The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.
Identifieur interne : 001229 ( PubMed/Corpus ); précédent : 001228; suivant : 001230The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.
Auteurs : Zhilin Ren ; Liming Yan ; Ning Zhang ; Yu Guo ; Cheng Yang ; Zhiyong Lou ; Zihe RaoSource :
- Protein & cell [ 1674-8018 ] ; 2013.
English descriptors
- KwdEn :
- Binding Sites, Cysteine Endopeptidases (metabolism), Humans, Isoxazoles (chemistry), Isoxazoles (pharmacology), Protease Inhibitors (chemistry), Protease Inhibitors (metabolism), Protease Inhibitors (pharmacology), Protein Structure, Tertiary, Pyrrolidinones (chemistry), Pyrrolidinones (pharmacology), Rhinovirus (drug effects), SARS Virus (drug effects), SARS Virus (enzymology), Severe Acute Respiratory Syndrome (virology), Viral Proteins (antagonists & inhibitors), Viral Proteins (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemistry : Isoxazoles, Protease Inhibitors, Pyrrolidinones.
- chemical , metabolism : Cysteine Endopeptidases, Protease Inhibitors, Viral Proteins.
- chemical , pharmacology : Isoxazoles, Protease Inhibitors, Pyrrolidinones.
- drug effects : Rhinovirus, SARS Virus.
- enzymology : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Binding Sites, Humans, Protein Structure, Tertiary.
DOI: 10.1007/s13238-013-2841-3
PubMed: 23549610
Links to Exploration step
pubmed:23549610Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.</title>
<author><name sortKey="Ren, Zhilin" sort="Ren, Zhilin" uniqKey="Ren Z" first="Zhilin" last="Ren">Zhilin Ren</name>
<affiliation><nlm:affiliation>College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yan, Liming" sort="Yan, Liming" uniqKey="Yan L" first="Liming" last="Yan">Liming Yan</name>
</author>
<author><name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name>
</author>
<author><name sortKey="Guo, Yu" sort="Guo, Yu" uniqKey="Guo Y" first="Yu" last="Guo">Yu Guo</name>
</author>
<author><name sortKey="Yang, Cheng" sort="Yang, Cheng" uniqKey="Yang C" first="Cheng" last="Yang">Cheng Yang</name>
</author>
<author><name sortKey="Lou, Zhiyong" sort="Lou, Zhiyong" uniqKey="Lou Z" first="Zhiyong" last="Lou">Zhiyong Lou</name>
</author>
<author><name sortKey="Rao, Zihe" sort="Rao, Zihe" uniqKey="Rao Z" first="Zihe" last="Rao">Zihe Rao</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23549610</idno>
<idno type="pmid">23549610</idno>
<idno type="doi">10.1007/s13238-013-2841-3</idno>
<idno type="wicri:Area/PubMed/Corpus">001229</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001229</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.</title>
<author><name sortKey="Ren, Zhilin" sort="Ren, Zhilin" uniqKey="Ren Z" first="Zhilin" last="Ren">Zhilin Ren</name>
<affiliation><nlm:affiliation>College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yan, Liming" sort="Yan, Liming" uniqKey="Yan L" first="Liming" last="Yan">Liming Yan</name>
</author>
<author><name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name>
</author>
<author><name sortKey="Guo, Yu" sort="Guo, Yu" uniqKey="Guo Y" first="Yu" last="Guo">Yu Guo</name>
</author>
<author><name sortKey="Yang, Cheng" sort="Yang, Cheng" uniqKey="Yang C" first="Cheng" last="Yang">Cheng Yang</name>
</author>
<author><name sortKey="Lou, Zhiyong" sort="Lou, Zhiyong" uniqKey="Lou Z" first="Zhiyong" last="Lou">Zhiyong Lou</name>
</author>
<author><name sortKey="Rao, Zihe" sort="Rao, Zihe" uniqKey="Rao Z" first="Zihe" last="Rao">Zihe Rao</name>
</author>
</analytic>
<series><title level="j">Protein & cell</title>
<idno type="eISSN">1674-8018</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Binding Sites</term>
<term>Cysteine Endopeptidases (metabolism)</term>
<term>Humans</term>
<term>Isoxazoles (chemistry)</term>
<term>Isoxazoles (pharmacology)</term>
<term>Protease Inhibitors (chemistry)</term>
<term>Protease Inhibitors (metabolism)</term>
<term>Protease Inhibitors (pharmacology)</term>
<term>Protein Structure, Tertiary</term>
<term>Pyrrolidinones (chemistry)</term>
<term>Pyrrolidinones (pharmacology)</term>
<term>Rhinovirus (drug effects)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (enzymology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
<term>Viral Proteins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Isoxazoles</term>
<term>Protease Inhibitors</term>
<term>Pyrrolidinones</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Endopeptidases</term>
<term>Protease Inhibitors</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Isoxazoles</term>
<term>Protease Inhibitors</term>
<term>Pyrrolidinones</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Rhinovirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Binding Sites</term>
<term>Humans</term>
<term>Protein Structure, Tertiary</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23549610</PMID>
<DateCompleted><Year>2013</Year>
<Month>09</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1674-8018</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>4</Volume>
<Issue>4</Issue>
<PubDate><Year>2013</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Protein & cell</Title>
<ISOAbbreviation>Protein Cell</ISOAbbreviation>
</Journal>
<ArticleTitle>The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.</ArticleTitle>
<Pagination><MedlinePgn>248-50</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s13238-013-2841-3</ELocationID>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ren</LastName>
<ForeName>Zhilin</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Liming</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Ning</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Cheng</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lou</LastName>
<ForeName>Zhiyong</ForeName>
<Initials>Z</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rao</LastName>
<ForeName>Zihe</ForeName>
<Initials>Z</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Protein Cell</MedlineTA>
<NlmUniqueID>101532368</NlmUniqueID>
<ISSNLinking>1674-800X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007555">Isoxazoles</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011480">Protease Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011760">Pyrrolidinones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber>
<NameOfSubstance UI="C099456">3C-like proteinase, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber>
<NameOfSubstance UI="D003546">Cysteine Endopeptidases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>RGE5K1Q5QW</RegistryNumber>
<NameOfSubstance UI="C118874">rupintrivir</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003546" MajorTopicYN="N">Cysteine Endopeptidases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007555" MajorTopicYN="N">Isoxazoles</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011480" MajorTopicYN="N">Protease Inhibitors</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017434" MajorTopicYN="N">Protein Structure, Tertiary</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011760" MajorTopicYN="N">Pyrrolidinones</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012229" MajorTopicYN="N">Rhinovirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>4</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
<Month>4</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>9</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23549610</ArticleId>
<ArticleId IdType="doi">10.1007/s13238-013-2841-3</ArticleId>
<ArticleId IdType="pmc">PMC4875521</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Virol. 2012 Nov;86(21):11906-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22933277</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Biol. 2005 Oct;3(10):e324</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16128623</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2005 Sep 1;13(17):5240-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15994085</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Top Med Chem. 2006;6(4):361-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16611148</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Protein Cell. 2010 Feb;1(2):198-204</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21203988</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2000 Apr;81(Pt 4):853-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10725411</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 Jun 13;300(5626):1763-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12746549</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14585926</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2008 Sep;82(17):8647-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18562531</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2008 Mar;82(5):2515-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18094151</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2002 Jul 1;21(13):3213-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12093723</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Mar 20;284(12):7646-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19144641</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001229 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001229 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:23549610 |texte= The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:23549610" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |