SrasV1, Ncbi, Merge, bibRecord, 001C59

Immunomodulatory and anti-SARS activities of Houttuynia cordata.

Identifieur interne : 001C59 ( Ncbi/Merge ); précédent : 001C58; suivant : 001C60

Immunomodulatory and anti-SARS activities of Houttuynia cordata.

Auteurs : Kit-Man Lau [République populaire de Chine] ; Kin-Ming Lee ; Chi-Man Koon ; Crystal Sao-Fong Cheung ; Ching-Po Lau ; Hei-Ming Ho ; Mavis Yuk-Ha Lee ; Shannon Wing-Ngor Au ; Christopher Hon-Ki Cheng ; Clara Bik-San Lau ; Stephen Kwok-Wing Tsui ; David Chi-Cheong Wan ; Mary Miu-Yee Waye ; Kam-Bo Wong ; Chun-Kwok Wong ; Christopher Wai-Kei Lam ; Ping-Chung Leung ; Kwok-Pui Fung

Source :

Journal of ethnopharmacology [ 0378-8741 ] ; 2008.

RBID : pubmed:18479853

Descripteurs français

KwdFr :
- Administration par voie orale, Animaux, Antiviraux (administration et posologie), Antiviraux (isolement et purification), Antiviraux (toxicité), Chine, Cytométrie en flux, Femelle, Lymphocytes T CD4+ (), Lymphocytes T CD4+ (métabolisme), Lymphocytes T CD8+ (), Lymphocytes T CD8+ (métabolisme), Médicaments issus de plantes chinoises (administration et posologie), Médicaments issus de plantes chinoises (toxicité), Prolifération cellulaire (), Rate (cytologie), Relation dose-effet des médicaments, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (traitement médicamenteux), Tests de toxicité aigüe, Virus du SRAS ().
MESH :
- administration et posologie : Antiviraux, Médicaments issus de plantes chinoises.
- cytologie : Rate.
- isolement et purification : Antiviraux.
- métabolisme : Lymphocytes T CD4+, Lymphocytes T CD8+.
- toxicité : Antiviraux, Médicaments issus de plantes chinoises.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- Administration par voie orale, Animaux, Chine, Cytométrie en flux, Femelle, Lymphocytes T CD4+, Lymphocytes T CD8+, Prolifération cellulaire, Relation dose-effet des médicaments, Souris, Souris de lignée BALB C, Tests de toxicité aigüe, Virus du SRAS.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Administration, Oral, Animals, Antiviral Agents (administration & dosage), Antiviral Agents (isolation & purification), Antiviral Agents (toxicity), CD4-Positive T-Lymphocytes (drug effects), CD4-Positive T-Lymphocytes (metabolism), CD8-Positive T-Lymphocytes (drug effects), CD8-Positive T-Lymphocytes (metabolism), Cell Proliferation (drug effects), China, Dose-Response Relationship, Drug, Drugs, Chinese Herbal (administration & dosage), Drugs, Chinese Herbal (toxicity), Female, Flow Cytometry, Mice, Mice, Inbred BALB C, SARS Virus (drug effects), Severe Acute Respiratory Syndrome (drug therapy), Spleen (cytology), Toxicity Tests, Acute.
MESH :
- chemical , administration & dosage : Antiviral Agents, Drugs, Chinese Herbal.
- chemical , isolation & purification : Antiviral Agents.
- chemical , toxicity : Antiviral Agents, Drugs, Chinese Herbal.
- geographic : China.
- cytology : Spleen.
- drug effects : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Proliferation, SARS Virus.
- drug therapy : Severe Acute Respiratory Syndrome.
- metabolism : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes.
- Administration, Oral, Animals, Dose-Response Relationship, Drug, Female, Flow Cytometry, Mice, Mice, Inbred BALB C, Toxicity Tests, Acute.

Abstract

Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae)(HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia.

DOI: 10.1016/j.jep.2008.03.018
PubMed: 18479853

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001B40
to stream PubMed, to step Curation: 001B40
to stream PubMed, to step Checkpoint: 001B14

Links to Exploration step

pubmed:18479853

Le document en format XML

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<term>Antiviral Agents (toxicity)</term>
<term>CD4-Positive T-Lymphocytes (drug effects)</term>
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<term>Drugs, Chinese Herbal (toxicity)</term>
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<term>Flow Cytometry</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>SARS Virus (drug effects)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Spleen (cytology)</term>
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<term>Antiviraux (toxicité)</term>
<term>Chine</term>
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<term>Femelle</term>
<term>Lymphocytes T CD4+ ()</term>
<term>Lymphocytes T CD4+ (métabolisme)</term>
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<term>Médicaments issus de plantes chinoises (toxicité)</term>
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<term>Souris de lignée BALB C</term>
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<term>Tests de toxicité aigüe</term>
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<term>Toxicity Tests, Acute</term>
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<term>Animaux</term>
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<term>Cytométrie en flux</term>
<term>Femelle</term>
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<term>Lymphocytes T CD8+</term>
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<term>Souris de lignée BALB C</term>
<term>Tests de toxicité aigüe</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae)(HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18479853</PMID>
<DateCompleted><Year>2008</Year>
<Month>11</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0378-8741</ISSN>
<JournalIssue CitedMedium="Print"><Volume>118</Volume>
<Issue>1</Issue>
<PubDate><Year>2008</Year>
<Month>Jun</Month>
<Day>19</Day>
</PubDate>
</JournalIssue>
<Title>Journal of ethnopharmacology</Title>
<ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation>
</Journal>
<ArticleTitle>Immunomodulatory and anti-SARS activities of Houttuynia cordata.</ArticleTitle>
<Pagination><MedlinePgn>79-85</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2008.03.018</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae)(HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia.</AbstractText>
<AbstractText Label="AIM OF THE STUDY" NlmCategory="OBJECTIVE">The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4(+) and CD8(+) T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL(pro)) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16 g/kg.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lau</LastName>
<ForeName>Kit-Man</ForeName>
<Initials>KM</Initials>
<AffiliationInfo><Affiliation>Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Kin-Ming</ForeName>
<Initials>KM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Koon</LastName>
<ForeName>Chi-Man</ForeName>
<Initials>CM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cheung</LastName>
<ForeName>Crystal Sao-Fong</ForeName>
<Initials>CS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lau</LastName>
<ForeName>Ching-Po</ForeName>
<Initials>CP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ho</LastName>
<ForeName>Hei-Ming</ForeName>
<Initials>HM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Mavis Yuk-Ha</ForeName>
<Initials>MY</Initials>
</Author>
<Author ValidYN="Y"><LastName>Au</LastName>
<ForeName>Shannon Wing-Ngor</ForeName>
<Initials>SW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cheng</LastName>
<ForeName>Christopher Hon-Ki</ForeName>
<Initials>CH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lau</LastName>
<ForeName>Clara Bik-San</ForeName>
<Initials>CB</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tsui</LastName>
<ForeName>Stephen Kwok-Wing</ForeName>
<Initials>SK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wan</LastName>
<ForeName>David Chi-Cheong</ForeName>
<Initials>DC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Waye</LastName>
<ForeName>Mary Miu-Yee</ForeName>
<Initials>MM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wong</LastName>
<ForeName>Kam-Bo</ForeName>
<Initials>KB</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wong</LastName>
<ForeName>Chun-Kwok</ForeName>
<Initials>CK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lam</LastName>
<ForeName>Christopher Wai-Kei</ForeName>
<Initials>CW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Leung</LastName>
<ForeName>Ping-Chung</ForeName>
<Initials>PC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fung</LastName>
<ForeName>Kwok-Pui</ForeName>
<Initials>KP</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2008</Year>
<Month>03</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Ireland</Country>
<MedlineTA>J Ethnopharmacol</MedlineTA>
<NlmUniqueID>7903310</NlmUniqueID>
<ISSNLinking>0378-8741</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C442781">plant extract, Houttuynia cordata</NameOfSubstance>
</Chemical>
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Immunomodulatory and anti-SARS activities of Houttuynia cordata.

Immunomodulatory and anti-SARS activities of Houttuynia cordata.

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