Differential characteristics of the early stage of lung inflammation induced by SARS-CoV Nucleocapsid protein related to age in the mouse
Identifieur interne : 002E24 ( Main/Exploration ); précédent : 002E23; suivant : 002E25Differential characteristics of the early stage of lung inflammation induced by SARS-CoV Nucleocapsid protein related to age in the mouse
Auteurs : Y. G. Zhu [République populaire de Chine] ; J. M. Qu [République populaire de Chine]Source :
- Inflammation Research [ 1023-3830 ] ; 2009-06-01.
Descripteurs français
- KwdFr :
- Animaux, Chimiokines (immunologie), Cytokines (immunologie), Mâle, Oedème pulmonaire (anatomopathologie), Oedème pulmonaire (immunologie), Pneumopathie infectieuse (anatomopathologie), Pneumopathie infectieuse (immunologie), Poumon (anatomopathologie), Poumon (immunologie), Protéines nucléocapside (immunologie), Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (immunologie), Vieillissement (immunologie), Virus du SRAS (immunologie).
- MESH :
- anatomopathologie : Oedème pulmonaire, Pneumopathie infectieuse, Poumon, Syndrome respiratoire aigu sévère.
- immunologie : Chimiokines, Cytokines, Oedème pulmonaire, Pneumopathie infectieuse, Poumon, Protéines nucléocapside, Syndrome respiratoire aigu sévère, Vieillissement, Virus du SRAS.
- Animaux, Mâle, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Age, Aging (immunology), Animals, Chemokines (immunology), Cytokines (immunology), IFN-γ, Lung (immunology), Lung (pathology), Male, Mice, Mice, Inbred BALB C, N-protein of SARS-CoV, Nucleocapsid Proteins (immunology), Pneumonia (immunology), Pneumonia (pathology), Pulmonary Edema (immunology), Pulmonary Edema (pathology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (pathology), Severe acute respiratory syndrome (SARS), TNF-α.
- MESH :
- chemical , immunology : Chemokines, Cytokines, Nucleocapsid Proteins.
- immunology : Aging, Lung, Pneumonia, Pulmonary Edema, SARS Virus, Severe Acute Respiratory Syndrome.
- pathology : Lung, Pneumonia, Pulmonary Edema, Severe Acute Respiratory Syndrome.
- Animals, Male, Mice, Mice, Inbred BALB C.
Abstract
Abstract.: Objective:: Severe acute respiratory syndrome (SARS) is an acute infectious disease of the respiratory system which has newly emerged. Interestingly, it appears to be a disease that predominantly affects adults while the mortality in children is extremely low. However, the pathogenesis of SARS in relation to different characteristics relevant to age remains unclear. Material and Methods:: To better understand the role of cytokines in the immunopathological processes of SARS, weanling (4 weeks old), young (6 weeks old) and adult (10 weeks old) male BALB/C mice were inoculated intranasally with N-protein of SARS-CoV in this study. Serum or lung homogenate levels of some cytokines such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) along with acute injury lung index and histology were also analyzed. Results:: Histopathological analysis of adult male BALB/C mice after N-protein infection showed progressive inflammatory reactions, especially pulmonary edema, in accordance with a moderately (~13%) elevated level of W/D ratio at 24 h. Although adult groups underwent a progressive lung inflammation in the acute phase accompanied by raised levels of TNF-α in serum, no significant changes in lung TNF-α level were reported simultaneously. Moreover, adult SARS infected BALB/c mice showed elevated levels of IFN-γ while IFN-γ levels in weanling and young groups had no obvious association with lung inflammation. Conclusion:: Our study supports the observation that adult mice do have progressively greater immune reactions than weanling and adolescent ones over time. The relative immaturity of the immune system in weanlings may confer benefit leading to less impairment of lung function. However, the measurement of TNF-α and IFN-γ levels was not indicative of the severity of lung injury at the early stage of disease.
Url:
DOI: 10.1007/s00011-009-8062-9
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000331
- to stream Istex, to step Curation: 000331
- to stream Istex, to step Checkpoint: 000D87
- to stream PubMed, to step Corpus: 001955
- to stream PubMed, to step Curation: 001955
- to stream PubMed, to step Checkpoint: 001897
- to stream Ncbi, to step Merge: 001E55
- to stream Ncbi, to step Curation: 001E55
- to stream Ncbi, to step Checkpoint: 001E55
- to stream Main, to step Merge: 002E78
- to stream Main, to step Curation: 002E24
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential characteristics of the early stage of lung inflammation induced by SARS-CoV Nucleocapsid protein related to age in the mouse</title>
<author><name sortKey="Zhu, Y G" sort="Zhu, Y G" uniqKey="Zhu Y" first="Y. G." last="Zhu">Y. G. Zhu</name>
</author>
<author><name sortKey="Qu, J M" sort="Qu, J M" uniqKey="Qu J" first="J. M." last="Qu">J. M. Qu</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9939A964B9CDB0070DBDF48EB4340E261742720B</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1007/s00011-009-8062-9</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-HJC6FHF4-J/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000331</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000331</idno>
<idno type="wicri:Area/Istex/Curation">000331</idno>
<idno type="wicri:Area/Istex/Checkpoint">000D87</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000D87</idno>
<idno type="wicri:doubleKey">1023-3830:2009:Zhu Y:differential:characteristics:of</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19234811</idno>
<idno type="wicri:Area/PubMed/Corpus">001955</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001955</idno>
<idno type="wicri:Area/PubMed/Curation">001955</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001955</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001897</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001897</idno>
<idno type="wicri:Area/Ncbi/Merge">001E55</idno>
<idno type="wicri:Area/Ncbi/Curation">001E55</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001E55</idno>
<idno type="wicri:Area/Main/Merge">002E78</idno>
<idno type="wicri:Area/Main/Curation">002E24</idno>
<idno type="wicri:Area/Main/Exploration">002E24</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Differential characteristics of the early stage of lung inflammation induced by SARS-CoV Nucleocapsid protein related to age in the mouse</title>
<author><name sortKey="Zhu, Y G" sort="Zhu, Y G" uniqKey="Zhu Y" first="Y. G." last="Zhu">Y. G. Zhu</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary Medicine, Huadong Hospital, 200040, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Medical School of Fudan University, 200032, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qu, J M" sort="Qu, J M" uniqKey="Qu J" first="J. M." last="Qu">J. M. Qu</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary Medicine, Huadong Hospital, 200040, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Medical School of Fudan University, 200032, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Inflammation Research</title>
<title level="j" type="sub">Official Journal of: The International Association of Inflammation Societies The European Histamine Research Society</title>
<title level="j" type="abbrev">Inflamm. Res.</title>
<idno type="ISSN">1023-3830</idno>
<idno type="eISSN">1420-908X</idno>
<imprint><publisher>Birkhäuser-Verlag; www.birkhäuser.ch</publisher>
<pubPlace>Basel</pubPlace>
<date type="published" when="2009-06-01">2009-06-01</date>
<biblScope unit="volume">58</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="312">312</biblScope>
<biblScope unit="page" to="320">320</biblScope>
</imprint>
<idno type="ISSN">1023-3830</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1023-3830</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term>
<term>Aging (immunology)</term>
<term>Animals</term>
<term>Chemokines (immunology)</term>
<term>Cytokines (immunology)</term>
<term>IFN-γ</term>
<term>Lung (immunology)</term>
<term>Lung (pathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>N-protein of SARS-CoV</term>
<term>Nucleocapsid Proteins (immunology)</term>
<term>Pneumonia (immunology)</term>
<term>Pneumonia (pathology)</term>
<term>Pulmonary Edema (immunology)</term>
<term>Pulmonary Edema (pathology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe acute respiratory syndrome (SARS)</term>
<term>TNF-α</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chimiokines (immunologie)</term>
<term>Cytokines (immunologie)</term>
<term>Mâle</term>
<term>Oedème pulmonaire (anatomopathologie)</term>
<term>Oedème pulmonaire (immunologie)</term>
<term>Pneumopathie infectieuse (anatomopathologie)</term>
<term>Pneumopathie infectieuse (immunologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (immunologie)</term>
<term>Protéines nucléocapside (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Vieillissement (immunologie)</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Chemokines</term>
<term>Cytokines</term>
<term>Nucleocapsid Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Oedème pulmonaire</term>
<term>Pneumopathie infectieuse</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Chimiokines</term>
<term>Cytokines</term>
<term>Oedème pulmonaire</term>
<term>Pneumopathie infectieuse</term>
<term>Poumon</term>
<term>Protéines nucléocapside</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Vieillissement</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aging</term>
<term>Lung</term>
<term>Pneumonia</term>
<term>Pulmonary Edema</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
<term>Pneumonia</term>
<term>Pulmonary Edema</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract.: Objective:: Severe acute respiratory syndrome (SARS) is an acute infectious disease of the respiratory system which has newly emerged. Interestingly, it appears to be a disease that predominantly affects adults while the mortality in children is extremely low. However, the pathogenesis of SARS in relation to different characteristics relevant to age remains unclear. Material and Methods:: To better understand the role of cytokines in the immunopathological processes of SARS, weanling (4 weeks old), young (6 weeks old) and adult (10 weeks old) male BALB/C mice were inoculated intranasally with N-protein of SARS-CoV in this study. Serum or lung homogenate levels of some cytokines such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) along with acute injury lung index and histology were also analyzed. Results:: Histopathological analysis of adult male BALB/C mice after N-protein infection showed progressive inflammatory reactions, especially pulmonary edema, in accordance with a moderately (~13%) elevated level of W/D ratio at 24 h. Although adult groups underwent a progressive lung inflammation in the acute phase accompanied by raised levels of TNF-α in serum, no significant changes in lung TNF-α level were reported simultaneously. Moreover, adult SARS infected BALB/c mice showed elevated levels of IFN-γ while IFN-γ levels in weanling and young groups had no obvious association with lung inflammation. Conclusion:: Our study supports the observation that adult mice do have progressively greater immune reactions than weanling and adolescent ones over time. The relative immaturity of the immune system in weanlings may confer benefit leading to less impairment of lung function. However, the measurement of TNF-α and IFN-γ levels was not indicative of the severity of lung injury at the early stage of disease.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Y G" sort="Zhu, Y G" uniqKey="Zhu Y" first="Y. G." last="Zhu">Y. G. Zhu</name>
</noRegion>
<name sortKey="Qu, J M" sort="Qu, J M" uniqKey="Qu J" first="J. M." last="Qu">J. M. Qu</name>
<name sortKey="Qu, J M" sort="Qu, J M" uniqKey="Qu J" first="J. M." last="Qu">J. M. Qu</name>
<name sortKey="Qu, J M" sort="Qu, J M" uniqKey="Qu J" first="J. M." last="Qu">J. M. Qu</name>
<name sortKey="Zhu, Y G" sort="Zhu, Y G" uniqKey="Zhu Y" first="Y. G." last="Zhu">Y. G. Zhu</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E24 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002E24 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:9939A964B9CDB0070DBDF48EB4340E261742720B |texte= Differential characteristics of the early stage of lung inflammation induced by SARS-CoV Nucleocapsid protein related to age in the mouse }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |