Immunomodulatory and anti-SARS activities of Houttuynia cordata
Identifieur interne : 000274 ( PascalFrancis/Corpus ); précédent : 000273; suivant : 000275Immunomodulatory and anti-SARS activities of Houttuynia cordata
Auteurs : Kit-Man Lau ; Kin-Ming Lee ; Chi-Man Koon ; Crystal Sao-Fong Cheung ; Ching-Po Lau ; Hei-Ming Ho ; Mavis Yuk-Ha Lee ; Shannon Wing-Ngor Au ; Christopher Hon-Ki Cheng ; Clara Bik-San Lau ; Stephen Kwok-Wing Tsui ; David Chi-Cheong Wan ; Mary Miu-Yee Waye ; Kam-Bo Wong ; Chun-Kwok Wong ; Christopher Wai-Kei Lam ; Ping-Chung Leung ; Kwok-Pui FungSource :
- Journal of ethnopharmacology [ 0378-8741 ] ; 2008.
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Abstract
Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4+ and CD8+ T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CLPro) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
| NO : | PASCAL 08-0330765 INIST |
|---|---|
| ET : | Immunomodulatory and anti-SARS activities of Houttuynia cordata |
| AU : | LAU (Kit-Man); LEE (Kin-Ming); KOON (Chi-Man); CHEUNG (Crystal Sao-Fong); LAU (Ching-Po); HO (Hei-Ming); LEE (Mavis Yuk-Ha); AU (Shannon Wing-Ngor); CHENG (Christopher Hon-Ki); LAU (Clara Bik-San); TSUI (Stephen Kwok-Wing); WAN (David Chi-Cheong); WAYE (Mary Miu-Yee); WONG (Kam-Bo); WONG (Chun-Kwok); LAM (Christopher Wai-Kei); LEUNG (Ping-Chung); FUNG (Kwok-Pui) |
| AF : | Institute of Chinese Medicine, The Chinese University of Hong Kong/Shatin/Hong-Kong (1 aut., 2 aut., 3 aut., 5 aut., 7 aut., 17 aut., 18 aut.); Department of Biochemistry. The Chinese University of Hong Kong/Shatin/Hong-Kong (4 aut., 6 aut., 8 aut., 9 aut., 11 aut., 12 aut., 13 aut., 14 aut., 18 aut.); School of Pharmacy, The Chinese University of Hong Kong/Shatin/Hong-Kong (10 aut.); Department of Chemical Pathology, The Chinese University of Hong Kong/Shatin/Hong-Kong (15 aut., 16 aut.) |
| DT : | Publication en série; Papier de recherche; Niveau analytique |
| SO : | Journal of ethnopharmacology; ISSN 0378-8741; Coden JOETD7; Irlande; Da. 2008; Vol. 118; No. 1; Pp. 79-85; Bibl. 3/4 p. |
| LA : | Anglais |
| EA : | Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4+ and CD8+ T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CLPro) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS. |
| CC : | 002B02A04 |
| FD : | Immunomodulateur; Virus syndrome respiratoire aigu sévère; DNA-directed RNA polymerase; Pharmacognosie; Plante médicinale; Origine végétale |
| FG : | Coronavirus; Coronaviridae; Nidovirales; Virus; Nucleotidyltransferases; Transferases; Enzyme |
| ED : | Immunomodulator; Severe acute respiratory syndrome virus; DNA-directed RNA polymerase; Pharmacognosy; Medicinal plant; Plant origin |
| EG : | Coronavirus; Coronaviridae; Nidovirales; Virus; Nucleotidyltransferases; Transferases; Enzyme |
| SD : | Inmunomodulador; Severe acute respiratory syndrome virus; DNA-directed RNA polymerase; Farmacognosia; Planta medicinal; Origen vegetal |
| LO : | INIST-18028.354000161782050120 |
| ID : | 08-0330765 |
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Pascal:08-0330765Le document en format XML
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The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name><affiliation><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name><affiliation><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0330765</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0330765 INIST</idno><idno type="RBID">Pascal:08-0330765</idno><idno type="wicri:Area/PascalFrancis/Corpus">000274</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immunomodulatory and anti-SARS activities of Houttuynia cordata</title><author><name sortKey="Lau, Kit Man" sort="Lau, Kit Man" uniqKey="Lau K" first="Kit-Man" last="Lau">Kit-Man Lau</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lee, Kin Ming" sort="Lee, Kin Ming" uniqKey="Lee K" first="Kin-Ming" last="Lee">Kin-Ming Lee</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Koon, Chi Man" sort="Koon, Chi Man" uniqKey="Koon C" first="Chi-Man" last="Koon">Chi-Man Koon</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cheung, Crystal Sao Fong" sort="Cheung, Crystal Sao Fong" uniqKey="Cheung C" first="Crystal Sao-Fong" last="Cheung">Crystal Sao-Fong Cheung</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lau, Ching Po" sort="Lau, Ching Po" uniqKey="Lau C" first="Ching-Po" last="Lau">Ching-Po Lau</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ho, Hei Ming" sort="Ho, Hei Ming" uniqKey="Ho H" first="Hei-Ming" last="Ho">Hei-Ming Ho</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lee, Mavis Yuk Ha" sort="Lee, Mavis Yuk Ha" uniqKey="Lee M" first="Mavis Yuk-Ha" last="Lee">Mavis Yuk-Ha Lee</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Au, Shannon Wing Ngor" sort="Au, Shannon Wing Ngor" uniqKey="Au S" first="Shannon Wing-Ngor" last="Au">Shannon Wing-Ngor Au</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cheng, Christopher Hon Ki" sort="Cheng, Christopher Hon Ki" uniqKey="Cheng C" first="Christopher Hon-Ki" last="Cheng">Christopher Hon-Ki Cheng</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lau, Clara Bik San" sort="Lau, Clara Bik San" uniqKey="Lau C" first="Clara Bik-San" last="Lau">Clara Bik-San Lau</name><affiliation><inist:fA14 i1="03"><s1>School of Pharmacy, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tsui, Stephen Kwok Wing" sort="Tsui, Stephen Kwok Wing" uniqKey="Tsui S" first="Stephen Kwok-Wing" last="Tsui">Stephen Kwok-Wing Tsui</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wan, David Chi Cheong" sort="Wan, David Chi Cheong" uniqKey="Wan D" first="David Chi-Cheong" last="Wan">David Chi-Cheong Wan</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Waye, Mary Miu Yee" sort="Waye, Mary Miu Yee" uniqKey="Waye M" first="Mary Miu-Yee" last="Waye">Mary Miu-Yee Waye</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wong, Kam Bo" sort="Wong, Kam Bo" uniqKey="Wong K" first="Kam-Bo" last="Wong">Kam-Bo Wong</name><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name><affiliation><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name><affiliation><inist:fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name><affiliation><inist:fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Journal of ethnopharmacology</title><title level="j" type="abbreviated">J. ethnopharmacol.</title><idno type="ISSN">0378-8741</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of ethnopharmacology</title><title level="j" type="abbreviated">J. ethnopharmacol.</title><idno type="ISSN">0378-8741</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA-directed RNA polymerase</term><term>Immunomodulator</term><term>Medicinal plant</term><term>Pharmacognosy</term><term>Plant origin</term><term>Severe acute respiratory syndrome virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Immunomodulateur</term><term>Virus syndrome respiratoire aigu sévère</term><term>DNA-directed RNA polymerase</term><term>Pharmacognosie</term><term>Plante médicinale</term><term>Origine végétale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4<sup>+</sup> and CD8<sup>+</sup> T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL<sup>Pro</sup>) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0378-8741</s0></fA01><fA02 i1="01"><s0>JOETD7</s0></fA02><fA03 i2="1"><s0>J. ethnopharmacol.</s0></fA03><fA05><s2>118</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Immunomodulatory and anti-SARS activities of Houttuynia cordata</s1></fA08><fA11 i1="01" i2="1"><s1>LAU (Kit-Man)</s1></fA11><fA11 i1="02" i2="1"><s1>LEE (Kin-Ming)</s1></fA11><fA11 i1="03" i2="1"><s1>KOON (Chi-Man)</s1></fA11><fA11 i1="04" i2="1"><s1>CHEUNG (Crystal Sao-Fong)</s1></fA11><fA11 i1="05" i2="1"><s1>LAU (Ching-Po)</s1></fA11><fA11 i1="06" i2="1"><s1>HO (Hei-Ming)</s1></fA11><fA11 i1="07" i2="1"><s1>LEE (Mavis Yuk-Ha)</s1></fA11><fA11 i1="08" i2="1"><s1>AU (Shannon Wing-Ngor)</s1></fA11><fA11 i1="09" i2="1"><s1>CHENG (Christopher Hon-Ki)</s1></fA11><fA11 i1="10" i2="1"><s1>LAU (Clara Bik-San)</s1></fA11><fA11 i1="11" i2="1"><s1>TSUI (Stephen Kwok-Wing)</s1></fA11><fA11 i1="12" i2="1"><s1>WAN (David Chi-Cheong)</s1></fA11><fA11 i1="13" i2="1"><s1>WAYE (Mary Miu-Yee)</s1></fA11><fA11 i1="14" i2="1"><s1>WONG (Kam-Bo)</s1></fA11><fA11 i1="15" i2="1"><s1>WONG (Chun-Kwok)</s1></fA11><fA11 i1="16" i2="1"><s1>LAM (Christopher Wai-Kei)</s1></fA11><fA11 i1="17" i2="1"><s1>LEUNG (Ping-Chung)</s1></fA11><fA11 i1="18" i2="1"><s1>FUNG (Kwok-Pui)</s1></fA11><fA14 i1="01"><s1>Institute of Chinese Medicine, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Biochemistry. The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="03"><s1>School of Pharmacy, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>10 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Chemical Pathology, The Chinese University of Hong Kong</s1><s2>Shatin</s2><s3>HKG</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></fA14><fA20><s1>79-85</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18028</s2><s5>354000161782050120</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>3/4 p.</s0></fA45><fA47 i1="01" i2="1"><s0>08-0330765</s0></fA47><fA60><s1>P</s1><s3>PR</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of ethnopharmacology</s0></fA64><fA66 i1="01"><s0>IRL</s0></fA66><fC01 i1="01" l="ENG"><s0>Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4<sup>+</sup> and CD8<sup>+</sup> T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL<sup>Pro</sup>) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02A04</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Immunomodulateur</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Immunomodulator</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Inmunomodulador</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0><s2>NW</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>DNA-directed RNA polymerase</s0><s2>FE</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>DNA-directed RNA polymerase</s0><s2>FE</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>DNA-directed RNA polymerase</s0><s2>FE</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Pharmacognosie</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Pharmacognosy</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Farmacognosia</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Plante médicinale</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Medicinal plant</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Planta medicinal</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Origine végétale</s0><s5>23</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Plant origin</s0><s5>23</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Origen vegetal</s0><s5>23</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Nucleotidyltransferases</s0><s2>FE</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Nucleotidyltransferases</s0><s2>FE</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Nucleotidyltransferases</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Transferases</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Transferases</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Transferases</s0><s2>FE</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Enzima</s0><s2>FE</s2></fC07><fN21><s1>210</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 08-0330765 INIST</NO><ET>Immunomodulatory and anti-SARS activities of Houttuynia cordata</ET><AU>LAU (Kit-Man); LEE (Kin-Ming); KOON (Chi-Man); CHEUNG (Crystal Sao-Fong); LAU (Ching-Po); HO (Hei-Ming); LEE (Mavis Yuk-Ha); AU (Shannon Wing-Ngor); CHENG (Christopher Hon-Ki); LAU (Clara Bik-San); TSUI (Stephen Kwok-Wing); WAN (David Chi-Cheong); WAYE (Mary Miu-Yee); WONG (Kam-Bo); WONG (Chun-Kwok); LAM (Christopher Wai-Kei); LEUNG (Ping-Chung); FUNG (Kwok-Pui)</AU><AF>Institute of Chinese Medicine, The Chinese University of Hong Kong/Shatin/Hong-Kong (1 aut., 2 aut., 3 aut., 5 aut., 7 aut., 17 aut., 18 aut.); Department of Biochemistry. The Chinese University of Hong Kong/Shatin/Hong-Kong (4 aut., 6 aut., 8 aut., 9 aut., 11 aut., 12 aut., 13 aut., 14 aut., 18 aut.); School of Pharmacy, The Chinese University of Hong Kong/Shatin/Hong-Kong (10 aut.); Department of Chemical Pathology, The Chinese University of Hong Kong/Shatin/Hong-Kong (15 aut., 16 aut.)</AF><DT>Publication en série; Papier de recherche; Niveau analytique</DT><SO>Journal of ethnopharmacology; ISSN 0378-8741; Coden JOETD7; Irlande; Da. 2008; Vol. 118; No. 1; Pp. 79-85; Bibl. 3/4 p.</SO><LA>Anglais</LA><EA>Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4<sup>+</sup> and CD8<sup>+</sup> T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL<sup>Pro</sup>) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.</EA><CC>002B02A04</CC><FD>Immunomodulateur; Virus syndrome respiratoire aigu sévère; DNA-directed RNA polymerase; Pharmacognosie; Plante médicinale; Origine végétale</FD><FG>Coronavirus; Coronaviridae; Nidovirales; Virus; Nucleotidyltransferases; Transferases; Enzyme</FG><ED>Immunomodulator; Severe acute respiratory syndrome virus; DNA-directed RNA polymerase; Pharmacognosy; Medicinal plant; Plant origin</ED><EG>Coronavirus; Coronaviridae; Nidovirales; Virus; Nucleotidyltransferases; Transferases; Enzyme</EG><SD>Inmunomodulador; Severe acute respiratory syndrome virus; DNA-directed RNA polymerase; Farmacognosia; Planta medicinal; Origen vegetal</SD><LO>INIST-18028.354000161782050120</LO><ID>08-0330765</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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