SrasV1, Main, Curation, bibRecord, 005B25

Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets

Identifieur interne : 005B25 ( Main/Curation ); précédent : 005B24; suivant : 005B26

Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets

Auteurs : Hana Weingartl [Canada] ; Markus Czub [Canada] ; Stefanie Czub [Canada] ; James Neufeld [Canada] ; Peter Marszal [Canada] ; Jason Gren [Canada] ; Greg Smith [Canada] ; Shane Jones [Canada] ; Roxanne Proulx [Canada] ; Yvonne Deschambault [Canada] ; Elsie Grudeski [Canada] ; Anton Andonov [Canada] ; RUNTAO HE [Canada] ; YAN LI [Canada] ; John Copps [Canada] ; Allen Grolla [Canada] ; Daryl Dick [Canada] ; Jody Berry [Canada] ; Shelley Ganske [Canada] ; Lisa Manning [Canada] ; JINGXIN CAO [Canada]

Source :

Journal of virology [ 0022-538X ] ; 2004.

RBID : Pascal:05-0001530

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux (sang), Foie (anatomopathologie), Furets, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Hépatite (étiologie), Mâle, Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), RT-PCR, Vaccination, Vaccins antiviraux (effets indésirables), Vaccins synthétiques (effets indésirables), Virus de la vaccine (immunologie), Virus du SRAS (immunologie).
MESH :
- anatomopathologie : Foie.
- effets indésirables : Vaccins antiviraux, Vaccins synthétiques.
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- immunologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus de la vaccine, Virus du SRAS.
- sang : Anticorps antiviraux.
- étiologie : Hépatite.
Pascal (Inist)
- Animaux, Furets, Glycoprotéine de spicule des coronavirus, Mâle, RT-PCR, Vaccination, Virus vaccine, Immunisation, Vaccin, Vaccination, Vaccine, Virus recombinant, Prévention, Immunoprophylaxie, Grave, Syndrome respiratoire aigu sévère, Hépatite, Malade état grave, Aigu, Voie respiratoire, Furet, Forme grave.
Wicri :
- topic : Vaccin, Vaccination.

English descriptors

KwdEn :
- Acute, Animals, Antibodies, Viral (blood), Critically ill, Ferret, Ferrets, Hepatitis, Hepatitis (etiology), Immunization, Immunoprophylaxis, Liver (pathology), Male, Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Prevention, Recombinant virus, Respiratory tract, Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (immunology), Severe, Severe acute respiratory syndrome, Spike Glycoprotein, Coronavirus, Vaccination, Vaccine, Vaccines, Synthetic (adverse effects), Vaccinia, Vaccinia virus, Vaccinia virus (immunology), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Vaccines (adverse effects).
MESH :
- chemical , adverse effects : Vaccines, Synthetic, Viral Vaccines.
- chemical , blood : Antibodies, Viral.
- etiology : Hepatitis.
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , immunology : Membrane Glycoproteins, SARS Virus, Vaccinia virus, Viral Envelope Proteins.
- pathology : Liver.
- Animals, Ferrets, Male, Reverse Transcriptase Polymerase Chain Reaction, Spike Glycoprotein, Coronavirus, Vaccination.

Abstract

Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.

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Pascal:05-0001530

Le document en format XML

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<author><name sortKey="Yan Li" sort="Yan Li" uniqKey="Yan Li" last="Yan Li">YAN LI</name>
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 Canadian Science Centre for Human and Animal Health</s1>
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 Canadian Science Centre for Human and Animal Health</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets</title>
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<author><name sortKey="Czub, Markus" sort="Czub, Markus" uniqKey="Czub M" first="Markus" last="Czub">Markus Czub</name>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
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<author><name sortKey="Czub, Stefanie" sort="Czub, Stefanie" uniqKey="Czub S" first="Stefanie" last="Czub">Stefanie Czub</name>
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<author><name sortKey="Neufeld, James" sort="Neufeld, James" uniqKey="Neufeld J" first="James" last="Neufeld">James Neufeld</name>
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<author><name sortKey="Marszal, Peter" sort="Marszal, Peter" uniqKey="Marszal P" first="Peter" last="Marszal">Peter Marszal</name>
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<country>Canada</country>
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<author><name sortKey="Gren, Jason" sort="Gren, Jason" uniqKey="Gren J" first="Jason" last="Gren">Jason Gren</name>
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<author><name sortKey="Smith, Greg" sort="Smith, Greg" uniqKey="Smith G" first="Greg" last="Smith">Greg Smith</name>
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<author><name sortKey="Jones, Shane" sort="Jones, Shane" uniqKey="Jones S" first="Shane" last="Jones">Shane Jones</name>
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 Canadian Science Centre for Human and Animal Health</s1>
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<author><name sortKey="Proulx, Roxanne" sort="Proulx, Roxanne" uniqKey="Proulx R" first="Roxanne" last="Proulx">Roxanne Proulx</name>
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 Canadian Science Centre for Human and Animal Health</s1>
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<country>Canada</country>
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</affiliation>
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<author><name sortKey="Deschambault, Yvonne" sort="Deschambault, Yvonne" uniqKey="Deschambault Y" first="Yvonne" last="Deschambault">Yvonne Deschambault</name>
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 Canadian Science Centre for Human and Animal Health</s1>
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<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
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</author>
<author><name sortKey="Grudeski, Elsie" sort="Grudeski, Elsie" uniqKey="Grudeski E" first="Elsie" last="Grudeski">Elsie Grudeski</name>
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 Canadian Science Centre for Human and Animal Health</s1>
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<country>Canada</country>
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</affiliation>
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<author><name sortKey="Andonov, Anton" sort="Andonov, Anton" uniqKey="Andonov A" first="Anton" last="Andonov">Anton Andonov</name>
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 Canadian Science Centre for Human and Animal Health</s1>
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</affiliation>
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<author><name sortKey="Runtao He" sort="Runtao He" uniqKey="Runtao He" last="Runtao He">RUNTAO HE</name>
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<sZ>1 aut.</sZ>
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<country>Canada</country>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
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 Canadian Science Centre for Human and Animal Health</s1>
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<author><name sortKey="Grolla, Allen" sort="Grolla, Allen" uniqKey="Grolla A" first="Allen" last="Grolla">Allen Grolla</name>
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 Canadian Science Centre for Human and Animal Health</s1>
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<author><name sortKey="Dick, Daryl" sort="Dick, Daryl" uniqKey="Dick D" first="Daryl" last="Dick">Daryl Dick</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
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<author><name sortKey="Berry, Jody" sort="Berry, Jody" uniqKey="Berry J" first="Jody" last="Berry">Jody Berry</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
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<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
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<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1>
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<author><name sortKey="Ganske, Shelley" sort="Ganske, Shelley" uniqKey="Ganske S" first="Shelley" last="Ganske">Shelley Ganske</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
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<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
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<author><name sortKey="Manning, Lisa" sort="Manning, Lisa" uniqKey="Manning L" first="Lisa" last="Manning">Lisa Manning</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
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<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
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<author><name sortKey="Jingxin Cao" sort="Jingxin Cao" uniqKey="Jingxin Cao" last="Jingxin Cao">JINGXIN CAO</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1>
<s2>Winnipeg, Manitoba, R3T 2N2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<region type="state">Manitoba</region>
</placeName>
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 Canadian Science Centre for Human and Animal Health</s1>
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<sZ>2 aut.</sZ>
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<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Animals</term>
<term>Antibodies, Viral (blood)</term>
<term>Critically ill</term>
<term>Ferret</term>
<term>Ferrets</term>
<term>Hepatitis</term>
<term>Hepatitis (etiology)</term>
<term>Immunization</term>
<term>Immunoprophylaxis</term>
<term>Liver (pathology)</term>
<term>Male</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>Prevention</term>
<term>Recombinant virus</term>
<term>Respiratory tract</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>SARS Virus (immunology)</term>
<term>Severe</term>
<term>Severe acute respiratory syndrome</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccination</term>
<term>Vaccine</term>
<term>Vaccines, Synthetic (adverse effects)</term>
<term>Vaccinia</term>
<term>Vaccinia virus</term>
<term>Vaccinia virus (immunology)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Envelope Proteins (immunology)</term>
<term>Viral Vaccines (adverse effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Foie (anatomopathologie)</term>
<term>Furets</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Glycoprotéines membranaires (immunologie)</term>
<term>Hépatite (étiologie)</term>
<term>Mâle</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>RT-PCR</term>
<term>Vaccination</term>
<term>Vaccins antiviraux (effets indésirables)</term>
<term>Vaccins synthétiques (effets indésirables)</term>
<term>Virus de la vaccine (immunologie)</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Vaccines, Synthetic</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antiviraux</term>
<term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hepatitis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
<term>Virus de la vaccine</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>SARS Virus</term>
<term>Vaccinia virus</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hépatite</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Ferrets</term>
<term>Male</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Furets</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Mâle</term>
<term>RT-PCR</term>
<term>Vaccination</term>
<term>Virus vaccine</term>
<term>Immunisation</term>
<term>Vaccin</term>
<term>Vaccination</term>
<term>Vaccine</term>
<term>Virus recombinant</term>
<term>Prévention</term>
<term>Immunoprophylaxie</term>
<term>Grave</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Hépatite</term>
<term>Malade état grave</term>
<term>Aigu</term>
<term>Voie respiratoire</term>
<term>Furet</term>
<term>Forme grave</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
<term>Vaccination</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.</div>
</front>
</TEI>
<double idat="0022-538X:2004:Weingartl H:immunization:with:modified"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets</title>
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<s3>CAN</s3>
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 Canadian Science Centre for Human and Animal Health</s1>
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</author>
<author><name sortKey="Czub, Stefanie" sort="Czub, Stefanie" uniqKey="Czub S" first="Stefanie" last="Czub">Stefanie Czub</name>
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<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
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</author>
<author><name sortKey="Neufeld, James" sort="Neufeld, James" uniqKey="Neufeld J" first="James" last="Neufeld">James Neufeld</name>
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<s2>Winnipeg, Manitoba, R3E 3R2</s2>
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<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
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<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marszal, Peter" sort="Marszal, Peter" uniqKey="Marszal P" first="Peter" last="Marszal">Peter Marszal</name>
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<s2>Winnipeg, Manitoba, R3E 3R2</s2>
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<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gren, Jason" sort="Gren, Jason" uniqKey="Gren J" first="Jason" last="Gren">Jason Gren</name>
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<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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 Canadian Science Centre for Human and Animal Health</s1>
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 Canadian Science Centre for Human and Animal Health</s1>
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 Canadian Science Centre for Human and Animal Health</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets</title>
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 Canadian Science Centre for Human and Animal Health</s1>
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</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
<orgName type="university">Université du Manitoba</orgName>
</affiliation>
</author>
<author><name sortKey="Neufeld, James" sort="Neufeld, James" uniqKey="Neufeld J" first="James" last="Neufeld">James Neufeld</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marszal, Peter" sort="Marszal, Peter" uniqKey="Marszal P" first="Peter" last="Marszal">Peter Marszal</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
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<s3>CAN</s3>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gren, Jason" sort="Gren, Jason" uniqKey="Gren J" first="Jason" last="Gren">Jason Gren</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Greg" sort="Smith, Greg" uniqKey="Smith G" first="Greg" last="Smith">Greg Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jones, Shane" sort="Jones, Shane" uniqKey="Jones S" first="Shane" last="Jones">Shane Jones</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Proulx, Roxanne" sort="Proulx, Roxanne" uniqKey="Proulx R" first="Roxanne" last="Proulx">Roxanne Proulx</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deschambault, Yvonne" sort="Deschambault, Yvonne" uniqKey="Deschambault Y" first="Yvonne" last="Deschambault">Yvonne Deschambault</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grudeski, Elsie" sort="Grudeski, Elsie" uniqKey="Grudeski E" first="Elsie" last="Grudeski">Elsie Grudeski</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
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<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andonov, Anton" sort="Andonov, Anton" uniqKey="Andonov A" first="Anton" last="Andonov">Anton Andonov</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1>
<s2>Winnipeg, Manitoba, R3T 2N2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
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<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
<orgName type="university">Université du Manitoba</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Runtao He" sort="Runtao He" uniqKey="Runtao He" last="Runtao He">RUNTAO HE</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1>
<s2>Winnipeg, Manitoba, R3T 2N2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
<orgName type="university">Université du Manitoba</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yan Li" sort="Yan Li" uniqKey="Yan Li" last="Yan Li">YAN LI</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1>
<s2>Winnipeg, Manitoba, R3T 2N2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
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</placeName>
<orgName type="university">Université du Manitoba</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<sZ>20 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grolla, Allen" sort="Grolla, Allen" uniqKey="Grolla A" first="Allen" last="Grolla">Allen Grolla</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dick, Daryl" sort="Dick, Daryl" uniqKey="Dick D" first="Daryl" last="Dick">Daryl Dick</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berry, Jody" sort="Berry, Jody" uniqKey="Berry J" first="Jody" last="Berry">Jody Berry</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
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<sZ>20 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1>
<s2>Winnipeg, Manitoba, R3T 2N2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>21 aut.</sZ>
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<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
<orgName type="university">Université du Manitoba</orgName>
</affiliation>
</author>
<author><name sortKey="Ganske, Shelley" sort="Ganske, Shelley" uniqKey="Ganske S" first="Shelley" last="Ganske">Shelley Ganske</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manning, Lisa" sort="Manning, Lisa" uniqKey="Manning L" first="Lisa" last="Manning">Lisa Manning</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jingxin Cao" sort="Jingxin Cao" uniqKey="Jingxin Cao" last="Jingxin Cao">JINGXIN CAO</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1>
<s2>Winnipeg, Manitoba, R3T 2N2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
<orgName type="university">Université du Manitoba</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup>
 Canadian Science Centre for Human and Animal Health</s1>
<s2>Winnipeg, Manitoba, R3E 3R2</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Winnipeg, Manitoba, R3E 3R2</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Critically ill</term>
<term>Ferret</term>
<term>Hepatitis</term>
<term>Immunization</term>
<term>Immunoprophylaxis</term>
<term>Prevention</term>
<term>Recombinant virus</term>
<term>Respiratory tract</term>
<term>Severe</term>
<term>Severe acute respiratory syndrome</term>
<term>Vaccination</term>
<term>Vaccine</term>
<term>Vaccinia</term>
<term>Vaccinia virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus vaccine</term>
<term>Immunisation</term>
<term>Vaccin</term>
<term>Vaccination</term>
<term>Vaccine</term>
<term>Virus recombinant</term>
<term>Prévention</term>
<term>Immunoprophylaxie</term>
<term>Grave</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Hépatite</term>
<term>Malade état grave</term>
<term>Aigu</term>
<term>Voie respiratoire</term>
<term>Furet</term>
<term>Forme grave</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets.</title>
<author><name sortKey="Weingartl, Hana" sort="Weingartl, Hana" uniqKey="Weingartl H" first="Hana" last="Weingartl">Hana Weingartl</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 3R2.</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health, 1015 Arlington St., Winnipeg, Manitoba</wicri:regionArea>
<wicri:noRegion>Manitoba</wicri:noRegion>
</affiliation>
</author>
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<author><name sortKey="Czub, Stefanie" sort="Czub, Stefanie" uniqKey="Czub S" first="Stefanie" last="Czub">Stefanie Czub</name>
</author>
<author><name sortKey="Neufeld, James" sort="Neufeld, James" uniqKey="Neufeld J" first="James" last="Neufeld">James Neufeld</name>
</author>
<author><name sortKey="Marszal, Peter" sort="Marszal, Peter" uniqKey="Marszal P" first="Peter" last="Marszal">Peter Marszal</name>
</author>
<author><name sortKey="Gren, Jason" sort="Gren, Jason" uniqKey="Gren J" first="Jason" last="Gren">Jason Gren</name>
</author>
<author><name sortKey="Smith, Greg" sort="Smith, Greg" uniqKey="Smith G" first="Greg" last="Smith">Greg Smith</name>
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<author><name sortKey="Proulx, Roxanne" sort="Proulx, Roxanne" uniqKey="Proulx R" first="Roxanne" last="Proulx">Roxanne Proulx</name>
</author>
<author><name sortKey="Deschambault, Yvonne" sort="Deschambault, Yvonne" uniqKey="Deschambault Y" first="Yvonne" last="Deschambault">Yvonne Deschambault</name>
</author>
<author><name sortKey="Grudeski, Elsie" sort="Grudeski, Elsie" uniqKey="Grudeski E" first="Elsie" last="Grudeski">Elsie Grudeski</name>
</author>
<author><name sortKey="Andonov, Anton" sort="Andonov, Anton" uniqKey="Andonov A" first="Anton" last="Andonov">Anton Andonov</name>
</author>
<author><name sortKey="He, Runtao" sort="He, Runtao" uniqKey="He R" first="Runtao" last="He">Runtao He</name>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
</author>
<author><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name>
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</author>
<author><name sortKey="Manning, Lisa" sort="Manning, Lisa" uniqKey="Manning L" first="Lisa" last="Manning">Lisa Manning</name>
</author>
<author><name sortKey="Cao, Jingxin" sort="Cao, Jingxin" uniqKey="Cao J" first="Jingxin" last="Cao">Jingxin Cao</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2004">2004</date>
<idno type="RBID">pubmed:15507655</idno>
<idno type="pmid">15507655</idno>
<idno type="doi">10.1128/JVI.78.22.12672-12676.2004</idno>
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<idno type="wicri:doubleKey">0022-538X:2004:Weingartl H:immunization:with:modified</idno>
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</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets.</title>
<author><name sortKey="Weingartl, Hana" sort="Weingartl, Hana" uniqKey="Weingartl H" first="Hana" last="Weingartl">Hana Weingartl</name>
<affiliation wicri:level="1"><nlm:affiliation>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 3R2.</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health, 1015 Arlington St., Winnipeg, Manitoba</wicri:regionArea>
<wicri:noRegion>Manitoba</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Czub, Markus" sort="Czub, Markus" uniqKey="Czub M" first="Markus" last="Czub">Markus Czub</name>
</author>
<author><name sortKey="Czub, Stefanie" sort="Czub, Stefanie" uniqKey="Czub S" first="Stefanie" last="Czub">Stefanie Czub</name>
</author>
<author><name sortKey="Neufeld, James" sort="Neufeld, James" uniqKey="Neufeld J" first="James" last="Neufeld">James Neufeld</name>
</author>
<author><name sortKey="Marszal, Peter" sort="Marszal, Peter" uniqKey="Marszal P" first="Peter" last="Marszal">Peter Marszal</name>
</author>
<author><name sortKey="Gren, Jason" sort="Gren, Jason" uniqKey="Gren J" first="Jason" last="Gren">Jason Gren</name>
</author>
<author><name sortKey="Smith, Greg" sort="Smith, Greg" uniqKey="Smith G" first="Greg" last="Smith">Greg Smith</name>
</author>
<author><name sortKey="Jones, Shane" sort="Jones, Shane" uniqKey="Jones S" first="Shane" last="Jones">Shane Jones</name>
</author>
<author><name sortKey="Proulx, Roxanne" sort="Proulx, Roxanne" uniqKey="Proulx R" first="Roxanne" last="Proulx">Roxanne Proulx</name>
</author>
<author><name sortKey="Deschambault, Yvonne" sort="Deschambault, Yvonne" uniqKey="Deschambault Y" first="Yvonne" last="Deschambault">Yvonne Deschambault</name>
</author>
<author><name sortKey="Grudeski, Elsie" sort="Grudeski, Elsie" uniqKey="Grudeski E" first="Elsie" last="Grudeski">Elsie Grudeski</name>
</author>
<author><name sortKey="Andonov, Anton" sort="Andonov, Anton" uniqKey="Andonov A" first="Anton" last="Andonov">Anton Andonov</name>
</author>
<author><name sortKey="He, Runtao" sort="He, Runtao" uniqKey="He R" first="Runtao" last="He">Runtao He</name>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
</author>
<author><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name>
</author>
<author><name sortKey="Grolla, Allen" sort="Grolla, Allen" uniqKey="Grolla A" first="Allen" last="Grolla">Allen Grolla</name>
</author>
<author><name sortKey="Dick, Daryl" sort="Dick, Daryl" uniqKey="Dick D" first="Daryl" last="Dick">Daryl Dick</name>
</author>
<author><name sortKey="Berry, Jody" sort="Berry, Jody" uniqKey="Berry J" first="Jody" last="Berry">Jody Berry</name>
</author>
<author><name sortKey="Ganske, Shelley" sort="Ganske, Shelley" uniqKey="Ganske S" first="Shelley" last="Ganske">Shelley Ganske</name>
</author>
<author><name sortKey="Manning, Lisa" sort="Manning, Lisa" uniqKey="Manning L" first="Lisa" last="Manning">Lisa Manning</name>
</author>
<author><name sortKey="Cao, Jingxin" sort="Cao, Jingxin" uniqKey="Cao J" first="Jingxin" last="Cao">Jingxin Cao</name>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Viral (blood)</term>
<term>Ferrets</term>
<term>Hepatitis (etiology)</term>
<term>Liver (pathology)</term>
<term>Male</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>SARS Virus (immunology)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccination</term>
<term>Vaccines, Synthetic (adverse effects)</term>
<term>Vaccinia virus (immunology)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Envelope Proteins (immunology)</term>
<term>Viral Vaccines (adverse effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Foie (anatomopathologie)</term>
<term>Furets</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Glycoprotéines membranaires (immunologie)</term>
<term>Hépatite (étiologie)</term>
<term>Mâle</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>RT-PCR</term>
<term>Vaccination</term>
<term>Vaccins antiviraux (effets indésirables)</term>
<term>Vaccins synthétiques (effets indésirables)</term>
<term>Virus de la vaccine (immunologie)</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Vaccines, Synthetic</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antiviraux</term>
<term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hepatitis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
<term>Virus de la vaccine</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>SARS Virus</term>
<term>Vaccinia virus</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hépatite</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Ferrets</term>
<term>Male</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Furets</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Mâle</term>
<term>RT-PCR</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

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Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets

Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets

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