Effect of Multivitamin Supplementation on the Neurodevelopment of HIV-Exposed Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Identifieur interne : 001716 ( Pmc/Corpus ); précédent : 001715; suivant : 001717Effect of Multivitamin Supplementation on the Neurodevelopment of HIV-Exposed Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Auteurs : Karim P. Manji ; Christine M. Mcdonald ; Roland Kupka ; Ronald J. Bosch ; Rodrick Kisenge ; Said Aboud ; David C. Bellinger ; Wafaie W. Fawzi ; Christopher P. DugganSource :
- Journal of Tropical Pediatrics [ 0142-6338 ] ; 2014.
Abstract
Background: Micronutrient deficiencies and
Objective: To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants.
Methods: A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months.
Results: Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = −0.01, 0.78,
Conclusion: Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months.
Url:
DOI: 10.1093/tropej/fmu011
PubMed: 24567309
PubMed Central: 4176040
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Multivitamin Supplementation on the Neurodevelopment of HIV-Exposed Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial</title><author><name sortKey="Manji, Karim P" sort="Manji, Karim P" uniqKey="Manji K" first="Karim P." last="Manji">Karim P. Manji</name><affiliation><nlm:aff id="fmu011-AFF1">Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF11">*Karim P. Manji and Christine M. McDonald are joint first authors</nlm:aff></affiliation></author><author><name sortKey="Mcdonald, Christine M" sort="Mcdonald, Christine M" uniqKey="Mcdonald C" first="Christine M." last="Mcdonald">Christine M. Mcdonald</name><affiliation><nlm:aff id="fmu011-AFF2">Division of Gastroenterology, Hepatology and Nutrition, Boston Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF11">*Karim P. Manji and Christine M. McDonald are joint first authors</nlm:aff></affiliation></author><author><name sortKey="Kupka, Roland" sort="Kupka, Roland" uniqKey="Kupka R" first="Roland" last="Kupka">Roland Kupka</name><affiliation><nlm:aff id="fmu011-AFF3">UNICEF West and Central Africa Regional Office, Immeuble Maimouna III, Yoff, Dakar, Senegal</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF4">Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Bosch, Ronald J" sort="Bosch, Ronald J" uniqKey="Bosch R" first="Ronald J." last="Bosch">Ronald J. Bosch</name><affiliation><nlm:aff id="fmu011-AFF5">Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kisenge, Rodrick" sort="Kisenge, Rodrick" uniqKey="Kisenge R" first="Rodrick" last="Kisenge">Rodrick Kisenge</name><affiliation><nlm:aff id="fmu011-AFF1">Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania</nlm:aff></affiliation></author><author><name sortKey="Aboud, Said" sort="Aboud, Said" uniqKey="Aboud S" first="Said" last="Aboud">Said Aboud</name><affiliation><nlm:aff id="fmu011-AFF6">Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania</nlm:aff></affiliation></author><author><name sortKey="Bellinger, David C" sort="Bellinger, David C" uniqKey="Bellinger D" first="David C." last="Bellinger">David C. Bellinger</name><affiliation><nlm:aff id="fmu011-AFF7">Department of Neurology, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF8">Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W." last="Fawzi">Wafaie W. Fawzi</name><affiliation><nlm:aff id="fmu011-AFF4">Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF9">Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF10">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Duggan, Christopher P" sort="Duggan, Christopher P" uniqKey="Duggan C" first="Christopher P." last="Duggan">Christopher P. Duggan</name><affiliation><nlm:aff id="fmu011-AFF2">Division of Gastroenterology, Hepatology and Nutrition, Boston Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF4">Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24567309</idno><idno type="pmc">4176040</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176040</idno><idno type="RBID">PMC:4176040</idno><idno type="doi">10.1093/tropej/fmu011</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001716</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001716</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Multivitamin Supplementation on the Neurodevelopment of HIV-Exposed Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial</title><author><name sortKey="Manji, Karim P" sort="Manji, Karim P" uniqKey="Manji K" first="Karim P." last="Manji">Karim P. Manji</name><affiliation><nlm:aff id="fmu011-AFF1">Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF11">*Karim P. Manji and Christine M. McDonald are joint first authors</nlm:aff></affiliation></author><author><name sortKey="Mcdonald, Christine M" sort="Mcdonald, Christine M" uniqKey="Mcdonald C" first="Christine M." last="Mcdonald">Christine M. Mcdonald</name><affiliation><nlm:aff id="fmu011-AFF2">Division of Gastroenterology, Hepatology and Nutrition, Boston Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF11">*Karim P. Manji and Christine M. McDonald are joint first authors</nlm:aff></affiliation></author><author><name sortKey="Kupka, Roland" sort="Kupka, Roland" uniqKey="Kupka R" first="Roland" last="Kupka">Roland Kupka</name><affiliation><nlm:aff id="fmu011-AFF3">UNICEF West and Central Africa Regional Office, Immeuble Maimouna III, Yoff, Dakar, Senegal</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF4">Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Bosch, Ronald J" sort="Bosch, Ronald J" uniqKey="Bosch R" first="Ronald J." last="Bosch">Ronald J. Bosch</name><affiliation><nlm:aff id="fmu011-AFF5">Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Kisenge, Rodrick" sort="Kisenge, Rodrick" uniqKey="Kisenge R" first="Rodrick" last="Kisenge">Rodrick Kisenge</name><affiliation><nlm:aff id="fmu011-AFF1">Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania</nlm:aff></affiliation></author><author><name sortKey="Aboud, Said" sort="Aboud, Said" uniqKey="Aboud S" first="Said" last="Aboud">Said Aboud</name><affiliation><nlm:aff id="fmu011-AFF6">Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania</nlm:aff></affiliation></author><author><name sortKey="Bellinger, David C" sort="Bellinger, David C" uniqKey="Bellinger D" first="David C." last="Bellinger">David C. Bellinger</name><affiliation><nlm:aff id="fmu011-AFF7">Department of Neurology, Boston Children’s Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF8">Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W." last="Fawzi">Wafaie W. Fawzi</name><affiliation><nlm:aff id="fmu011-AFF4">Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF9">Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF10">Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Duggan, Christopher P" sort="Duggan, Christopher P" uniqKey="Duggan C" first="Christopher P." last="Duggan">Christopher P. Duggan</name><affiliation><nlm:aff id="fmu011-AFF2">Division of Gastroenterology, Hepatology and Nutrition, Boston Hospital, Boston, MA 02115, USA</nlm:aff></affiliation><affiliation><nlm:aff id="fmu011-AFF4">Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Tropical Pediatrics</title><idno type="ISSN">0142-6338</idno><idno type="eISSN">1465-3664</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Background: Micronutrient deficiencies and <italic>in utero</italic> exposure to HIV may impair infant neurodevelopment.</p><p>Objective: To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants.</p><p>Methods: A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months.</p><p>Results: Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = −0.01, 0.78, <italic>p</italic> = 0.06).</p><p>Conclusion: Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Trop Pediatr</journal-id><journal-id journal-id-type="iso-abbrev">J. Trop. Pediatr</journal-id><journal-id journal-id-type="publisher-id">tropej</journal-id><journal-id journal-id-type="hwp">tropej</journal-id><journal-title-group><journal-title>Journal of Tropical Pediatrics</journal-title></journal-title-group><issn pub-type="ppub">0142-6338</issn><issn pub-type="epub">1465-3664</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24567309</article-id><article-id pub-id-type="pmc">4176040</article-id><article-id pub-id-type="doi">10.1093/tropej/fmu011</article-id><article-id pub-id-type="publisher-id">fmu011</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Papers</subject></subj-group></article-categories><title-group><article-title>Effect of Multivitamin Supplementation on the Neurodevelopment of HIV-Exposed Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Manji</surname><given-names>Karim P.</given-names></name><xref ref-type="aff" rid="fmu011-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="fmu011-AFF11">*</xref></contrib><contrib contrib-type="author"><name><surname>McDonald</surname><given-names>Christine M.</given-names></name><xref ref-type="aff" rid="fmu011-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="fmu011-AFF11">*</xref></contrib><contrib contrib-type="author"><name><surname>Kupka</surname><given-names>Roland</given-names></name><xref ref-type="aff" rid="fmu011-AFF3"><sup>3</sup></xref><xref ref-type="aff" rid="fmu011-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bosch</surname><given-names>Ronald J.</given-names></name><xref ref-type="aff" rid="fmu011-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kisenge</surname><given-names>Rodrick</given-names></name><xref ref-type="aff" rid="fmu011-AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Aboud</surname><given-names>Said</given-names></name><xref ref-type="aff" rid="fmu011-AFF6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bellinger</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="fmu011-AFF7"><sup>7</sup></xref><xref ref-type="aff" rid="fmu011-AFF8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fawzi</surname><given-names>Wafaie W.</given-names></name><xref ref-type="aff" rid="fmu011-AFF4"><sup>4</sup></xref><xref ref-type="aff" rid="fmu011-AFF9"><sup>9</sup></xref><xref ref-type="aff" rid="fmu011-AFF10"><sup>10</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Duggan</surname><given-names>Christopher P.</given-names></name><xref ref-type="aff" rid="fmu011-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="fmu011-AFF4"><sup>4</sup></xref></contrib><aff id="fmu011-AFF1"><sup>1</sup>Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania</aff><aff id="fmu011-AFF2"><sup>2</sup>Division of Gastroenterology, Hepatology and Nutrition, Boston Hospital, Boston, MA 02115, USA</aff><aff id="fmu011-AFF3"><sup>3</sup>UNICEF West and Central Africa Regional Office, Immeuble Maimouna III, Yoff, Dakar, Senegal</aff><aff id="fmu011-AFF4"><sup>4</sup>Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA</aff><aff id="fmu011-AFF5"><sup>5</sup>Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA</aff><aff id="fmu011-AFF6"><sup>6</sup>Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania</aff><aff id="fmu011-AFF7"><sup>7</sup>Department of Neurology, Boston Children’s Hospital, Boston, MA 02115, USA</aff><aff id="fmu011-AFF8"><sup>8</sup>Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA</aff><aff id="fmu011-AFF9"><sup>9</sup>Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115, USA</aff><aff id="fmu011-AFF10"><sup>10</sup>Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA</aff><aff id="fmu011-AFF11">*Karim P. Manji and Christine M. McDonald are joint first authors</aff></contrib-group><author-notes><corresp>Correspondence: Christopher Duggan, Center for Nutrition, Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, 300 Longwood Ave., Boston, MA 02115, USA. Tel: <phone>+1 617 355 7612</phone>. Fax: <fax>+1 617 730 0494</fax>. E-mail <<email>christopher.duggan@childrens.harvard.edu</email>>.</corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>24</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>8</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>60</volume><issue>4</issue><fpage>279</fpage><lpage>286</lpage><permissions><copyright-statement>© The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>Background: Micronutrient deficiencies and <italic>in utero</italic> exposure to HIV may impair infant neurodevelopment.</p><p>Objective: To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants.</p><p>Methods: A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months.</p><p>Results: Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = −0.01, 0.78, <italic>p</italic> = 0.06).</p><p>Conclusion: Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months.</p></abstract><kwd-group><kwd>Multivitamins</kwd><kwd>infant development</kwd><kwd>HIV</kwd></kwd-group><counts><page-count count="8"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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