Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus
Identifieur interne : 001131 ( Pmc/Checkpoint ); précédent : 001130; suivant : 001132Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus
Auteurs : Pui Ying Peggy Law ; Yuet-Man Liu ; Hua Geng ; Ka Ho Kwan ; Mary Miu-Yee Waye ; Yuan-Yuan HoSource :
- Febs Letters [ 0014-5793 ] ; 2006.
Abstract
SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.
Url:
DOI: 10.1016/j.febslet.2006.05.051
PubMed: 16753150
PubMed Central: 7094570
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In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">FEBS Lett</journal-id><journal-id journal-id-type="iso-abbrev">FEBS Lett</journal-id><journal-id journal-id-type="doi">10.1002/(ISSN)1873-3468</journal-id><journal-id journal-id-type="publisher-id">FEB2</journal-id><journal-title-group><journal-title>Febs Letters</journal-title></journal-title-group><issn pub-type="ppub">0014-5793</issn><issn pub-type="epub">1873-3468</issn><publisher><publisher-name>John Wiley and Sons Inc.</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16753150</article-id><article-id pub-id-type="pmc">7094570</article-id><article-id pub-id-type="doi">10.1016/j.febslet.2006.05.051</article-id><article-id pub-id-type="publisher-id">FEB2S0014579306006648</article-id><article-categories><subj-group subj-group-type="overline"><subject>Short Communication</subject></subj-group><subj-group subj-group-type="heading"><subject>Short Communications</subject></subj-group></article-categories><title-group><article-title>Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus</article-title></title-group><contrib-group><contrib id="feb2s0014579306006648-cr-0001" contrib-type="author"><name><surname>Law</surname><given-names>Pui Ying Peggy</given-names></name><xref ref-type="aff" rid="feb2s0014579306006648-aff-aff1"><sup>1</sup></xref></contrib><contrib id="feb2s0014579306006648-cr-0002" contrib-type="author"><name><surname>Liu</surname><given-names>Yuet-Man</given-names></name><xref ref-type="aff" rid="feb2s0014579306006648-aff-aff1"><sup>1</sup></xref></contrib><contrib id="feb2s0014579306006648-cr-0003" contrib-type="author"><name><surname>Geng</surname><given-names>Hua</given-names></name><xref ref-type="aff" rid="feb2s0014579306006648-aff-aff1"><sup>1</sup></xref></contrib><contrib id="feb2s0014579306006648-cr-0004" contrib-type="author"><name><surname>Kwan</surname><given-names>Ka Ho</given-names></name><xref ref-type="aff" rid="feb2s0014579306006648-aff-aff2"><sup>2</sup></xref></contrib><contrib id="feb2s0014579306006648-cr-0005" contrib-type="author"><name><surname>Waye</surname><given-names>Mary Miu-Yee</given-names></name><xref ref-type="aff" rid="feb2s0014579306006648-aff-aff1"><sup>1</sup></xref><xref ref-type="aff" rid="feb2s0014579306006648-aff-aff3"><sup>3</sup></xref></contrib><contrib id="feb2s0014579306006648-cr-0006" contrib-type="author" corresp="yes"><name><surname>Ho</surname><given-names>Yuan-Yuan</given-names></name><xref ref-type="aff" rid="feb2s0014579306006648-aff-aff1"><sup>1</sup></xref><address><email>yuanyuanho@cuhk.edu.hk</email></address></contrib></contrib-group><aff id="feb2s0014579306006648-aff-aff1"><label><sup>1</sup></label>The Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China</aff><aff id="feb2s0014579306006648-aff-aff2"><label><sup>2</sup></label>The Molecular Biotechnology Program, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China</aff><aff id="feb2s0014579306006648-aff-aff3"><label><sup>3</sup></label>Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China</aff><author-notes><corresp id="correspondenceTo"><label>*</label>Corresponding author. Fax: +852 2603 7732.</corresp></author-notes><pub-date pub-type="ppub"><day>26</day><month>6</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>02</day><month>6</month><year>2006</year></pub-date><volume>580</volume><issue>15</issue><issue-id pub-id-type="doi">10.1002/feb2.2006.580.issue-15</issue-id><fpage>3643</fpage><lpage>3648</lpage><history><date date-type="received"><day>06</day><month>5</month><year>2006</year></date><date date-type="accepted"><day>19</day><month>5</month><year>2006</year></date></history><permissions><pmc-comment> © 2015 Federation of European Biochemical Societies </pmc-comment>
<copyright-statement content-type="article-copyright">FEBS Letters 580 (2006) 1873-3468 © 2015 Federation of European Biochemical Societies</copyright-statement><license><license-p>This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="file:FEB2-580-3643.pdf"></self-uri><abstract><p>SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.</p></abstract><kwd-group><kwd id="feb2s0014579306006648-kwd-0001">Severe acute respiratory syndrome</kwd><kwd id="feb2s0014579306006648-kwd-0002">Coronavirus</kwd><kwd id="feb2s0014579306006648-kwd-0003">SARS ORF 8</kwd><kwd id="feb2s0014579306006648-kwd-0004">SARS 8b</kwd><kwd id="feb2s0014579306006648-kwd-0005">X5</kwd></kwd-group><counts><page-count count="6"></page-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>June 26, 2006</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.0 mode:remove_FC converted:15.04.2020</meta-value></custom-meta></custom-meta-group></article-meta><notes><p content-type="self-citation"><mixed-citation publication-type="journal" id="feb2s0014579306006648-cit-0000"><string-name><surname>Law</surname><given-names>Pui Ying Peggy</given-names></string-name>,<string-name><surname>Liu</surname><given-names>Yuet-Man</given-names></string-name>,<string-name><surname>Geng</surname><given-names>Hua</given-names></string-name>,<string-name><surname>Kwan</surname><given-names>Ka Ho</given-names></string-name>,<string-name><surname>Waye</surname><given-names>Mary Miu-Yee</given-names></string-name> and <string-name><surname>Ho</surname><given-names>Yuan-Yuan</given-names></string-name>(<year>2006</year>), <article-title>Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome-associated coronavirus</article-title>, <source xml:lang="en">FEBS Letters</source>, <volume>580</volume>, doi: 10.1016/j.febslet.2006.05.051</mixed-citation></p></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Geng, Hua" sort="Geng, Hua" uniqKey="Geng H" first="Hua" last="Geng">Hua Geng</name><name sortKey="Ho, Yuan Yuan" sort="Ho, Yuan Yuan" uniqKey="Ho Y" first="Yuan-Yuan" last="Ho">Yuan-Yuan Ho</name><name sortKey="Kwan, Ka Ho" sort="Kwan, Ka Ho" uniqKey="Kwan K" first="Ka Ho" last="Kwan">Ka Ho Kwan</name><name sortKey="Law, Pui Ying Peggy" sort="Law, Pui Ying Peggy" uniqKey="Law P" first="Pui Ying Peggy" last="Law">Pui Ying Peggy Law</name><name sortKey="Liu, Yuet Man" sort="Liu, Yuet Man" uniqKey="Liu Y" first="Yuet-Man" last="Liu">Yuet-Man Liu</name><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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