Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS
Identifieur interne : 003694 ( Main/Curation ); précédent : 003693; suivant : 003695Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS
Auteurs : Benoît Callendret [France] ; Valérie Lorin [France] ; Pierre Charneau [France] ; Philippe Marianneau [France] ; Hugues Contamin [France] ; Jean-Michel Betton [France] ; Sylvie Van Der Werf [France] ; Nicolas Escriou [France]Source :
- Virology [ 0042-6822 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Femelle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Glycoprotéines membranaires (métabolisme), Humains, Immunisation, Injections musculaires, Lignée cellulaire, Plasmides (génétique), Plasmides (métabolisme), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Protéines de l'enveloppe virale (métabolisme), Régulation de l'expression des gènes, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (sang), Tests de neutralisation, Transfection, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Vaccins à ADN (administration et posologie), Vaccins à ADN (immunologie), Vecteurs génétiques (génétique), Vecteurs génétiques (métabolisme), Virus Mason-Pfizer du singe (génétique), Virus de l'hépatite B de la marmotte (génétique), Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (métabolisme), Éléments activateurs (génétique) (physiologie).
- MESH :
- administration et posologie : Vaccins antiviraux, Vaccins à ADN.
- génétique : Glycoprotéines membranaires, Plasmides, Protéines de l'enveloppe virale, Vecteurs génétiques, Virus Mason-Pfizer du singe, Virus de l'hépatite B de la marmotte, Virus du SRAS.
- immunologie : Anticorps antiviraux, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Vaccins à ADN, Virus du SRAS.
- métabolisme : Glycoprotéines membranaires, Plasmides, Protéines de l'enveloppe virale, Vecteurs génétiques, Virus du SRAS.
- physiologie : Éléments activateurs (génétique).
- sang : Anticorps antiviraux, Syndrome respiratoire aigu sévère.
- Animaux, Femelle, Glycoprotéine de spicule des coronavirus, Humains, Immunisation, Injections musculaires, Lignée cellulaire, Régulation de l'expression des gènes, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère, Tests de neutralisation, Transfection.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Antibodies, Viral (immunology), Cell Line, Enhancer Elements, Genetic (physiology), Female, Gene Expression Regulation, Genetic Vectors (genetics), Genetic Vectors (metabolism), Hepatitis B Virus, Woodchuck (genetics), Humans, Immunization, Injections, Intramuscular, Mason-Pfizer monkey virus (genetics), Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Membrane Glycoproteins (metabolism), Mice, Mice, Inbred BALB C, Neutralization Tests, Plasmids (genetics), Plasmids (metabolism), SARS Virus (genetics), SARS Virus (immunology), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Spike Glycoprotein, Coronavirus, Transfection, Vaccines, DNA (administration & dosage), Vaccines, DNA (immunology), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Envelope Proteins (metabolism), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Vaccines, DNA, Viral Vaccines.
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , immunology : Antibodies, Viral, Membrane Glycoproteins, Vaccines, DNA, Viral Envelope Proteins, Viral Vaccines.
- blood : Severe Acute Respiratory Syndrome.
- genetics : Genetic Vectors, Hepatitis B Virus, Woodchuck, Mason-Pfizer monkey virus, Plasmids, SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- metabolism : Genetic Vectors, Membrane Glycoproteins, Plasmids, SARS Virus, Viral Envelope Proteins.
- physiology : Enhancer Elements, Genetic.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Female, Gene Expression Regulation, Humans, Immunization, Injections, Intramuscular, Mice, Mice, Inbred BALB C, Neutralization Tests, Spike Glycoprotein, Coronavirus, Transfection.
Abstract
The SARS-CoV spike glycoprotein (S) is the main target of the protective immune response in humans and animal models of SARS. Here, we demonstrated that efficient expression of S from the wild-type spike gene in cultured cells required the use of improved plasmid vectors containing donor and acceptor splice sites, as well as heterologous viral RNA export elements, such as the CTE of Mazon-Pfizer monkey virus or the PRE of Woodchuck hepatitis virus (WPRE). The presence of both splice sites and WPRE markedly improved the immunogenicity of S-based DNA vaccines against SARS. Upon immunization of mice with low doses (2 μg) of naked DNA, only intron and WPRE-containing vectors could induce neutralizing anti-S antibodies and provide protection against challenge with SARS-CoV. Our observations are likely to be useful for the construction of plasmid and viral vectors designed for optimal expression of intronless genes derived from cytoplasmic RNA viruses.
Url:
DOI: 10.1016/j.virol.2007.01.012
PubMed: 17331558
PubMed Central: 7103356
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PMC:7103356Le document en format XML
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<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Cell Line</term>
<term>Enhancer Elements, Genetic (physiology)</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Genetic Vectors (genetics)</term>
<term>Genetic Vectors (metabolism)</term>
<term>Hepatitis B Virus, Woodchuck (genetics)</term>
<term>Humans</term>
<term>Immunization</term>
<term>Injections, Intramuscular</term>
<term>Mason-Pfizer monkey virus (genetics)</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
<term>Plasmids (genetics)</term>
<term>Plasmids (metabolism)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (immunology)</term>
<term>SARS Virus (metabolism)</term>
<term>Severe Acute Respiratory Syndrome (blood)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (prevention & control)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Transfection</term>
<term>Vaccines, DNA (administration & dosage)</term>
<term>Vaccines, DNA (immunology)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Envelope Proteins (immunology)</term>
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<term>Viral Vaccines (administration & dosage)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
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<term>Anticorps antiviraux (sang)</term>
<term>Femelle</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Glycoprotéines membranaires (immunologie)</term>
<term>Glycoprotéines membranaires (métabolisme)</term>
<term>Humains</term>
<term>Immunisation</term>
<term>Injections musculaires</term>
<term>Lignée cellulaire</term>
<term>Plasmides (génétique)</term>
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<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Protéines de l'enveloppe virale (métabolisme)</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (sang)</term>
<term>Tests de neutralisation</term>
<term>Transfection</term>
<term>Vaccins antiviraux (administration et posologie)</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins à ADN (administration et posologie)</term>
<term>Vaccins à ADN (immunologie)</term>
<term>Vecteurs génétiques (génétique)</term>
<term>Vecteurs génétiques (métabolisme)</term>
<term>Virus Mason-Pfizer du singe (génétique)</term>
<term>Virus de l'hépatite B de la marmotte (génétique)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (métabolisme)</term>
<term>Éléments activateurs (génétique) (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines, DNA</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
<term>Membrane Glycoproteins</term>
<term>Vaccines, DNA</term>
<term>Viral Envelope Proteins</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term>
<term>Vaccins à ADN</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Vectors</term>
<term>Hepatitis B Virus, Woodchuck</term>
<term>Mason-Pfizer monkey virus</term>
<term>Plasmids</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Plasmides</term>
<term>Protéines de l'enveloppe virale</term>
<term>Vecteurs génétiques</term>
<term>Virus Mason-Pfizer du singe</term>
<term>Virus de l'hépatite B de la marmotte</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Vaccins antiviraux</term>
<term>Vaccins à ADN</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Genetic Vectors</term>
<term>Membrane Glycoproteins</term>
<term>Plasmids</term>
<term>SARS Virus</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Plasmides</term>
<term>Protéines de l'enveloppe virale</term>
<term>Vecteurs génétiques</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Éléments activateurs (génétique)</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Enhancer Elements, Genetic</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Immunization</term>
<term>Injections, Intramuscular</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Neutralization Tests</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Transfection</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Humains</term>
<term>Immunisation</term>
<term>Injections musculaires</term>
<term>Lignée cellulaire</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Tests de neutralisation</term>
<term>Transfection</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The SARS-CoV spike glycoprotein (S) is the main target of the protective immune response in humans and animal models of SARS. Here, we demonstrated that efficient expression of S from the wild-type spike gene in cultured cells required the use of improved plasmid vectors containing donor and acceptor splice sites, as well as heterologous viral RNA export elements, such as the CTE of Mazon-Pfizer monkey virus or the PRE of Woodchuck hepatitis virus (WPRE). The presence of both splice sites and WPRE markedly improved the immunogenicity of S-based DNA vaccines against SARS. Upon immunization of mice with low doses (2 μg) of naked DNA, only intron and WPRE-containing vectors could induce neutralizing anti-S antibodies and provide protection against challenge with SARS-CoV. Our observations are likely to be useful for the construction of plasmid and viral vectors designed for optimal expression of intronless genes derived from cytoplasmic RNA viruses.</p>
</div>
</front>
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<author><name sortKey="Suchma, K" uniqKey="Suchma K">K. Suchma</name>
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<author><name sortKey="Weiss, S R" uniqKey="Weiss S">S.R. Weiss</name>
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<author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name>
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<author><name sortKey="Schumer, G" uniqKey="Schumer G">G. Schumer</name>
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<author><name sortKey="Gao, G" uniqKey="Gao G">G. Gao</name>
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<author><name sortKey="Boyer, J L" uniqKey="Boyer J">J.L. Boyer</name>
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<author><name sortKey="Crystal, R G" uniqKey="Crystal R">R.G. Crystal</name>
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<author><name sortKey="Donello, J E" uniqKey="Donello J">J.E. Donello</name>
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<author><name sortKey="Trono, D" uniqKey="Trono D">D. Trono</name>
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<author><name sortKey="Hope, T J" uniqKey="Hope T">T.J. Hope</name>
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