Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets
Identifieur interne : 000758 ( PascalFrancis/Corpus ); précédent : 000757; suivant : 000759Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets
Auteurs : Hana Weingartl ; Markus Czub ; Stefanie Czub ; James Neufeld ; Peter Marszal ; Jason Gren ; Greg Smith ; Shane Jones ; Roxanne Proulx ; Yvonne Deschambault ; Elsie Grudeski ; Anton Andonov ; RUNTAO HE ; YAN LI ; John Copps ; Allen Grolla ; Daryl Dick ; Jody Berry ; Shelley Ganske ; Lisa Manning ; JINGXIN CAOSource :
- Journal of virology [ 0022-538X ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.
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Format Inist (serveur)
| NO : | PASCAL 05-0001530 INIST |
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| ET : | Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets |
| AU : | WEINGARTL (Hana); CZUB (Markus); CZUB (Stefanie); NEUFELD (James); MARSZAL (Peter); GREN (Jason); SMITH (Greg); JONES (Shane); PROULX (Roxanne); DESCHAMBAULT (Yvonne); GRUDESKI (Elsie); ANDONOV (Anton); RUNTAO HE; YAN LI; COPPS (John); GROLLA (Allen); DICK (Daryl); BERRY (Jody); GANSKE (Shelley); MANNING (Lisa); JINGXIN CAO |
| AF : | National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health/Winnipeg, Manitoba, R3E 3R2/Canada (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 15 aut., 18 aut., 19 aut., 20 aut.); Department of Medical Microbiology, University of Manitoba/Winnipeg, Manitoba, R3T 2N2/Canada (1 aut., 2 aut., 3 aut., 12 aut., 13 aut., 14 aut., 18 aut., 21 aut.); National Microbiology Laboratory, 3 Canadian Science Centre for Human and Animal Health/Winnipeg, Manitoba, R3E 3R2/Canada (2 aut., 8 aut., 9 aut., 10 aut., 11 aut., 12 aut., 13 aut., 14 aut., 16 aut., 17 aut., 21 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Journal of virology; ISSN 0022-538X; Etats-Unis; Da. 2004; Vol. 78; No. 22; Pp. 12672-12676; Bibl. 19 ref. |
| LA : | Anglais |
| EA : | Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis. |
| CC : | 002A05C10; 002A05C07 |
| FD : | Virus vaccine; Immunisation; Vaccin; Vaccination; Vaccine; Virus recombinant; Prévention; Immunoprophylaxie; Grave; Syndrome respiratoire aigu sévère; Hépatite; Malade état grave; Aigu; Voie respiratoire; Furet; Forme grave |
| FG : | Orthopoxvirus; Chordopoxvirinae; Poxviridae; Virus; Virose; Infection; Appareil respiratoire pathologie; Poumon pathologie; Appareil respiratoire; Appareil digestif pathologie; Foie pathologie; Fissipedia; Carnivora; Mammalia; Vertebrata |
| ED : | Vaccinia virus; Immunization; Vaccine; Vaccination; Vaccinia; Recombinant virus; Prevention; Immunoprophylaxis; Severe; Severe acute respiratory syndrome; Hepatitis; Critically ill; Acute; Respiratory tract; Ferret |
| EG : | Orthopoxvirus; Chordopoxvirinae; Poxviridae; Virus; Viral disease; Infection; Respiratory disease; Lung disease; Respiratory system; Digestive diseases; Hepatic disease; Fissipedia; Carnivora; Mammalia; Vertebrata |
| SD : | Vaccinia virus; Inmunización; Vacuna; Vacunación; Vacuna(enfermedad); Virus recombinante; Prevención; Inmunoprofilaxia; Grave; Síndrome respiratorio agudo severo; Hepatitis; Enfermo estado grave; Agudo; Vía respiratoria; Hurón |
| LO : | INIST-13592.354000122578960600 |
| ID : | 05-0001530 |
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Pascal:05-0001530Le document en format XML
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Andonov</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Runtao He" sort="Runtao He" uniqKey="Runtao He" last="Runtao He">RUNTAO HE</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Yan Li" sort="Yan Li" uniqKey="Yan Li" last="Yan Li">YAN LI</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Grolla, Allen" sort="Grolla, Allen" uniqKey="Grolla A" first="Allen" last="Grolla">Allen Grolla</name><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dick, Daryl" sort="Dick, Daryl" uniqKey="Dick D" first="Daryl" last="Dick">Daryl Dick</name><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berry, Jody" sort="Berry, Jody" uniqKey="Berry J" first="Jody" last="Berry">Jody Berry</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ganske, Shelley" sort="Ganske, Shelley" uniqKey="Ganske S" first="Shelley" last="Ganske">Shelley Ganske</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Manning, Lisa" sort="Manning, Lisa" uniqKey="Manning L" first="Lisa" last="Manning">Lisa Manning</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Jingxin Cao" sort="Jingxin Cao" uniqKey="Jingxin Cao" last="Jingxin Cao">JINGXIN CAO</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0001530</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 05-0001530 INIST</idno><idno type="RBID">Pascal:05-0001530</idno><idno type="wicri:Area/PascalFrancis/Corpus">000758</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets</title><author><name sortKey="Weingartl, Hana" sort="Weingartl, Hana" uniqKey="Weingartl H" first="Hana" last="Weingartl">Hana Weingartl</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Czub, Markus" sort="Czub, Markus" uniqKey="Czub M" first="Markus" last="Czub">Markus Czub</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Czub, Stefanie" sort="Czub, Stefanie" uniqKey="Czub S" first="Stefanie" last="Czub">Stefanie Czub</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Neufeld, James" sort="Neufeld, James" uniqKey="Neufeld J" first="James" last="Neufeld">James Neufeld</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Marszal, Peter" sort="Marszal, Peter" uniqKey="Marszal P" first="Peter" last="Marszal">Peter Marszal</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gren, Jason" sort="Gren, Jason" uniqKey="Gren J" first="Jason" last="Gren">Jason Gren</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Smith, Greg" sort="Smith, Greg" uniqKey="Smith G" first="Greg" last="Smith">Greg Smith</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Jones, Shane" sort="Jones, Shane" uniqKey="Jones S" first="Shane" last="Jones">Shane Jones</name><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Proulx, Roxanne" sort="Proulx, Roxanne" uniqKey="Proulx R" first="Roxanne" last="Proulx">Roxanne Proulx</name><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Deschambault, Yvonne" sort="Deschambault, Yvonne" uniqKey="Deschambault Y" first="Yvonne" last="Deschambault">Yvonne Deschambault</name><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Grudeski, Elsie" sort="Grudeski, Elsie" uniqKey="Grudeski E" first="Elsie" last="Grudeski">Elsie Grudeski</name><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Andonov, Anton" sort="Andonov, Anton" uniqKey="Andonov A" first="Anton" last="Andonov">Anton Andonov</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Runtao He" sort="Runtao He" uniqKey="Runtao He" last="Runtao He">RUNTAO HE</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Yan Li" sort="Yan Li" uniqKey="Yan Li" last="Yan Li">YAN LI</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Grolla, Allen" sort="Grolla, Allen" uniqKey="Grolla A" first="Allen" last="Grolla">Allen Grolla</name><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dick, Daryl" sort="Dick, Daryl" uniqKey="Dick D" first="Daryl" last="Dick">Daryl Dick</name><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berry, Jody" sort="Berry, Jody" uniqKey="Berry J" first="Jody" last="Berry">Jody Berry</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ganske, Shelley" sort="Ganske, Shelley" uniqKey="Ganske S" first="Shelley" last="Ganske">Shelley Ganske</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Manning, Lisa" sort="Manning, Lisa" uniqKey="Manning L" first="Lisa" last="Manning">Lisa Manning</name><affiliation><inist:fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Jingxin Cao" sort="Jingxin Cao" uniqKey="Jingxin Cao" last="Jingxin Cao">JINGXIN CAO</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term><term>Critically ill</term><term>Ferret</term><term>Hepatitis</term><term>Immunization</term><term>Immunoprophylaxis</term><term>Prevention</term><term>Recombinant virus</term><term>Respiratory tract</term><term>Severe</term><term>Severe acute respiratory syndrome</term><term>Vaccination</term><term>Vaccine</term><term>Vaccinia</term><term>Vaccinia virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus vaccine</term><term>Immunisation</term><term>Vaccin</term><term>Vaccination</term><term>Vaccine</term><term>Virus recombinant</term><term>Prévention</term><term>Immunoprophylaxie</term><term>Grave</term><term>Syndrome respiratoire aigu sévère</term><term>Hépatite</term><term>Malade état grave</term><term>Aigu</term><term>Voie respiratoire</term><term>Furet</term><term>Forme grave</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-538X</s0></fA01><fA03 i2="1"><s0>J. virol.</s0></fA03><fA05><s2>78</s2></fA05><fA06><s2>22</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets</s1></fA08><fA11 i1="01" i2="1"><s1>WEINGARTL (Hana)</s1></fA11><fA11 i1="02" i2="1"><s1>CZUB (Markus)</s1></fA11><fA11 i1="03" i2="1"><s1>CZUB (Stefanie)</s1></fA11><fA11 i1="04" i2="1"><s1>NEUFELD (James)</s1></fA11><fA11 i1="05" i2="1"><s1>MARSZAL (Peter)</s1></fA11><fA11 i1="06" i2="1"><s1>GREN (Jason)</s1></fA11><fA11 i1="07" i2="1"><s1>SMITH (Greg)</s1></fA11><fA11 i1="08" i2="1"><s1>JONES (Shane)</s1></fA11><fA11 i1="09" i2="1"><s1>PROULX (Roxanne)</s1></fA11><fA11 i1="10" i2="1"><s1>DESCHAMBAULT (Yvonne)</s1></fA11><fA11 i1="11" i2="1"><s1>GRUDESKI (Elsie)</s1></fA11><fA11 i1="12" i2="1"><s1>ANDONOV (Anton)</s1></fA11><fA11 i1="13" i2="1"><s1>RUNTAO HE</s1></fA11><fA11 i1="14" i2="1"><s1>YAN LI</s1></fA11><fA11 i1="15" i2="1"><s1>COPPS (John)</s1></fA11><fA11 i1="16" i2="1"><s1>GROLLA (Allen)</s1></fA11><fA11 i1="17" i2="1"><s1>DICK (Daryl)</s1></fA11><fA11 i1="18" i2="1"><s1>BERRY (Jody)</s1></fA11><fA11 i1="19" i2="1"><s1>GANSKE (Shelley)</s1></fA11><fA11 i1="20" i2="1"><s1>MANNING (Lisa)</s1></fA11><fA11 i1="21" i2="1"><s1>JINGXIN CAO</s1></fA11><fA14 i1="01"><s1>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Medical Microbiology, University of Manitoba</s1><s2>Winnipeg, Manitoba, R3T 2N2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>21 aut.</sZ></fA14><fA14 i1="03"><s1>National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health</s1><s2>Winnipeg, Manitoba, R3E 3R2</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>21 aut.</sZ></fA14><fA20><s1>12672-12676</s1></fA20><fA21><s1>2004</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>13592</s2><s5>354000122578960600</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>19 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0001530</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of virology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05C10</s0></fC02><fC02 i1="02" i2="X"><s0>002A05C07</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Virus vaccine</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Vaccinia virus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Vaccinia virus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Immunisation</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Immunization</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Inmunización</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Vaccin</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Vaccine</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Vacuna</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Vaccination</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Vaccination</s0><s5>07</s5></fC03><fC03 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i1="12" i2="X" l="ENG"><s0>Fissipedia</s0><s2>NS</s2></fC07><fC07 i1="12" i2="X" l="SPA"><s0>Fissipedia</s0><s2>NS</s2></fC07><fC07 i1="13" i2="X" l="FRE"><s0>Carnivora</s0><s2>NS</s2></fC07><fC07 i1="13" i2="X" l="ENG"><s0>Carnivora</s0><s2>NS</s2></fC07><fC07 i1="13" i2="X" l="SPA"><s0>Carnivora</s0><s2>NS</s2></fC07><fC07 i1="14" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="14" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="14" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="15" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="15" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="15" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fN21><s1>004</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 05-0001530 INIST</NO><ET>Immunization with modified vaccinia virus ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets</ET><AU>WEINGARTL (Hana); CZUB (Markus); CZUB (Stefanie); NEUFELD (James); MARSZAL (Peter); GREN (Jason); SMITH (Greg); JONES (Shane); PROULX (Roxanne); DESCHAMBAULT (Yvonne); GRUDESKI (Elsie); ANDONOV (Anton); RUNTAO HE; YAN LI; COPPS (John); GROLLA (Allen); DICK (Daryl); BERRY (Jody); GANSKE (Shelley); MANNING (Lisa); JINGXIN CAO</AU><AF>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health/Winnipeg, Manitoba, R3E 3R2/Canada (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 15 aut., 18 aut., 19 aut., 20 aut.); Department of Medical Microbiology, University of Manitoba/Winnipeg, Manitoba, R3T 2N2/Canada (1 aut., 2 aut., 3 aut., 12 aut., 13 aut., 14 aut., 18 aut., 21 aut.); National Microbiology Laboratory, <sup>3</sup> Canadian Science Centre for Human and Animal Health/Winnipeg, Manitoba, R3E 3R2/Canada (2 aut., 8 aut., 9 aut., 10 aut., 11 aut., 12 aut., 13 aut., 14 aut., 16 aut., 17 aut., 21 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Journal of virology; ISSN 0022-538X; Etats-Unis; Da. 2004; Vol. 78; No. 22; Pp. 12672-12676; Bibl. 19 ref.</SO><LA>Anglais</LA><EA>Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.</EA><CC>002A05C10; 002A05C07</CC><FD>Virus vaccine; Immunisation; Vaccin; Vaccination; Vaccine; Virus recombinant; Prévention; Immunoprophylaxie; Grave; Syndrome respiratoire aigu sévère; Hépatite; Malade état grave; Aigu; Voie respiratoire; Furet; Forme grave</FD><FG>Orthopoxvirus; Chordopoxvirinae; Poxviridae; Virus; Virose; Infection; Appareil respiratoire pathologie; Poumon pathologie; Appareil respiratoire; Appareil digestif pathologie; Foie pathologie; Fissipedia; Carnivora; Mammalia; Vertebrata</FG><ED>Vaccinia virus; Immunization; Vaccine; Vaccination; Vaccinia; Recombinant virus; Prevention; Immunoprophylaxis; Severe; Severe acute respiratory syndrome; Hepatitis; Critically ill; Acute; Respiratory tract; Ferret</ED><EG>Orthopoxvirus; Chordopoxvirinae; Poxviridae; Virus; Viral disease; Infection; Respiratory disease; Lung disease; Respiratory system; Digestive diseases; Hepatic disease; Fissipedia; Carnivora; Mammalia; Vertebrata</EG><SD>Vaccinia virus; Inmunización; Vacuna; Vacunación; Vacuna(enfermedad); Virus recombinante; Prevención; Inmunoprofilaxia; Grave; Síndrome respiratorio agudo severo; Hepatitis; Enfermo estado grave; Agudo; Vía respiratoria; Hurón</SD><LO>INIST-13592.354000122578960600</LO><ID>05-0001530</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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