Increased Morbidity in Early Childhood Among HIV-exposed Uninfected Children in Uganda is Associated with Breastfeeding Duration
Identifieur interne : 001717 ( Pmc/Corpus ); précédent : 001716; suivant : 001718Increased Morbidity in Early Childhood Among HIV-exposed Uninfected Children in Uganda is Associated with Breastfeeding Duration
Auteurs : Carina Marquez ; Jaffer Okiring ; Gabriel Chamie ; Theodore D. Ruel ; Jane Achan ; Abel Kakuru ; Moses R. Kamya ; Edwin D. Charlebois ; Diane V. Havlir ; Grant DorseySource :
- Journal of Tropical Pediatrics [ 0142-6338 ] ; 2014.
Abstract
Human immunodeficiency virus (HIV)-exposed uninfected children (HEU) have an increased risk of morbidity and mortality compared with HIV-unexposed uninfected children (HUU); however, prior studies have not fully accounted for the role of both breastfeeding and age on this association. In this cohort of HEU and HUU in Uganda, non-breastfeeding HEU, from 6–11 months compared with non-breastfeeding HUU had a higher risk of hospitalizations [relative risk (RR): 10.1, 95% confidence interval (CI): 3.70–27.6], severe febrile illness (RR: 3.84, 95% CI: 2.06–7.17), severe diarrhea (RR: 6.37, 95% CI: 2.32–17.4) and severe malnutrition (RR: 18.4, 95% CI: 4.68–72.0). There were no differences between morbidity outcomes between breastfeeding HEU and HUU children, aged 6–11 months. In the 12–24 month age group, the only difference in morbidity outcomes among non-breast feeding children was an increased risk of severe malnutrition for HEU. These data suggest that the increased risk of morbidity among HEU aged 6–11 years is partially explained by early cessation of breastfeeding.
Url:
DOI: 10.1093/tropej/fmu045
PubMed: 25145704
PubMed Central: 4303769
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Ruel</name><affiliation><nlm:aff id="fmu045-AFF3">Division of Infectious Diseases, Department of Pediatrics, University of California, San Francisco, CA 94143, USA</nlm:aff></affiliation></author><author><name sortKey="Achan, Jane" sort="Achan, Jane" uniqKey="Achan J" first="Jane" last="Achan">Jane Achan</name><affiliation><nlm:aff id="fmu045-AFF4">Department of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Kakuru, Abel" sort="Kakuru, Abel" uniqKey="Kakuru A" first="Abel" last="Kakuru">Abel Kakuru</name><affiliation><nlm:aff id="fmu045-AFF2">Infectious Diseases Research Collaboration, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Kamya, Moses R" sort="Kamya, Moses R" uniqKey="Kamya M" first="Moses R." last="Kamya">Moses R. Kamya</name><affiliation><nlm:aff id="fmu045-AFF5">Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Charlebois, Edwin D" sort="Charlebois, Edwin D" uniqKey="Charlebois E" first="Edwin D." last="Charlebois">Edwin D. Charlebois</name><affiliation><nlm:aff id="fmu045-AFF6">Center for AIDS Prevention, University of California, San Francisco, CA 94105, USA</nlm:aff></affiliation></author><author><name sortKey="Havlir, Diane V" sort="Havlir, Diane V" uniqKey="Havlir D" first="Diane V." last="Havlir">Diane V. Havlir</name><affiliation><nlm:aff id="fmu045-AFF1">Division of HIV/AIDS, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA</nlm:aff></affiliation></author><author><name sortKey="Dorsey, Grant" sort="Dorsey, Grant" uniqKey="Dorsey G" first="Grant" last="Dorsey">Grant Dorsey</name><affiliation><nlm:aff id="fmu045-AFF7">Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25145704</idno><idno type="pmc">4303769</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303769</idno><idno type="RBID">PMC:4303769</idno><idno type="doi">10.1093/tropej/fmu045</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001717</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001717</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Increased Morbidity in Early Childhood Among HIV-exposed Uninfected Children in Uganda is Associated with Breastfeeding Duration</title><author><name sortKey="Marquez, Carina" sort="Marquez, Carina" uniqKey="Marquez C" first="Carina" last="Marquez">Carina Marquez</name><affiliation><nlm:aff id="fmu045-AFF1">Division of HIV/AIDS, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA</nlm:aff></affiliation></author><author><name sortKey="Okiring, Jaffer" sort="Okiring, Jaffer" uniqKey="Okiring J" first="Jaffer" last="Okiring">Jaffer Okiring</name><affiliation><nlm:aff id="fmu045-AFF2">Infectious Diseases Research Collaboration, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Chamie, Gabriel" sort="Chamie, Gabriel" uniqKey="Chamie G" first="Gabriel" last="Chamie">Gabriel Chamie</name><affiliation><nlm:aff id="fmu045-AFF1">Division of HIV/AIDS, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA</nlm:aff></affiliation></author><author><name sortKey="Ruel, Theodore D" sort="Ruel, Theodore D" uniqKey="Ruel T" first="Theodore D." last="Ruel">Theodore D. Ruel</name><affiliation><nlm:aff id="fmu045-AFF3">Division of Infectious Diseases, Department of Pediatrics, University of California, San Francisco, CA 94143, USA</nlm:aff></affiliation></author><author><name sortKey="Achan, Jane" sort="Achan, Jane" uniqKey="Achan J" first="Jane" last="Achan">Jane Achan</name><affiliation><nlm:aff id="fmu045-AFF4">Department of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Kakuru, Abel" sort="Kakuru, Abel" uniqKey="Kakuru A" first="Abel" last="Kakuru">Abel Kakuru</name><affiliation><nlm:aff id="fmu045-AFF2">Infectious Diseases Research Collaboration, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Kamya, Moses R" sort="Kamya, Moses R" uniqKey="Kamya M" first="Moses R." last="Kamya">Moses R. Kamya</name><affiliation><nlm:aff id="fmu045-AFF5">Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda</nlm:aff></affiliation></author><author><name sortKey="Charlebois, Edwin D" sort="Charlebois, Edwin D" uniqKey="Charlebois E" first="Edwin D." last="Charlebois">Edwin D. Charlebois</name><affiliation><nlm:aff id="fmu045-AFF6">Center for AIDS Prevention, University of California, San Francisco, CA 94105, USA</nlm:aff></affiliation></author><author><name sortKey="Havlir, Diane V" sort="Havlir, Diane V" uniqKey="Havlir D" first="Diane V." last="Havlir">Diane V. Havlir</name><affiliation><nlm:aff id="fmu045-AFF1">Division of HIV/AIDS, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA</nlm:aff></affiliation></author><author><name sortKey="Dorsey, Grant" sort="Dorsey, Grant" uniqKey="Dorsey G" first="Grant" last="Dorsey">Grant Dorsey</name><affiliation><nlm:aff id="fmu045-AFF7">Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Tropical Pediatrics</title><idno type="ISSN">0142-6338</idno><idno type="eISSN">1465-3664</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Human immunodeficiency virus (HIV)-exposed uninfected children (HEU) have an increased risk of morbidity and mortality compared with HIV-unexposed uninfected children (HUU); however, prior studies have not fully accounted for the role of both breastfeeding and age on this association. In this cohort of HEU and HUU in Uganda, non-breastfeeding HEU, from 6–11 months compared with non-breastfeeding HUU had a higher risk of hospitalizations [relative risk (RR): 10.1, 95% confidence interval (CI): 3.70–27.6], severe febrile illness (RR: 3.84, 95% CI: 2.06–7.17), severe diarrhea (RR: 6.37, 95% CI: 2.32–17.4) and severe malnutrition (RR: 18.4, 95% CI: 4.68–72.0). There were no differences between morbidity outcomes between breastfeeding HEU and HUU children, aged 6–11 months. In the 12–24 month age group, the only difference in morbidity outcomes among non-breast feeding children was an increased risk of severe malnutrition for HEU. These data suggest that the increased risk of morbidity among HEU aged 6–11 years is partially explained by early cessation of breastfeeding.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Trop Pediatr</journal-id><journal-id journal-id-type="iso-abbrev">J. Trop. Pediatr</journal-id><journal-id journal-id-type="publisher-id">tropej</journal-id><journal-id journal-id-type="hwp">tropej</journal-id><journal-title-group><journal-title>Journal of Tropical Pediatrics</journal-title></journal-title-group><issn pub-type="ppub">0142-6338</issn><issn pub-type="epub">1465-3664</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25145704</article-id><article-id pub-id-type="pmc">4303769</article-id><article-id pub-id-type="doi">10.1093/tropej/fmu045</article-id><article-id pub-id-type="publisher-id">fmu045</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Papers</subject></subj-group></article-categories><title-group><article-title>Increased Morbidity in Early Childhood Among HIV-exposed Uninfected Children in Uganda is Associated with Breastfeeding Duration</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Marquez</surname><given-names>Carina</given-names></name><xref ref-type="aff" rid="fmu045-AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Okiring</surname><given-names>Jaffer</given-names></name><xref ref-type="aff" rid="fmu045-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chamie</surname><given-names>Gabriel</given-names></name><xref ref-type="aff" rid="fmu045-AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ruel</surname><given-names>Theodore D.</given-names></name><xref ref-type="aff" rid="fmu045-AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Achan</surname><given-names>Jane</given-names></name><xref ref-type="aff" rid="fmu045-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kakuru</surname><given-names>Abel</given-names></name><xref ref-type="aff" rid="fmu045-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kamya</surname><given-names>Moses R.</given-names></name><xref ref-type="aff" rid="fmu045-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Charlebois</surname><given-names>Edwin D.</given-names></name><xref ref-type="aff" rid="fmu045-AFF6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Havlir</surname><given-names>Diane V.</given-names></name><xref ref-type="aff" rid="fmu045-AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dorsey</surname><given-names>Grant</given-names></name><xref ref-type="aff" rid="fmu045-AFF7"><sup>7</sup></xref></contrib><aff id="fmu045-AFF1"><sup>1</sup>Division of HIV/AIDS, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA</aff><aff id="fmu045-AFF2"><sup>2</sup>Infectious Diseases Research Collaboration, Kampala, Uganda</aff><aff id="fmu045-AFF3"><sup>3</sup>Division of Infectious Diseases, Department of Pediatrics, University of California, San Francisco, CA 94143, USA</aff><aff id="fmu045-AFF4"><sup>4</sup>Department of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda</aff><aff id="fmu045-AFF5"><sup>5</sup>Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda</aff><aff id="fmu045-AFF6"><sup>6</sup>Center for AIDS Prevention, University of California, San Francisco, CA 94105, USA</aff><aff id="fmu045-AFF7"><sup>7</sup>Division of Infectious Diseases, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA</aff></contrib-group><author-notes><corresp>Correspondence: Carina Marquez, Division of HIV/AIDS, San Francisco General Hospital, 995 Potrero Ave, Building 80, Room 424, San Francisco CA 94110. UCSF Box 0874, San Francisco CA 94103, USA. Tel: <phone>415-476-4082 x 331</phone>. Fax: <fax>415-476-6953</fax>. E-mail <<email>carina.marquez@ucsf.edu</email>>.</corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>21</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>60</volume><issue>6</issue><fpage>434</fpage><lpage>441</lpage><permissions><copyright-statement>© The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>Human immunodeficiency virus (HIV)-exposed uninfected children (HEU) have an increased risk of morbidity and mortality compared with HIV-unexposed uninfected children (HUU); however, prior studies have not fully accounted for the role of both breastfeeding and age on this association. In this cohort of HEU and HUU in Uganda, non-breastfeeding HEU, from 6–11 months compared with non-breastfeeding HUU had a higher risk of hospitalizations [relative risk (RR): 10.1, 95% confidence interval (CI): 3.70–27.6], severe febrile illness (RR: 3.84, 95% CI: 2.06–7.17), severe diarrhea (RR: 6.37, 95% CI: 2.32–17.4) and severe malnutrition (RR: 18.4, 95% CI: 4.68–72.0). There were no differences between morbidity outcomes between breastfeeding HEU and HUU children, aged 6–11 months. In the 12–24 month age group, the only difference in morbidity outcomes among non-breast feeding children was an increased risk of severe malnutrition for HEU. These data suggest that the increased risk of morbidity among HEU aged 6–11 years is partially explained by early cessation of breastfeeding.</p></abstract><kwd-group><kwd>Africa</kwd><kwd>HIV</kwd><kwd>HIV-exposed</kwd><kwd>Breastfeeding</kwd><kwd>Morbidity</kwd><kwd>Mortality</kwd></kwd-group><counts><page-count count="8"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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