The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.
Identifieur interne : 001834 ( Main/Curation ); précédent : 001833; suivant : 001835The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.
Auteurs : Zhilin Ren [République populaire de Chine] ; Liming Yan ; Ning Zhang ; Yu Guo ; Cheng Yang ; Zhiyong Lou ; Zihe RaoSource :
- Protein & cell [ 1674-8018 ] ; 2013.
Descripteurs français
- KwdFr :
- Cysteine endopeptidases (métabolisme), Humains, Inhibiteurs de protéases (), Inhibiteurs de protéases (métabolisme), Inhibiteurs de protéases (pharmacologie), Isoxazoles (), Isoxazoles (pharmacologie), Protéines virales (antagonistes et inhibiteurs), Protéines virales (métabolisme), Pyrrolidones (), Pyrrolidones (pharmacologie), Rhinovirus (), Sites de fixation, Structure tertiaire des protéines, Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (enzymologie).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- métabolisme : Cysteine endopeptidases, Inhibiteurs de protéases, Protéines virales.
- pharmacologie : Inhibiteurs de protéases, Isoxazoles, Pyrrolidones.
- virologie : Syndrome respiratoire aigu sévère.
- Humains, Inhibiteurs de protéases, Isoxazoles, Pyrrolidones, Rhinovirus, Sites de fixation, Structure tertiaire des protéines, Virus du SRAS.
English descriptors
- KwdEn :
- Binding Sites, Cysteine Endopeptidases (metabolism), Humans, Isoxazoles (chemistry), Isoxazoles (pharmacology), Protease Inhibitors (chemistry), Protease Inhibitors (metabolism), Protease Inhibitors (pharmacology), Protein Structure, Tertiary, Pyrrolidinones (chemistry), Pyrrolidinones (pharmacology), Rhinovirus (drug effects), SARS Virus (drug effects), SARS Virus (enzymology), Severe Acute Respiratory Syndrome (virology), Viral Proteins (antagonists & inhibitors), Viral Proteins (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemistry : Isoxazoles, Protease Inhibitors, Pyrrolidinones.
- chemical , metabolism : Cysteine Endopeptidases, Protease Inhibitors, Viral Proteins.
- chemical , pharmacology : Isoxazoles, Protease Inhibitors, Pyrrolidinones.
- drug effects : Rhinovirus, SARS Virus.
- enzymology : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Binding Sites, Humans, Protein Structure, Tertiary.
DOI: 10.1007/s13238-013-2841-3
PubMed: 23549610
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pubmed:23549610Le document en format XML
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<term>Protease Inhibitors (pharmacology)</term>
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<term>Pyrrolidinones (pharmacology)</term>
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<term>SARS Virus (enzymology)</term>
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