin Cancer Biol</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>103</start><end>111</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Interferon‐gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Bernabei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EM</namePart><namePart type="family">Coccia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Rigamonti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Bosticardo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Forni</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Pestka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CD</namePart><namePart type="family">Krause</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Battistini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Novelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bernabei P, Coccia EM, Rigamonti L, Bosticardo M, Forni G, Pestka S, Krause CD, Battistini A, Novelli F. 2001. Interferon‐gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death. J Leuko Biol 70: 950–960.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>950</start><end>960</end></extent></part><relatedItem type="host"><titleInfo><title>J Leuko Biol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>950</start><end>960</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus</title></titleInfo><name type="personal"><namePart type="given">JJ</namePart><namePart type="family">Cinatl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Hoever</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Morgenstern</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Preiser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JU</namePart><namePart type="family">Vogel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Hofmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Bauer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Michaelis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HF</namePart><namePart type="family">Rabenau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HW</namePart><namePart type="family">Doerr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cinatl JJ, Hoever G, Morgenstern B, Preiser W, Vogel JU, Hofmann WK, Bauer G, Michaelis M, Rabenau HF, Doerr HW. 2004. Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus. Cell Mol Life Sci 61: 2100–2112.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>61</number></detail><extent unit="pages"><start>2100</start><end>2112</end></extent></part><relatedItem type="host"><titleInfo><title>Cell Mol Life Sci</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>61</number></detail><extent unit="pages"><start>2100</start><end>2112</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Transforming growth factor‐beta: A mediator of cell regulation in acute respiratory distress syndrome</title></titleInfo><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Dhainaut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Charpentier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Chiche</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dhainaut JF, Charpentier J, Chiche JD. 2003. Transforming growth factor‐beta: A mediator of cell regulation in acute respiratory distress syndrome. Crit Care Med 31: S258–S264.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>S258</start><end>S264</end></extent></part><relatedItem type="host"><titleInfo><title>Crit Care Med</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>S258</start><end>S264</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Mechanisms of host defense following severe acute respiratory syndrome‐coronavirus (SARS‐CoV) pulmonary infection of mice</title></titleInfo><name type="personal"><namePart type="given">WG</namePart><namePart type="family">Glass</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Subbarao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Murphy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Murphy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Glass WG, Subbarao K, Murphy B, Murphy PM. 2004. Mechanisms of host defense following severe acute respiratory syndrome‐coronavirus (SARS‐CoV) pulmonary infection of mice. J Immunol 173: 4030–4039.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>4030</start><end>4039</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>4030</start><end>4039</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Pegylated interferon‐α protects type I pneumocytes against SARS coronavirus infection in macaques</title></titleInfo><name type="personal"><namePart type="given">BL</namePart><namePart type="family">Haagmans</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kuiken</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BE</namePart><namePart type="family">Martina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RAM</namePart><namePart type="family">Fouchier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GR</namePart><namePart type="family">Rimmelzwaan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Amerongen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Riel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Jong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Itamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Tashiro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ADME</namePart><namePart type="family">Osterhaus</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Haagmans BL, Kuiken T, Martina BE, Fouchier RAM, Rimmelzwaan GR, Amerongen G, Riel D, Jong T, Itamura S, Chan KH, Tashiro M, Osterhaus ADME. 2004. Pegylated interferon‐α protects type I pneumocytes against SARS coronavirus infection in macaques. Nat Med 10: 290–293.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>290</start><end>293</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Med</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>290</start><end>293</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Dengue hemorrhagic fever in infants: A study on clinical and cytokine profiles</title></titleInfo><name type="personal"><namePart type="given">NT</namePart><namePart type="family">Hung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HY</namePart><namePart type="family">Lei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NT</namePart><namePart type="family">Lan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YS</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KJ</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LB</namePart><namePart type="family">Lien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CF</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TM</namePart><namePart type="family">Yeh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DQ</namePart><namePart type="family">Ha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VTQ</namePart><namePart type="family">Huong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LC</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LT</namePart><namePart type="family">My</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Halstead</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hung NT, Lei HY, Lan NT, Lin YS, Huang KJ, Lien LB, Lin CF, Yeh TM, Ha DQ, Huong VTQ, Chen LC, Huang JH, My LT, Liu CC, Halstead SB. 2004. Dengue hemorrhagic fever in infants: A study on clinical and cytokine profiles. J Infect Dis 189: 221–232.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>189</number></detail><extent unit="pages"><start>221</start><end>232</end></extent></part><relatedItem type="host"><titleInfo><title>J Infect Dis</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>189</number></detail><extent unit="pages"><start>221</start><end>232</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Induction of interferon‐inducible protein‐10 and monokine induced by interferon‐γ from human endothelial cells infected with influenza A virus</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Ishiguro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Takada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Yoshioka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kikuta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kida</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kobayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ishiguro N, Takada A, Yoshioka M, Ma X, Kikuta H, Kida H, Kobayashi K. 2004. Induction of interferon‐inducible protein‐10 and monokine induced by interferon‐γ from human endothelial cells infected with influenza A virus. Arch Virol 149: 17–34.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>149</number></detail><extent unit="pages"><start>17</start><end>34</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Virol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>149</number></detail><extent unit="pages"><start>17</start><end>34</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Roles of insulin‐like growth factor I and transforming growth factor‐beta in fibrotic lung disease</title></titleInfo><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Krein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BW</namePart><namePart type="family">Winston</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Krein PM, Winston BW. 2002. Roles of insulin‐like growth factor I and transforming growth factor‐beta in fibrotic lung disease. Chest 122: 289S–293S.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>289S</start><end>293S</end></extent></part><relatedItem type="host"><titleInfo><title>Chest</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>289S</start><end>293S</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>A novel coronavirus associated with severe acute respiratory syndrome</title></titleInfo><name type="personal"><namePart type="given">TG</namePart><namePart type="family">Ksiazek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Erdman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CS</namePart><namePart type="family">Goldsmith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Zaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Peret</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Emery</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Urbani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Comer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PE</namePart><namePart type="family">Rollin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SF</namePart><namePart type="family">Dowell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AR</namePart><namePart type="family">Ling</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CD</namePart><namePart type="family">Humphrey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WJ</namePart><namePart type="family">Shieh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Guarner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CD</namePart><namePart type="family">Paddock</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Rota</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Fields</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">DeRisi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Hughes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">LeDuc</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WJ</namePart><namePart type="family">Bellini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LJ</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AR, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ. 2003. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 348: 1953–1966.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>348</number></detail><extent unit="pages"><start>1953</start><end>1966</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>348</number></detail><extent unit="pages"><start>1953</start><end>1966</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Double‐stranded RNA cooperates with interferon‐gamma and IL‐1 beta to induce both chemokine expression and nuclear factor‐kappa B‐dependent apoptosis in pancreatic beta‐cells: Potential mechanisms for viral‐induced insulitis and beta‐cell death in type I diabetes mellitus</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Cardozo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MI</namePart><namePart type="family">Darville</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Eizirik</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Liu D, Cardozo AK, Darville MI, Eizirik DL. 2002. Double‐stranded RNA cooperates with interferon‐gamma and IL‐1 beta to induce both chemokine expression and nuclear factor‐kappa B‐dependent apoptosis in pancreatic beta‐cells: Potential mechanisms for viral‐induced insulitis and beta‐cell death in type I diabetes mellitus. Endocrinology 143: 1225–1234.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>143</number></detail><extent unit="pages"><start>1225</start><end>1234</end></extent></part><relatedItem type="host"><titleInfo><title>Endocrinology</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>143</number></detail><extent unit="pages"><start>1225</start><end>1234</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Respiratory syncytial virus‐induced chemokine production: Linking viral replication to chemokine production in vitro and in vivo</title></titleInfo><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Miller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TL</namePart><namePart type="family">Bowlin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NW</namePart><namePart type="family">Lukacs</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Miller AL, Bowlin TL, Lukacs NW. 2004. Respiratory syncytial virus‐induced chemokine production: Linking viral replication to chemokine production in vitro and in vivo. J Infect Dis 189: 1419–1430.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>189</number></detail><extent unit="pages"><start>1419</start><end>1430</end></extent></part><relatedItem type="host"><titleInfo><title>J Infect Dis</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>189</number></detail><extent unit="pages"><start>1419</start><end>1430</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Inflammatory cytokine profile in children with severe acute respiratory syndrome</title></titleInfo><name type="personal"><namePart type="given">PC</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CWK</namePart><namePart type="family">Lam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CK</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FWT</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TF</namePart><namePart type="family">Leung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EKL</namePart><namePart type="family">Hon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HIS</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CK</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KSC</namePart><namePart type="family">Fung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TF</namePart><namePart type="family">Fok</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ng PC, Lam CWK, Li AM, Wong CK, Cheng FWT, Leung TF, Hon EKL, Chan HIS, Li CK, Fung KSC, Fok TF. 2004. Inflammatory cytokine profile in children with severe acute respiratory syndrome. Pediatrics 113: e7–e14.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><extent unit="pages"><start>e7</start><end>e14</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatrics</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><extent unit="pages"><start>e7</start><end>e14</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Lung pathology of fatal severe acute respiratory syndrome</title></titleInfo><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Nicholls</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LLM</namePart><namePart type="family">Poon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KC</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WF</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ST</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Leung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Chu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PK</namePart><namePart type="family">Hui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KL</namePart><namePart type="family">Mak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KW</namePart><namePart type="family">Yan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NC</namePart><namePart type="family">Tsang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KY</namePart><namePart type="family">Yuen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JSM</namePart><namePart type="family">Peiris</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nicholls JM, Poon LLM, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY, Peiris JSM. 2003. Lung pathology of fatal severe acute respiratory syndrome. Lancet 361: 1773–1778.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1773</start><end>1778</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1773</start><end>1778</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Dynamic changes in blood cytokine levels as clinical indicators in severe acute respiratory syndrome</title></titleInfo><name type="personal"><namePart type="given">BS</namePart><namePart type="family">Pang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LM</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ZH</namePart><namePart type="family">Tong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LL</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XX</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WJ</namePart><namePart type="family">Guo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Zhu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pang BS, Wang Z, Zhang LM, Tong ZH, Xu LL, Huang XX, Guo WJ, Zhu M, Wang C. 2003. Dynamic changes in blood cytokine levels as clinical indicators in severe acute respiratory syndrome. Chin Med J 116: 1283–1287.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>116</number></detail><extent unit="pages"><start>1283</start><end>1287</end></extent></part><relatedItem type="host"><titleInfo><title>Chin Med J</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>116</number></detail><extent unit="pages"><start>1283</start><end>1287</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Coronavirus as a possible cause of severe acute respiratory syndrome</title></titleInfo><name type="personal"><namePart type="given">JSM</namePart><namePart type="family">Peiris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ST</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LLM</namePart><namePart type="family">Poon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LYC</namePart><namePart type="family">Yam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Nicholls</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WKS</namePart><namePart type="family">Yee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WW</namePart><namePart type="family">Yan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MT</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VCC</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DNC</namePart><namePart type="family">Tsang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RWH</namePart><namePart type="family">Yung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TK</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KY</namePart><namePart type="family">Yuen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Peiris JSM, Lai ST, Poon LLM, Guan Y, Yam LYC, Lim W, Nicholls J, Yee WKS, Yan WW, Cheng MT, Cheng VCC, Chan KH, Tsang DNC, Yung RWH, Ng TK, Yuen KY. 2003a. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361: 1319–1325.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1319</start><end>1325</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1319</start><end>1325</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Clinical progression and viral load in a community outbreak of coronavirus‐associated SARS pneumonia: A prospective study</title></titleInfo><name type="personal"><namePart type="given">JSM</namePart><namePart type="family">Peiris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Chu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VCC</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KS</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IFN</namePart><namePart type="family">Hung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LLM</namePart><namePart type="family">Poon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KI</namePart><namePart type="family">Law</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BSF</namePart><namePart type="family">Tang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TYW</namePart><namePart type="family">Hon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CS</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JSC</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BJ</namePart><namePart type="family">Zheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WL</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RWM</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KY</namePart><namePart type="family">Yuen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Peiris JSM, Chu CM, Cheng VCC, Chan KS, Hung IFN, Poon LLM, Law KI, Tang BSF, Hon TYW, Chan CS, Chan KH, Ng JSC, Zheng BJ, Ng WL, Lai RWM, Guan Y, Yuen KY. 2003b. Clinical progression and viral load in a community outbreak of coronavirus‐associated SARS pneumonia: A prospective study. Lancet 361: 1767–1772.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1767</start><end>1772</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1767</start><end>1772</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Development of a standard treatment protocol for severe acute respiratory syndrome</title></titleInfo><name type="personal"><namePart type="given">LKY</namePart><namePart type="family">So</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ACW</namePart><namePart type="family">Lau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LYC</namePart><namePart type="family">Yam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TMT</namePart><namePart type="family">Cheung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Poon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RWH</namePart><namePart type="family">Yung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KY</namePart><namePart type="family">Yuen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">So LKY, Lau ACW, Yam LYC, Cheung TMT, Poon E, Yung RWH, Yuen KY. 2003. Development of a standard treatment protocol for severe acute respiratory syndrome. Lancet 361: 1615–1617.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1615</start><end>1617</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1615</start><end>1617</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Antigen‐induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon‐gamma and is independent of perforin and granzymes</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Sobek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Balkow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Korner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MM</namePart><namePart type="family">Simon</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sobek V, Balkow S, Korner H, Simon MM. 2002. Antigen‐induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon‐gamma and is independent of perforin and granzymes. Eur J Immunol 32: 2490–2499.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>2490</start><end>2499</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>2490</start><end>2499</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Inhibition of SARS Coronavirus infection in vitro with clinically approved antiviral drugs</title></titleInfo><name type="personal"><namePart type="given">ELC</namePart><namePart type="family">Tan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EE</namePart><namePart type="family">Ooi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HC</namePart><namePart type="family">Tan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AE</namePart><namePart type="family">Ling</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LW</namePart><namePart type="family">Stanton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tan ELC, Ooi EE, Lin CY, Tan HC, Ling AE, Lim B, Stanton LW. 2004. Inhibition of SARS Coronavirus infection in vitro with clinically approved antiviral drugs. Emerg Infect Dis 10: 581–586.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>581</start><end>586</end></extent></part><relatedItem type="host"><titleInfo><title>Emerg Infect Dis</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>581</start><end>586</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: The roles of cytokines and cellular immune activation in patients with pulmonary edema</title></titleInfo><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HY</namePart><namePart type="family">Lei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KJ</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CK</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IJ</namePart><namePart type="family">Su</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wang SM, Lei HY, Huang KJ, Wu JM, Wang JR, Yu CK, Su IJ, Liu CC. 2003. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: The roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis 188: 564–570.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>564</start><end>570</end></extent></part><relatedItem type="host"><titleInfo><title>J Infect Dis</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>564</start><end>570</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN‐γ and Fas</title></titleInfo><name type="personal"><namePart type="given">LP</namePart><namePart type="family">Wen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Madani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Fahrni</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Duncan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GD</namePart><namePart type="family">Rosen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wen LP, Madani K, Fahrni JA, Duncan SR, Rosen GD. 1997. Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN‐γ and Fas. Am J Physiol 273: L921–L929.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>273</number></detail><extent unit="pages"><start>L921</start><end>L929</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Physiol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>273</number></detail><extent unit="pages"><start>L921</start><end>L929</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Plasma inflammatory cytokines and chemokines in severe respiratory syndrome</title></titleInfo><name type="personal"><namePart type="given">CK</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CWK</namePart><namePart type="family">Lam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AKL</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Ip</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NLS</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IHS</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LCW</namePart><namePart type="family">Lit</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DSC</namePart><namePart type="family">Hui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MHM</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SSC</namePart><namePart type="family">Chung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JJY</namePart><namePart type="family">Sung</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wong CK, Lam CWK, Wu AKL, Ip WK, Lee NLS, Chan IHS, Lit LCW, Hui DSC, Chan MHM, Chung SSC, Sung JJY. 2004. Plasma inflammatory cytokines and chemokines in severe respiratory syndrome. Clin Exp Immunol 136: 95–103.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>95</start><end>103</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Exp Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>95</start><end>103</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Serologic and molecular biologic methods for SARS‐associated coronavirus infection, Taiwan</title></titleInfo><name type="personal"><namePart type="given">HS</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Chiu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TC</namePart><namePart type="family">Tseng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ZF</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YF</namePart><namePart type="family">Hsu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TL</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WZ</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TL</namePart><namePart type="family">Ferng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LC</namePart><namePart type="family">Hsu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LL</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HY</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SP</namePart><namePart type="family">Su</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SY</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TH</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IJ</namePart><namePart type="family">Su</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wu HS, Chiu SC, Tseng TC, Lin ZF, Lin JH, Hsu YF, Wang MC, Lin TL, Yang WZ, Ferng TL, Huang KH, Hsu LC, Lee LL, Yang JY, Chen HY, Su SP, Yang SY, Lin TH, Su IJ. 2004a. Serologic and molecular biologic methods for SARS‐associated coronavirus infection, Taiwan. Emerg Infect Dis 10: 304–310.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>304</start><end>310</end></extent></part><relatedItem type="host"><titleInfo><title>Emerg Infect Dis</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>304</start><end>310</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Early detection of antibodies against various structural proteins of the SARS‐associated Coronavirus in SARS patients</title></titleInfo><name type="personal"><namePart type="given">HS</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YC</namePart><namePart type="family">Hsieh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IJ</namePart><namePart type="family">Su</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TH</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Chiu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YF</namePart><namePart type="family">Hsu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PW</namePart><namePart type="family">Hsiao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GD</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AHJ</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HW</namePart><namePart type="family">Ting</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Chou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CJ</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wu HS, Hsieh YC, Su IJ, Lin TH, Chiu SC, Hsu YF, Lin JH, Wang MC, Chen JY, Hsiao PW, Chang GD, Wang AHJ, Ting HW, Chou CM, Huang CJ. 2004b. Early detection of antibodies against various structural proteins of the SARS‐associated Coronavirus in SARS patients. J Biomed Sci 11: 117–126.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>117</start><end>126</end></extent></part><relatedItem type="host"><titleInfo><title>J Biomed Sci</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>117</start><end>126</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Analysis of serum cytokines in patients with severe acute respiratory syndrome</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Ye</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Sun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Lou</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Zhang Y, Li J, Zhan Y, Wu L, Yu X, Zhang W, Ye L, Xu S, Sun R, Wang Y, Lou J. 2004. Analysis of serum cytokines in patients with severe acute respiratory syndrome. Infect Immun 72: 4410–4415.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>4410</start><end>4415</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Immun</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>4410</start><end>4415</end></extent></part></relatedItem></relatedItem><identifier type="istex">7E668DE065E11CC43E91DAB2D3B9C67B607090C0</identifier><identifier type="ark">ark:/67375/WNG-G7Z3D7ZD-8</identifier><identifier type="DOI">10.1002/jmv.20255</identifier><identifier type="ArticleID">JMV20255</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2004 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-G7Z3D7ZD-8/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000313 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000313 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:7E668DE065E11CC43E91DAB2D3B9C67B607090C0
|texte= An interferon‐γ‐related cytokine storm in SARS patients
}}
| This area was generated with Dilib version V0.6.33. |  |