SrasV1, Main, Curation, bibRecord, 003496

Immunomodulatory and anti-SARS activities of Houttuynia cordata

Identifieur interne : 003496 ( Main/Curation ); précédent : 003495; suivant : 003497

Immunomodulatory and anti-SARS activities of Houttuynia cordata

Auteurs : Kit-Man Lau [Hong Kong] ; Kin-Ming Lee [Hong Kong] ; Chi-Man Koon [Hong Kong] ; Crystal Sao-Fong Cheung [Hong Kong] ; Ching-Po Lau [Hong Kong] ; Hei-Ming Ho [Hong Kong] ; Mavis Yuk-Ha Lee [Hong Kong] ; Shannon Wing-Ngor Au [Hong Kong] ; Christopher Hon-Ki Cheng [Hong Kong] ; Clara Bik-San Lau [Hong Kong] ; Stephen Kwok-Wing Tsui [Hong Kong] ; David Chi-Cheong Wan [Hong Kong] ; Mary Miu-Yee Waye [Hong Kong] ; Kam-Bo Wong [Hong Kong] ; Chun-Kwok Wong [Hong Kong] ; Christopher Wai-Kei Lam [Hong Kong] ; Ping-Chung Leung [Hong Kong] ; Kwok-Pui Fung [Hong Kong]

Source :

Journal of ethnopharmacology [ 0378-8741 ] ; 2008.

RBID : Pascal:08-0330765

Descripteurs français

KwdFr :
- Administration par voie orale, Animaux, Antiviraux (administration et posologie), Antiviraux (isolement et purification), Antiviraux (toxicité), Chine, Cytométrie en flux, Femelle, Lymphocytes T CD4+ (), Lymphocytes T CD4+ (métabolisme), Lymphocytes T CD8+ (), Lymphocytes T CD8+ (métabolisme), Médicaments issus de plantes chinoises (administration et posologie), Médicaments issus de plantes chinoises (toxicité), Prolifération cellulaire (), Rate (cytologie), Relation dose-effet des médicaments, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (traitement médicamenteux), Tests de toxicité aigüe, Virus du SRAS ().
MESH :
- administration et posologie : Antiviraux, Médicaments issus de plantes chinoises.
- cytologie : Rate.
- isolement et purification : Antiviraux.
- métabolisme : Lymphocytes T CD4+, Lymphocytes T CD8+.
- toxicité : Antiviraux, Médicaments issus de plantes chinoises.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
Pascal (Inist)
- Administration par voie orale, Animaux, Chine, Cytométrie en flux, Femelle, Immunomodulateur, Lymphocytes T CD4+, Lymphocytes T CD8+, Prolifération cellulaire, Relation dose-effet des médicaments, Souris, Souris de lignée BALB C, Tests de toxicité aigüe, Virus du SRAS, Virus syndrome respiratoire aigu sévère, DNA-directed RNA polymerase, Pharmacognosie, Plante médicinale, Origine végétale.
Wicri :
- geographic : République populaire de Chine.
- topic : Plante médicinale.

English descriptors

KwdEn :
- Administration, Oral, Animals, Antiviral Agents (administration & dosage), Antiviral Agents (isolation & purification), Antiviral Agents (toxicity), CD4-Positive T-Lymphocytes (drug effects), CD4-Positive T-Lymphocytes (metabolism), CD8-Positive T-Lymphocytes (drug effects), CD8-Positive T-Lymphocytes (metabolism), Cell Proliferation (drug effects), China, DNA-directed RNA polymerase, Dose-Response Relationship, Drug, Drugs, Chinese Herbal (administration & dosage), Drugs, Chinese Herbal (toxicity), Female, Flow Cytometry, Immunomodulator, Medicinal plant, Mice, Mice, Inbred BALB C, Pharmacognosy, Plant origin, SARS Virus (drug effects), Severe Acute Respiratory Syndrome (drug therapy), Severe acute respiratory syndrome virus, Spleen (cytology), Toxicity Tests, Acute.
MESH :
- chemical , administration & dosage : Antiviral Agents, Drugs, Chinese Herbal.
- chemical , isolation & purification : Antiviral Agents.
- chemical , toxicity : Antiviral Agents, Drugs, Chinese Herbal.
- geographic : China.
- cytology : Spleen.
- drug effects : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Proliferation, SARS Virus.
- drug therapy : Severe Acute Respiratory Syndrome.
- metabolism : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes.
- Administration, Oral, Animals, Dose-Response Relationship, Drug, Female, Flow Cytometry, Mice, Mice, Inbred BALB C, Toxicity Tests, Acute.

Abstract

Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4⁺ and CD8⁺ T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL^Pro) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.

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Le document en format XML

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<author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name>
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<author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
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<author><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name>
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<author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name>
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<author><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name>
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<author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
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<author><name sortKey="Lee, Kin Ming" sort="Lee, Kin Ming" uniqKey="Lee K" first="Kin-Ming" last="Lee">Kin-Ming Lee</name>
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<sZ>18 aut.</sZ>
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<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Koon, Chi Man" sort="Koon, Chi Man" uniqKey="Koon C" first="Chi-Man" last="Koon">Chi-Man Koon</name>
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<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Cheung, Crystal Sao Fong" sort="Cheung, Crystal Sao Fong" uniqKey="Cheung C" first="Crystal Sao-Fong" last="Cheung">Crystal Sao-Fong Cheung</name>
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</affiliation>
</author>
<author><name sortKey="Lau, Ching Po" sort="Lau, Ching Po" uniqKey="Lau C" first="Ching-Po" last="Lau">Ching-Po Lau</name>
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<sZ>3 aut.</sZ>
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<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
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</author>
<author><name sortKey="Ho, Hei Ming" sort="Ho, Hei Ming" uniqKey="Ho H" first="Hei-Ming" last="Ho">Hei-Ming Ho</name>
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<s2>Shatin</s2>
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<sZ>6 aut.</sZ>
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<sZ>18 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Lee, Mavis Yuk Ha" sort="Lee, Mavis Yuk Ha" uniqKey="Lee M" first="Mavis Yuk-Ha" last="Lee">Mavis Yuk-Ha Lee</name>
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<s2>Shatin</s2>
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<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
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</author>
<author><name sortKey="Au, Shannon Wing Ngor" sort="Au, Shannon Wing Ngor" uniqKey="Au S" first="Shannon Wing-Ngor" last="Au">Shannon Wing-Ngor Au</name>
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</affiliation>
</author>
<author><name sortKey="Cheng, Christopher Hon Ki" sort="Cheng, Christopher Hon Ki" uniqKey="Cheng C" first="Christopher Hon-Ki" last="Cheng">Christopher Hon-Ki Cheng</name>
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<s3>HKG</s3>
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<sZ>6 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Lau, Clara Bik San" sort="Lau, Clara Bik San" uniqKey="Lau C" first="Clara Bik-San" last="Lau">Clara Bik-San Lau</name>
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<s2>Shatin</s2>
<s3>HKG</s3>
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</inist:fA14>
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<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Tsui, Stephen Kwok Wing" sort="Tsui, Stephen Kwok Wing" uniqKey="Tsui S" first="Stephen Kwok-Wing" last="Tsui">Stephen Kwok-Wing Tsui</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
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<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
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<author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
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<author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
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<s2>Shatin</s2>
<s3>HKG</s3>
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</affiliation>
</author>
<author><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
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</author>
<author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
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<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
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<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
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<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
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</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of ethnopharmacology</title>
<title level="j" type="abbreviated">J. ethnopharmacol.</title>
<idno type="ISSN">0378-8741</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
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</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of ethnopharmacology</title>
<title level="j" type="abbreviated">J. ethnopharmacol.</title>
<idno type="ISSN">0378-8741</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term>
<term>Animals</term>
<term>Antiviral Agents (administration & dosage)</term>
<term>Antiviral Agents (isolation & purification)</term>
<term>Antiviral Agents (toxicity)</term>
<term>CD4-Positive T-Lymphocytes (drug effects)</term>
<term>CD4-Positive T-Lymphocytes (metabolism)</term>
<term>CD8-Positive T-Lymphocytes (drug effects)</term>
<term>CD8-Positive T-Lymphocytes (metabolism)</term>
<term>Cell Proliferation (drug effects)</term>
<term>China</term>
<term>DNA-directed RNA polymerase</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drugs, Chinese Herbal (administration & dosage)</term>
<term>Drugs, Chinese Herbal (toxicity)</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Immunomodulator</term>
<term>Medicinal plant</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Pharmacognosy</term>
<term>Plant origin</term>
<term>SARS Virus (drug effects)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Spleen (cytology)</term>
<term>Toxicity Tests, Acute</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term>
<term>Animaux</term>
<term>Antiviraux (administration et posologie)</term>
<term>Antiviraux (isolement et purification)</term>
<term>Antiviraux (toxicité)</term>
<term>Chine</term>
<term>Cytométrie en flux</term>
<term>Femelle</term>
<term>Lymphocytes T CD4+ ()</term>
<term>Lymphocytes T CD4+ (métabolisme)</term>
<term>Lymphocytes T CD8+ ()</term>
<term>Lymphocytes T CD8+ (métabolisme)</term>
<term>Médicaments issus de plantes chinoises (administration et posologie)</term>
<term>Médicaments issus de plantes chinoises (toxicité)</term>
<term>Prolifération cellulaire ()</term>
<term>Rate (cytologie)</term>
<term>Relation dose-effet des médicaments</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Tests de toxicité aigüe</term>
<term>Virus du SRAS ()</term>
</keywords>
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<term>Drugs, Chinese Herbal</term>
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</keywords>
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<term>Drugs, Chinese Herbal</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
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<term>Médicaments issus de plantes chinoises</term>
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<term>CD8-Positive T-Lymphocytes</term>
<term>Cell Proliferation</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term>
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<term>Lymphocytes T CD8+</term>
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<term>Médicaments issus de plantes chinoises</term>
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</keywords>
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<term>Animals</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Toxicity Tests, Acute</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Administration par voie orale</term>
<term>Animaux</term>
<term>Chine</term>
<term>Cytométrie en flux</term>
<term>Femelle</term>
<term>Immunomodulateur</term>
<term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
<term>Prolifération cellulaire</term>
<term>Relation dose-effet des médicaments</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Tests de toxicité aigüe</term>
<term>Virus du SRAS</term>
<term>Virus syndrome respiratoire aigu sévère</term>
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<term>Origine végétale</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
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<front><div type="abstract" xml:lang="en">Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4<sup>+</sup>
 and CD8<sup>+</sup>
 T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL<sup>Pro</sup>
) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.</div>
</front>
</TEI>
<double idat="0378-8741:2008:Lau K:immunomodulatory:and:anti"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Immunomodulatory and anti-SARS activities of Houttuynia cordata</title>
<author><name sortKey="Lau, Kit Man" sort="Lau, Kit Man" uniqKey="Lau K" first="Kit-Man" last="Lau">Kit-Man Lau</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
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<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Lee, Kin Ming" sort="Lee, Kin Ming" uniqKey="Lee K" first="Kin-Ming" last="Lee">Kin-Ming Lee</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
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<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Koon, Chi Man" sort="Koon, Chi Man" uniqKey="Koon C" first="Chi-Man" last="Koon">Chi-Man Koon</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Cheung, Crystal Sao Fong" sort="Cheung, Crystal Sao Fong" uniqKey="Cheung C" first="Crystal Sao-Fong" last="Cheung">Crystal Sao-Fong Cheung</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lau, Ching Po" sort="Lau, Ching Po" uniqKey="Lau C" first="Ching-Po" last="Lau">Ching-Po Lau</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Ho, Hei Ming" sort="Ho, Hei Ming" uniqKey="Ho H" first="Hei-Ming" last="Ho">Hei-Ming Ho</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Mavis Yuk Ha" sort="Lee, Mavis Yuk Ha" uniqKey="Lee M" first="Mavis Yuk-Ha" last="Lee">Mavis Yuk-Ha Lee</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Au, Shannon Wing Ngor" sort="Au, Shannon Wing Ngor" uniqKey="Au S" first="Shannon Wing-Ngor" last="Au">Shannon Wing-Ngor Au</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cheng, Christopher Hon Ki" sort="Cheng, Christopher Hon Ki" uniqKey="Cheng C" first="Christopher Hon-Ki" last="Cheng">Christopher Hon-Ki Cheng</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lau, Clara Bik San" sort="Lau, Clara Bik San" uniqKey="Lau C" first="Clara Bik-San" last="Lau">Clara Bik-San Lau</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>School of Pharmacy, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Tsui, Stephen Kwok Wing" sort="Tsui, Stephen Kwok Wing" uniqKey="Tsui S" first="Stephen Kwok-Wing" last="Tsui">Stephen Kwok-Wing Tsui</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0330765</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0330765 INIST</idno>
<idno type="RBID">Pascal:08-0330765</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000274</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000714</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000276</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000276</idno>
<idno type="wicri:doubleKey">0378-8741:2008:Lau K:immunomodulatory:and:anti</idno>
<idno type="wicri:Area/Main/Merge">003602</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immunomodulatory and anti-SARS activities of Houttuynia cordata</title>
<author><name sortKey="Lau, Kit Man" sort="Lau, Kit Man" uniqKey="Lau K" first="Kit-Man" last="Lau">Kit-Man Lau</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Lee, Kin Ming" sort="Lee, Kin Ming" uniqKey="Lee K" first="Kin-Ming" last="Lee">Kin-Ming Lee</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Koon, Chi Man" sort="Koon, Chi Man" uniqKey="Koon C" first="Chi-Man" last="Koon">Chi-Man Koon</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Cheung, Crystal Sao Fong" sort="Cheung, Crystal Sao Fong" uniqKey="Cheung C" first="Crystal Sao-Fong" last="Cheung">Crystal Sao-Fong Cheung</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lau, Ching Po" sort="Lau, Ching Po" uniqKey="Lau C" first="Ching-Po" last="Lau">Ching-Po Lau</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Ho, Hei Ming" sort="Ho, Hei Ming" uniqKey="Ho H" first="Hei-Ming" last="Ho">Hei-Ming Ho</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Mavis Yuk Ha" sort="Lee, Mavis Yuk Ha" uniqKey="Lee M" first="Mavis Yuk-Ha" last="Lee">Mavis Yuk-Ha Lee</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Au, Shannon Wing Ngor" sort="Au, Shannon Wing Ngor" uniqKey="Au S" first="Shannon Wing-Ngor" last="Au">Shannon Wing-Ngor Au</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cheng, Christopher Hon Ki" sort="Cheng, Christopher Hon Ki" uniqKey="Cheng C" first="Christopher Hon-Ki" last="Cheng">Christopher Hon-Ki Cheng</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lau, Clara Bik San" sort="Lau, Clara Bik San" uniqKey="Lau C" first="Clara Bik-San" last="Lau">Clara Bik-San Lau</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>School of Pharmacy, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Tsui, Stephen Kwok Wing" sort="Tsui, Stephen Kwok Wing" uniqKey="Tsui S" first="Stephen Kwok-Wing" last="Tsui">Stephen Kwok-Wing Tsui</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1>
<s2>Shatin</s2>
<s3>HKG</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Department of Biochemistry. The Chinese University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of ethnopharmacology</title>
<title level="j" type="abbreviated">J. ethnopharmacol.</title>
<idno type="ISSN">0378-8741</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of ethnopharmacology</title>
<title level="j" type="abbreviated">J. ethnopharmacol.</title>
<idno type="ISSN">0378-8741</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA-directed RNA polymerase</term>
<term>Immunomodulator</term>
<term>Medicinal plant</term>
<term>Pharmacognosy</term>
<term>Plant origin</term>
<term>Severe acute respiratory syndrome virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Immunomodulateur</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>DNA-directed RNA polymerase</term>
<term>Pharmacognosie</term>
<term>Plante médicinale</term>
<term>Origine végétale</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plante médicinale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4<sup>+</sup>
 and CD8<sup>+</sup>
 T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL<sup>Pro</sup>
) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunomodulatory and anti-SARS activities of Houttuynia cordata.</title>
<author><name sortKey="Lau, Kit Man" sort="Lau, Kit Man" uniqKey="Lau K" first="Kit-Man" last="Lau">Kit-Man Lau</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lee, Kin Ming" sort="Lee, Kin Ming" uniqKey="Lee K" first="Kin-Ming" last="Lee">Kin-Ming Lee</name>
</author>
<author><name sortKey="Koon, Chi Man" sort="Koon, Chi Man" uniqKey="Koon C" first="Chi-Man" last="Koon">Chi-Man Koon</name>
</author>
<author><name sortKey="Cheung, Crystal Sao Fong" sort="Cheung, Crystal Sao Fong" uniqKey="Cheung C" first="Crystal Sao-Fong" last="Cheung">Crystal Sao-Fong Cheung</name>
</author>
<author><name sortKey="Lau, Ching Po" sort="Lau, Ching Po" uniqKey="Lau C" first="Ching-Po" last="Lau">Ching-Po Lau</name>
</author>
<author><name sortKey="Ho, Hei Ming" sort="Ho, Hei Ming" uniqKey="Ho H" first="Hei-Ming" last="Ho">Hei-Ming Ho</name>
</author>
<author><name sortKey="Lee, Mavis Yuk Ha" sort="Lee, Mavis Yuk Ha" uniqKey="Lee M" first="Mavis Yuk-Ha" last="Lee">Mavis Yuk-Ha Lee</name>
</author>
<author><name sortKey="Au, Shannon Wing Ngor" sort="Au, Shannon Wing Ngor" uniqKey="Au S" first="Shannon Wing-Ngor" last="Au">Shannon Wing-Ngor Au</name>
</author>
<author><name sortKey="Cheng, Christopher Hon Ki" sort="Cheng, Christopher Hon Ki" uniqKey="Cheng C" first="Christopher Hon-Ki" last="Cheng">Christopher Hon-Ki Cheng</name>
</author>
<author><name sortKey="Lau, Clara Bik San" sort="Lau, Clara Bik San" uniqKey="Lau C" first="Clara Bik-San" last="Lau">Clara Bik-San Lau</name>
</author>
<author><name sortKey="Tsui, Stephen Kwok Wing" sort="Tsui, Stephen Kwok Wing" uniqKey="Tsui S" first="Stephen Kwok-Wing" last="Tsui">Stephen Kwok-Wing Tsui</name>
</author>
<author><name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name>
</author>
<author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name>
</author>
<author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
</author>
<author><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name>
</author>
<author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name>
</author>
<author><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name>
</author>
<author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="RBID">pubmed:18479853</idno>
<idno type="pmid">18479853</idno>
<idno type="doi">10.1016/j.jep.2008.03.018</idno>
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<idno type="wicri:Area/Main/Merge">003177</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Immunomodulatory and anti-SARS activities of Houttuynia cordata.</title>
<author><name sortKey="Lau, Kit Man" sort="Lau, Kit Man" uniqKey="Lau K" first="Kit-Man" last="Lau">Kit-Man Lau</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lee, Kin Ming" sort="Lee, Kin Ming" uniqKey="Lee K" first="Kin-Ming" last="Lee">Kin-Ming Lee</name>
</author>
<author><name sortKey="Koon, Chi Man" sort="Koon, Chi Man" uniqKey="Koon C" first="Chi-Man" last="Koon">Chi-Man Koon</name>
</author>
<author><name sortKey="Cheung, Crystal Sao Fong" sort="Cheung, Crystal Sao Fong" uniqKey="Cheung C" first="Crystal Sao-Fong" last="Cheung">Crystal Sao-Fong Cheung</name>
</author>
<author><name sortKey="Lau, Ching Po" sort="Lau, Ching Po" uniqKey="Lau C" first="Ching-Po" last="Lau">Ching-Po Lau</name>
</author>
<author><name sortKey="Ho, Hei Ming" sort="Ho, Hei Ming" uniqKey="Ho H" first="Hei-Ming" last="Ho">Hei-Ming Ho</name>
</author>
<author><name sortKey="Lee, Mavis Yuk Ha" sort="Lee, Mavis Yuk Ha" uniqKey="Lee M" first="Mavis Yuk-Ha" last="Lee">Mavis Yuk-Ha Lee</name>
</author>
<author><name sortKey="Au, Shannon Wing Ngor" sort="Au, Shannon Wing Ngor" uniqKey="Au S" first="Shannon Wing-Ngor" last="Au">Shannon Wing-Ngor Au</name>
</author>
<author><name sortKey="Cheng, Christopher Hon Ki" sort="Cheng, Christopher Hon Ki" uniqKey="Cheng C" first="Christopher Hon-Ki" last="Cheng">Christopher Hon-Ki Cheng</name>
</author>
<author><name sortKey="Lau, Clara Bik San" sort="Lau, Clara Bik San" uniqKey="Lau C" first="Clara Bik-San" last="Lau">Clara Bik-San Lau</name>
</author>
<author><name sortKey="Tsui, Stephen Kwok Wing" sort="Tsui, Stephen Kwok Wing" uniqKey="Tsui S" first="Stephen Kwok-Wing" last="Tsui">Stephen Kwok-Wing Tsui</name>
</author>
<author><name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name>
</author>
<author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name>
</author>
<author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name>
</author>
<author><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name>
</author>
<author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name>
</author>
<author><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name>
</author>
<author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name>
</author>
</analytic>
<series><title level="j">Journal of ethnopharmacology</title>
<idno type="ISSN">0378-8741</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term>
<term>Animals</term>
<term>Antiviral Agents (administration & dosage)</term>
<term>Antiviral Agents (isolation & purification)</term>
<term>Antiviral Agents (toxicity)</term>
<term>CD4-Positive T-Lymphocytes (drug effects)</term>
<term>CD4-Positive T-Lymphocytes (metabolism)</term>
<term>CD8-Positive T-Lymphocytes (drug effects)</term>
<term>CD8-Positive T-Lymphocytes (metabolism)</term>
<term>Cell Proliferation (drug effects)</term>
<term>China</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drugs, Chinese Herbal (administration & dosage)</term>
<term>Drugs, Chinese Herbal (toxicity)</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>SARS Virus (drug effects)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Spleen (cytology)</term>
<term>Toxicity Tests, Acute</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term>
<term>Animaux</term>
<term>Antiviraux (administration et posologie)</term>
<term>Antiviraux (isolement et purification)</term>
<term>Antiviraux (toxicité)</term>
<term>Chine</term>
<term>Cytométrie en flux</term>
<term>Femelle</term>
<term>Lymphocytes T CD4+ ()</term>
<term>Lymphocytes T CD4+ (métabolisme)</term>
<term>Lymphocytes T CD8+ ()</term>
<term>Lymphocytes T CD8+ (métabolisme)</term>
<term>Médicaments issus de plantes chinoises (administration et posologie)</term>
<term>Médicaments issus de plantes chinoises (toxicité)</term>
<term>Prolifération cellulaire ()</term>
<term>Rate (cytologie)</term>
<term>Relation dose-effet des médicaments</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Tests de toxicité aigüe</term>
<term>Virus du SRAS ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term>
<term>Drugs, Chinese Herbal</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antiviral Agents</term>
<term>Drugs, Chinese Herbal</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term>
<term>Médicaments issus de plantes chinoises</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rate</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Spleen</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>Cell Proliferation</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Antiviraux</term>
<term>Médicaments issus de plantes chinoises</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term>
<term>Animals</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Toxicity Tests, Acute</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term>
<term>Animaux</term>
<term>Chine</term>
<term>Cytométrie en flux</term>
<term>Femelle</term>
<term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
<term>Prolifération cellulaire</term>
<term>Relation dose-effet des médicaments</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Tests de toxicité aigüe</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae)(HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

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Immunomodulatory and anti-SARS activities of Houttuynia cordata

Immunomodulatory and anti-SARS activities of Houttuynia cordata

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