Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS
Identifieur interne : 001557 ( Pmc/Curation ); précédent : 001556; suivant : 001558Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS
Auteurs : Benoît Callendret [France] ; Valérie Lorin [France] ; Pierre Charneau [France] ; Philippe Marianneau [France] ; Hugues Contamin [France] ; Jean-Michel Betton [France] ; Sylvie Van Der Werf [France] ; Nicolas Escriou [France]Source :
- Virology [ 0042-6822 ] ; 2007.
Abstract
The SARS-CoV spike glycoprotein (S) is the main target of the protective immune response in humans and animal models of SARS. Here, we demonstrated that efficient expression of S from the wild-type spike gene in cultured cells required the use of improved plasmid vectors containing donor and acceptor splice sites, as well as heterologous viral RNA export elements, such as the CTE of Mazon-Pfizer monkey virus or the PRE of Woodchuck hepatitis virus (WPRE). The presence of both splice sites and WPRE markedly improved the immunogenicity of S-based DNA vaccines against SARS. Upon immunization of mice with low doses (2 μg) of naked DNA, only intron and WPRE-containing vectors could induce neutralizing anti-S antibodies and provide protection against challenge with SARS-CoV. Our observations are likely to be useful for the construction of plasmid and viral vectors designed for optimal expression of intronless genes derived from cytoplasmic RNA viruses.
Url:
DOI: 10.1016/j.virol.2007.01.012
PubMed: 17331558
PubMed Central: 7103356
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<front><div type="abstract" xml:lang="en"><p>The SARS-CoV spike glycoprotein (S) is the main target of the protective immune response in humans and animal models of SARS. Here, we demonstrated that efficient expression of S from the wild-type spike gene in cultured cells required the use of improved plasmid vectors containing donor and acceptor splice sites, as well as heterologous viral RNA export elements, such as the CTE of Mazon-Pfizer monkey virus or the PRE of Woodchuck hepatitis virus (WPRE). The presence of both splice sites and WPRE markedly improved the immunogenicity of S-based DNA vaccines against SARS. Upon immunization of mice with low doses (2 μg) of naked DNA, only intron and WPRE-containing vectors could induce neutralizing anti-S antibodies and provide protection against challenge with SARS-CoV. Our observations are likely to be useful for the construction of plasmid and viral vectors designed for optimal expression of intronless genes derived from cytoplasmic RNA viruses.</p>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Virology</journal-id>
<journal-id journal-id-type="iso-abbrev">Virology</journal-id>
<journal-title-group><journal-title>Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0042-6822</issn>
<issn pub-type="epub">1096-0341</issn>
<publisher><publisher-name>Elsevier Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17331558</article-id>
<article-id pub-id-type="pmc">7103356</article-id>
<article-id pub-id-type="publisher-id">S0042-6822(07)00028-1</article-id>
<article-id pub-id-type="doi">10.1016/j.virol.2007.01.012</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Callendret</surname>
<given-names>Benoît</given-names>
</name>
<email>benoitcl@pasteur.fr</email>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lorin</surname>
<given-names>Valérie</given-names>
</name>
<email>vlorin@pasteur.fr</email>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Charneau</surname>
<given-names>Pierre</given-names>
</name>
<email>charneau@pasteur.fr</email>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marianneau</surname>
<given-names>Philippe</given-names>
</name>
<email>marianneau@cervi-lyon.inserm.fr</email>
<xref rid="aff3" ref-type="aff">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Contamin</surname>
<given-names>Hugues</given-names>
</name>
<email>Hugues.Contamin@mdsinc.com</email>
<xref rid="aff3" ref-type="aff">d</xref>
<xref rid="fn1" ref-type="fn">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Betton</surname>
<given-names>Jean-Michel</given-names>
</name>
<email>jmbetton@pasteur.fr</email>
<xref rid="aff4" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van der Werf</surname>
<given-names>Sylvie</given-names>
</name>
<email>svdwerf@pasteur.fr</email>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Escriou</surname>
<given-names>Nicolas</given-names>
</name>
<email>escriou@pasteur.fr</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="cor1" ref-type="corresp">⁎</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
Unité de Génétique Moléculaire des Virus Respiratoires, URA CNRS 1966, EA 302 Université Paris 7, France</aff>
<aff id="aff2"><label>b</label>
Groupe à 5 ans de Virologie Moléculaire et de Vectorologie, France</aff>
<aff id="aff4"><label>c</label>
Unité de Biochimie Structurale, URA CNRS 2185, Institut Pasteur, 25 rue du Dr. Roux, 75724 PARIS Cedex 15, France</aff>
<aff id="aff3"><label>d</label>
Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, IFR 128 BioSciences Lyon-Gerland, 21 avenue Tony Garnier, 69365 Lyon Cedex 07, France</aff>
<author-notes><corresp id="cor1"><label>⁎</label>
Corresponding author. Unité de Génétique Moléculaire des Virus Respiratoires, URA CNRS 1966, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France. Fax: +33 140613241. <email>escriou@pasteur.fr</email>
</corresp>
<fn id="fn1"><label>1</label>
<p>Present address: MDS Pharma Service, les Oncins, 69210 Saint Germain sur l'Arbresle, France.</p>
</fn>
</author-notes>
<pub-date pub-type="pmc-release"><day>28</day>
<month>2</month>
<year>2007</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>5</day>
<month>7</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>2</month>
<year>2007</year>
</pub-date>
<volume>363</volume>
<issue>2</issue>
<fpage>288</fpage>
<lpage>302</lpage>
<history><date date-type="received"><day>10</day>
<month>10</month>
<year>2006</year>
</date>
<date date-type="rev-recd"><day>19</day>
<month>12</month>
<year>2006</year>
</date>
<date date-type="accepted"><day>15</day>
<month>1</month>
<year>2007</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2007 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2007</copyright-year>
<copyright-holder>Elsevier Inc.</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract><p>The SARS-CoV spike glycoprotein (S) is the main target of the protective immune response in humans and animal models of SARS. Here, we demonstrated that efficient expression of S from the wild-type spike gene in cultured cells required the use of improved plasmid vectors containing donor and acceptor splice sites, as well as heterologous viral RNA export elements, such as the CTE of Mazon-Pfizer monkey virus or the PRE of Woodchuck hepatitis virus (WPRE). The presence of both splice sites and WPRE markedly improved the immunogenicity of S-based DNA vaccines against SARS. Upon immunization of mice with low doses (2 μg) of naked DNA, only intron and WPRE-containing vectors could induce neutralizing anti-S antibodies and provide protection against challenge with SARS-CoV. Our observations are likely to be useful for the construction of plasmid and viral vectors designed for optimal expression of intronless genes derived from cytoplasmic RNA viruses.</p>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>Coronavirus</kwd>
<kwd>Severe acute respiratory syndrome</kwd>
<kwd>Spike glycoprotein</kwd>
<kwd>Viral RNA export element</kwd>
<kwd>CTE</kwd>
<kwd>WPRE</kwd>
<kwd>DNA vaccine</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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