Differential characteristics of the early stage of lung inflammation induced by SARS-CoV Nucleocapsid protein related to age in the mouse.
Identifieur interne : 001897 ( PubMed/Checkpoint ); précédent : 001896; suivant : 001898Differential characteristics of the early stage of lung inflammation induced by SARS-CoV Nucleocapsid protein related to age in the mouse.
Auteurs : Y G Zhu [République populaire de Chine] ; J M QuSource :
- Inflammation research : official journal of the European Histamine Research Society ... [et al.] [ 1420-908X ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Chimiokines (immunologie), Cytokines (immunologie), Mâle, Oedème pulmonaire (anatomopathologie), Oedème pulmonaire (immunologie), Pneumopathie infectieuse (anatomopathologie), Pneumopathie infectieuse (immunologie), Poumon (anatomopathologie), Poumon (immunologie), Protéines nucléocapside (immunologie), Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (immunologie), Vieillissement (immunologie), Virus du SRAS (immunologie).
- MESH :
- anatomopathologie : Oedème pulmonaire, Pneumopathie infectieuse, Poumon, Syndrome respiratoire aigu sévère.
- immunologie : Chimiokines, Cytokines, Oedème pulmonaire, Pneumopathie infectieuse, Poumon, Protéines nucléocapside, Syndrome respiratoire aigu sévère, Vieillissement, Virus du SRAS.
- Animaux, Mâle, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Aging (immunology), Animals, Chemokines (immunology), Cytokines (immunology), Lung (immunology), Lung (pathology), Male, Mice, Mice, Inbred BALB C, Nucleocapsid Proteins (immunology), Pneumonia (immunology), Pneumonia (pathology), Pulmonary Edema (immunology), Pulmonary Edema (pathology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (pathology).
- MESH :
- chemical , immunology : Chemokines, Cytokines, Nucleocapsid Proteins.
- immunology : Aging, Lung, Pneumonia, Pulmonary Edema, SARS Virus, Severe Acute Respiratory Syndrome.
- pathology : Lung, Pneumonia, Pulmonary Edema, Severe Acute Respiratory Syndrome.
- Animals, Male, Mice, Mice, Inbred BALB C.
Abstract
Severe acute respiratory syndrome (SARS) is an acute infectious disease of the respiratory system which has newly emerged. Interestingly, it appears to be a disease that predominantly affects adults while the mortality in children is extremely low. However, the pathogenesis of SARS in relation to different characteristics relevant to age remains unclear.
DOI: 10.1007/s00011-009-8062-9
PubMed: 19234811
Affiliations:
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pubmed:19234811Le document en format XML
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<author><name sortKey="Zhu, Y G" sort="Zhu, Y G" uniqKey="Zhu Y" first="Y G" last="Zhu">Y G Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary Medicine, Huadong Hospital, Shanghai, 200040, China.</nlm:affiliation>
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<wicri:regionArea>Department of Pulmonary Medicine, Huadong Hospital, Shanghai, 200040</wicri:regionArea>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (immunology)</term>
<term>Animals</term>
<term>Chemokines (immunology)</term>
<term>Cytokines (immunology)</term>
<term>Lung (immunology)</term>
<term>Lung (pathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Nucleocapsid Proteins (immunology)</term>
<term>Pneumonia (immunology)</term>
<term>Pneumonia (pathology)</term>
<term>Pulmonary Edema (immunology)</term>
<term>Pulmonary Edema (pathology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chimiokines (immunologie)</term>
<term>Cytokines (immunologie)</term>
<term>Mâle</term>
<term>Oedème pulmonaire (anatomopathologie)</term>
<term>Oedème pulmonaire (immunologie)</term>
<term>Pneumopathie infectieuse (anatomopathologie)</term>
<term>Pneumopathie infectieuse (immunologie)</term>
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<term>Poumon (immunologie)</term>
<term>Protéines nucléocapside (immunologie)</term>
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<term>Souris de lignée BALB C</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Vieillissement (immunologie)</term>
<term>Virus du SRAS (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Chemokines</term>
<term>Cytokines</term>
<term>Nucleocapsid Proteins</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Oedème pulmonaire</term>
<term>Pneumopathie infectieuse</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Chimiokines</term>
<term>Cytokines</term>
<term>Oedème pulmonaire</term>
<term>Pneumopathie infectieuse</term>
<term>Poumon</term>
<term>Protéines nucléocapside</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Vieillissement</term>
<term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aging</term>
<term>Lung</term>
<term>Pneumonia</term>
<term>Pulmonary Edema</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
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<term>Pneumonia</term>
<term>Pulmonary Edema</term>
<term>Severe Acute Respiratory Syndrome</term>
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<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Mâle</term>
<term>Souris</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an acute infectious disease of the respiratory system which has newly emerged. Interestingly, it appears to be a disease that predominantly affects adults while the mortality in children is extremely low. However, the pathogenesis of SARS in relation to different characteristics relevant to age remains unclear.</div>
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<DateCompleted><Year>2009</Year>
<Month>09</Month>
<Day>02</Day>
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<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>24</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1420-908X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>58</Volume>
<Issue>6</Issue>
<PubDate><Year>2009</Year>
<Month>Jun</Month>
</PubDate>
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<Title>Inflammation research : official journal of the European Histamine Research Society ... [et al.]</Title>
<ISOAbbreviation>Inflamm. Res.</ISOAbbreviation>
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<ArticleTitle>Differential characteristics of the early stage of lung inflammation induced by SARS-CoV Nucleocapsid protein related to age in the mouse.</ArticleTitle>
<Pagination><MedlinePgn>312-20</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00011-009-8062-9</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Severe acute respiratory syndrome (SARS) is an acute infectious disease of the respiratory system which has newly emerged. Interestingly, it appears to be a disease that predominantly affects adults while the mortality in children is extremely low. However, the pathogenesis of SARS in relation to different characteristics relevant to age remains unclear.</AbstractText>
<AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">To better understand the role of cytokines in the immunopathological processes of SARS, weanling (4 weeks old), young (6 weeks old) and adult (10 weeks old) male BALB/C mice were inoculated intranasally with N-protein of SARS-CoV in this study. Serum or lung homogenate levels of some cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) along with acute injury lung index and histology were also analyzed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Histopathological analysis of adult male BALB/C mice after N-protein infection showed progressive inflammatory reactions, especially pulmonary edema, in accordance with a moderately (approximately 13%) elevated level of W/D ratio at 24 h. Although adult groups underwent a progressive lung inflammation in the acute phase accompanied by raised levels of TNF-alpha in serum, no significant changes in lung TNF-alpha level were reported simultaneously. Moreover, adult SARS infected BALB/c mice showed elevated levels of IFN-gamma while IFN-gamma levels in weanling and young groups had no obvious association with lung inflammation.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our study supports the observation that adult mice do have progressively greater immune reactions than weanling and adolescent ones over time. The relative immaturity of the immune system in weanlings may confer benefit leading to less impairment of lung function. However, the measurement of TNF-alpha and IFN-gamma levels was not indicative of the severity of lung injury at the early stage of disease.</AbstractText>
</Abstract>
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<ForeName>Y G</ForeName>
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<AffiliationInfo><Affiliation>Department of Pulmonary Medicine, Huadong Hospital, Shanghai, 200040, China.</Affiliation>
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<Author ValidYN="Y"><LastName>Qu</LastName>
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<MeshHeading><DescriptorName UI="D011654" MajorTopicYN="N">Pulmonary Edema</DescriptorName>
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<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
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