SrasV1, Main, Merge, bibRecord, 005229

An interferon-γ-related cytokine storm in SARS patients

Identifieur interne : 005229 ( Main/Merge ); précédent : 005228; suivant : 005230

An interferon-γ-related cytokine storm in SARS patients

Auteurs : Kao-Jean Huang [Taïwan] ; Ih-Jen Su [Taïwan] ; Michel Theron [Taïwan] ; Yi-Chun Wu [Taïwan] ; Shu-Kuan Lai [Taïwan] ; Ching-Chuan Liu [Taïwan] ; Huan-Yao Lei [Taïwan]

Source :

Journal of medical virology [ 0146-6615 ] ; 2005.

RBID : Pascal:05-0459051

Descripteurs français

Pascal (Inist)
- Homme, Enterovirus, Interféron gamma, Cytokine, Oedème, Fièvre hémorragique, Hémorragie, Syndrome respiratoire aigu sévère, Dengue hémorragique.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cytokine, Dengue hemorrhagic fever, Edema, Enterovirus, Gamma interferon, Hemorrhage, Hemorrhagic fever, Human, Severe acute respiratory syndrome.

Abstract

Fourteen cytokines or chemokines were analyzed on 88 RT-PCR-confirmed severe acute respiratory syndrome (SARS) patients. IFN-y, IL-18, TGF-β, IL-6, IP-10, MCP-1, MIG, and IL-8, but not ofTNF-a, IL-2, IL-4, IL-10, IL-13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN-y was significantly higher in the Ab(+) group than in the Ab(-) group. IFN-y, IL-18, MCP-1, MIG, and IP-10 were already elevated at early days post fever onset. Furthermore, levels of IL-18, IP-10, MIG, and MCP-1 were significantly higher in the death group than in the survival group. For the survival group, IFN-y and MCP-1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon-γ-related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients.

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Pascal:05-0459051

Le document en format XML

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<front><div type="abstract" xml:lang="en">Fourteen cytokines or chemokines were analyzed on 88 RT-PCR-confirmed severe acute respiratory syndrome (SARS) patients. IFN-y, IL-18, TGF-β, IL-6, IP-10, MCP-1, MIG, and IL-8, but not ofTNF-a, IL-2, IL-4, IL-10, IL-13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN-y was significantly higher in the Ab(+) group than in the Ab(-) group. IFN-y, IL-18, MCP-1, MIG, and IP-10 were already elevated at early days post fever onset. Furthermore, levels of IL-18, IP-10, MIG, and MCP-1 were significantly higher in the death group than in the survival group. For the survival group, IFN-y and MCP-1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon-γ-related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients.</div>
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An interferon-γ-related cytokine storm in SARS patients

An interferon-γ-related cytokine storm in SARS patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri