Time-independent Maternal and Infant Factors and Time-dependent Infant Morbidities including HIV Infection, Contribute to Infant Growth Faltering during the First 2 Years of Life
Identifieur interne : 001718 ( Pmc/Corpus ); précédent : 001717; suivant : 001719Time-independent Maternal and Infant Factors and Time-dependent Infant Morbidities including HIV Infection, Contribute to Infant Growth Faltering during the First 2 Years of Life
Auteurs : Aimee L. Webb ; Karim Manji ; Wafaie W. Fawzi ; Eduardo VillamorSource :
- Journal of Tropical Pediatrics [ 0142-6338 ] ; 2008.
Abstract
Studies investigating the predictors of growth in infants born to HIV-infected women in developing countries are limited. Using data from 886 Tanzanian HIV-infected women and their infants, we examined the impact of maternal socioeconomic and immunological status, infant characteristics at birth, and HIV, diarrhea and respiratory infections on infants’ monthly length-for-age (LAZ) and length-for-weight (WLZ)
Url:
DOI: 10.1093/tropej/fmn068
PubMed: 18723575
PubMed Central: 2734313
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Webb</name><affiliation><nlm:aff id="AFF1">Department of Anthropology, Laboratory for the Study of Constraints on Child Nutrition and Care, University of Toronto, Toronto ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Manji, Karim" sort="Manji, Karim" uniqKey="Manji K" first="Karim" last="Manji">Karim Manji</name><affiliation><nlm:aff id="AFF2">Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</nlm:aff></affiliation></author><author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W." last="Fawzi">Wafaie W. Fawzi</name><affiliation><nlm:aff id="AFF3">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="AFF4">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Villamor, Eduardo" sort="Villamor, Eduardo" uniqKey="Villamor E" first="Eduardo" last="Villamor">Eduardo Villamor</name><affiliation><nlm:aff id="AFF3">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="AFF4">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18723575</idno><idno type="pmc">2734313</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734313</idno><idno type="RBID">PMC:2734313</idno><idno type="doi">10.1093/tropej/fmn068</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001718</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001718</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Time-independent Maternal and Infant Factors and Time-dependent Infant Morbidities including HIV Infection, Contribute to Infant Growth Faltering during the First 2 Years of Life</title><author><name sortKey="Webb, Aimee L" sort="Webb, Aimee L" uniqKey="Webb A" first="Aimee L." last="Webb">Aimee L. Webb</name><affiliation><nlm:aff id="AFF1">Department of Anthropology, Laboratory for the Study of Constraints on Child Nutrition and Care, University of Toronto, Toronto ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Manji, Karim" sort="Manji, Karim" uniqKey="Manji K" first="Karim" last="Manji">Karim Manji</name><affiliation><nlm:aff id="AFF2">Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</nlm:aff></affiliation></author><author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W." last="Fawzi">Wafaie W. Fawzi</name><affiliation><nlm:aff id="AFF3">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="AFF4">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Villamor, Eduardo" sort="Villamor, Eduardo" uniqKey="Villamor E" first="Eduardo" last="Villamor">Eduardo Villamor</name><affiliation><nlm:aff id="AFF3">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="AFF4">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Tropical Pediatrics</title><idno type="ISSN">0142-6338</idno><idno type="eISSN">1465-3664</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Studies investigating the predictors of growth in infants born to HIV-infected women in developing countries are limited. Using data from 886 Tanzanian HIV-infected women and their infants, we examined the impact of maternal socioeconomic and immunological status, infant characteristics at birth, and HIV, diarrhea and respiratory infections on infants’ monthly length-for-age (LAZ) and length-for-weight (WLZ) <italic>z</italic>-scores during the first 2 years of life. We used restricted cubic splines to estimate average adjusted growth curves by categories of each predictor. LAZ decreased significantly during the first 2 years. WLZ increased from birth to 4 months but decreased significantly thereafter. Greater maternal schooling significantly reduced deterioration in LAZ and WLZ scores from birth to 24 months, while maternal CD4 cell counts <bold>≥</bold>200 mm<sup>−3</sup> at baseline were associated with reduced deterioration in LAZ scores. Infants born pre-term or with low-birth weight were significantly more stunted and wasted than their reference groups at all time points though their rate of growth faltering was slower. Infant-HIV status was strongly associated with significantly greater deterioration in LAZ and WLZ scores, beginning at about 4 months of age. Episodes of diarrhea or respiratory infections were related to significantly lower WLZ but not LAZ scores, independent of infant-HIV status. In conclusion, maternal schooling, immunological status and infant infections are important predictors of early growth in children born to HIV-positive women.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Trop Pediatr</journal-id><journal-id journal-id-type="publisher-id">tropej</journal-id><journal-id journal-id-type="hwp">tropej</journal-id><journal-title-group><journal-title>Journal of Tropical Pediatrics</journal-title></journal-title-group><issn pub-type="ppub">0142-6338</issn><issn pub-type="epub">1465-3664</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18723575</article-id><article-id pub-id-type="pmc">2734313</article-id><article-id pub-id-type="doi">10.1093/tropej/fmn068</article-id><article-id pub-id-type="publisher-id">fmn068</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Papers</subject></subj-group></article-categories><title-group><article-title>Time-independent Maternal and Infant Factors and Time-dependent Infant Morbidities including HIV Infection, Contribute to Infant Growth Faltering during the First 2 Years of Life</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Webb</surname><given-names>Aimee L.</given-names></name><xref ref-type="aff" rid="AFF1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Manji</surname><given-names>Karim</given-names></name><xref ref-type="aff" rid="AFF2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fawzi</surname><given-names>Wafaie W.</given-names></name><xref ref-type="aff" rid="AFF3"><sup>c</sup></xref><xref ref-type="aff" rid="AFF4"><sup>d</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Villamor</surname><given-names>Eduardo</given-names></name><xref ref-type="aff" rid="AFF3"><sup>c</sup></xref><xref ref-type="aff" rid="AFF4"><sup>d</sup></xref></contrib></contrib-group><aff id="AFF1"><sup>a</sup>Department of Anthropology, Laboratory for the Study of Constraints on Child Nutrition and Care, University of Toronto, Toronto ON, Canada</aff><aff id="AFF2"><sup>b</sup>Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</aff><aff id="AFF3"><sup>c</sup>Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</aff><aff id="AFF4"><sup>d</sup>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</aff><author-notes><corresp>Correspondence: E. Villamor, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA, 02115, USA. Tel.: <phone>+1 617-4321238</phone>; Fax: <fax>+1 617-4322435</fax>. E-mail <<email>evillamo@hsph.harvard.edu</email>>.</corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>22</day><month>8</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2010</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>55</volume><issue>2</issue><fpage>83</fpage><lpage>90</lpage><permissions><copyright-statement>© The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</copyright-statement><copyright-year>2008</copyright-year></permissions><abstract><p>Studies investigating the predictors of growth in infants born to HIV-infected women in developing countries are limited. Using data from 886 Tanzanian HIV-infected women and their infants, we examined the impact of maternal socioeconomic and immunological status, infant characteristics at birth, and HIV, diarrhea and respiratory infections on infants’ monthly length-for-age (LAZ) and length-for-weight (WLZ) <italic>z</italic>-scores during the first 2 years of life. We used restricted cubic splines to estimate average adjusted growth curves by categories of each predictor. LAZ decreased significantly during the first 2 years. WLZ increased from birth to 4 months but decreased significantly thereafter. Greater maternal schooling significantly reduced deterioration in LAZ and WLZ scores from birth to 24 months, while maternal CD4 cell counts <bold>≥</bold>200 mm<sup>−3</sup> at baseline were associated with reduced deterioration in LAZ scores. Infants born pre-term or with low-birth weight were significantly more stunted and wasted than their reference groups at all time points though their rate of growth faltering was slower. Infant-HIV status was strongly associated with significantly greater deterioration in LAZ and WLZ scores, beginning at about 4 months of age. Episodes of diarrhea or respiratory infections were related to significantly lower WLZ but not LAZ scores, independent of infant-HIV status. In conclusion, maternal schooling, immunological status and infant infections are important predictors of early growth in children born to HIV-positive women.</p></abstract><kwd-group><kwd>HIV</kwd><kwd>growth</kwd><kwd>infants</kwd><kwd>morbidity</kwd><kwd>Tanzania</kwd><kwd>LAZ scores</kwd><kwd>WLZ scores</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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