Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus
Identifieur interne : 003E98 ( Main/Exploration ); précédent : 003E97; suivant : 003E99Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus
Auteurs : Pui Ying Peggy Law ; Yuet-Man Liu ; Hua Geng ; Ka Ho Kwan ; Mary Miu-Yee Waye ; Yuan-Yuan HoSource :
- Febs Letters [ 0014-5793 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : ADN.
- génétique : Gènes rapporteurs, Protéines virales, Thymidine, Virus du SRAS.
- métabolisme : Protéines virales, Virus du SRAS.
- Animaux, Cricetinae, Expression des gènes, Lignée cellulaire, Régulation de l'expression des gènes viraux.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : DNA.
- genetics : Genes, Reporter, SARS Virus, Thymidine, Viral Proteins.
- metabolism : SARS Virus, Viral Proteins.
- Animals, Cell Line, Chlorocebus aethiops, Cricetinae, Gene Expression, Gene Expression Regulation, Viral.
Abstract
SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.
Url:
DOI: 10.1016/j.febslet.2006.05.051
PubMed: 16753150
PubMed Central: 7094570
Affiliations:
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Le document en format XML
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<term>DNA (biosynthesis)</term>
<term>Gene Expression</term>
<term>Gene Expression Regulation, Viral</term>
<term>Genes, Reporter (genetics)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (metabolism)</term>
<term>Thymidine (genetics)</term>
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<term>Lignée cellulaire</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (métabolisme)</term>
<term>Régulation de l'expression des gènes viraux</term>
<term>Thymidine (génétique)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (métabolisme)</term>
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<front><div type="abstract" xml:lang="en"><p>SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.</p>
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<tree><noCountry><name sortKey="Geng, Hua" sort="Geng, Hua" uniqKey="Geng H" first="Hua" last="Geng">Hua Geng</name>
<name sortKey="Ho, Yuan Yuan" sort="Ho, Yuan Yuan" uniqKey="Ho Y" first="Yuan-Yuan" last="Ho">Yuan-Yuan Ho</name>
<name sortKey="Kwan, Ka Ho" sort="Kwan, Ka Ho" uniqKey="Kwan K" first="Ka Ho" last="Kwan">Ka Ho Kwan</name>
<name sortKey="Law, Pui Ying Peggy" sort="Law, Pui Ying Peggy" uniqKey="Law P" first="Pui Ying Peggy" last="Law">Pui Ying Peggy Law</name>
<name sortKey="Liu, Yuet Man" sort="Liu, Yuet Man" uniqKey="Liu Y" first="Yuet-Man" last="Liu">Yuet-Man Liu</name>
<name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name>
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