SrasV1, Main, Curation, bibRecord, 003E98

Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus

Identifieur interne : 003E98 ( Main/Curation ); précédent : 003E97; suivant : 003E99

Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus

Auteurs : Pui Ying Peggy Law ; Yuet-Man Liu ; Hua Geng ; Ka Ho Kwan ; Mary Miu-Yee Waye ; Yuan-Yuan Ho

Source :

Febs Letters [ 0014-5793 ] ; 2006.

RBID : PMC:7094570

Descripteurs français

KwdFr :
- ADN (biosynthèse), Animaux, Cricetinae, Expression des gènes, Gènes rapporteurs (génétique), Lignée cellulaire, Protéines virales (génétique), Protéines virales (métabolisme), Régulation de l'expression des gènes viraux, Thymidine (génétique), Virus du SRAS (génétique), Virus du SRAS (métabolisme).
MESH :
- biosynthèse : ADN.
- génétique : Gènes rapporteurs, Protéines virales, Thymidine, Virus du SRAS.
- métabolisme : Protéines virales, Virus du SRAS.
- Animaux, Cricetinae, Expression des gènes, Lignée cellulaire, Régulation de l'expression des gènes viraux.

English descriptors

KwdEn :
- Animals, Cell Line, Chlorocebus aethiops, Cricetinae, DNA (biosynthesis), Gene Expression, Gene Expression Regulation, Viral, Genes, Reporter (genetics), SARS Virus (genetics), SARS Virus (metabolism), Thymidine (genetics), Viral Proteins (genetics), Viral Proteins (metabolism).
MESH :
- chemical , biosynthesis : DNA.
- genetics : Genes, Reporter, SARS Virus, Thymidine, Viral Proteins.
- metabolism : SARS Virus, Viral Proteins.
- Animals, Cell Line, Chlorocebus aethiops, Cricetinae, Gene Expression, Gene Expression Regulation, Viral.

Abstract

SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094570

DOI: 10.1016/j.febslet.2006.05.051
PubMed: 16753150
PubMed Central: 7094570

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PMC:7094570

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<front><div type="abstract" xml:lang="en"><p>SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.</p>
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Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus

Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki